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BDS1 > Chronic inflammation > Flashcards

Chronic inflammation Flashcards

1
Q

What is the difference between acute and chronic inflammation?

A

Acute inflammation occurs rapidly (days) whilst chronic inflammation is persistent and can occurs over months, years and possibly forever

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2
Q

What are the 3 main classes of chronic inflammation?

A

Non-specific chronic inflammation
Specific chronic inflammation
Chronic granulomatous inflammation

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3
Q

What is non-specific chronic inflammation dominated by?

A

Tissue macrophages
T cells and B cells

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4
Q

What is an example of specific chronic inflammation?

A

Autoimmune diseases

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5
Q

What is specific chronic inflammation characterised by?

A

Excessively activated macrophages

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6
Q

What non-immunological agents are specific chronic inflammation induced by?

A

Foreign body reactions
Noxious materials (silica and asbestos)

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7
Q

What immunological agents are specific chronic inflammation induced by?

A

Infective organisms that grow in cells
Hypersensitivity reactions
Autoimmune reactions
Infection by fungi, protozoa or parasites

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8
Q

What are modified activated macrophages also known as?

A

Epithelioid Macrophages

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9
Q

What are the immunological causes of chronic granulomatous inflammation?

A

Delayed hypersensitivity or invading pathogens

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10
Q

What are the non-immunological causes of chronic granulomatous inflammation?

A

Foreign bodies in tissue

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11
Q

What’s the main aim of macrophages?

A

Phagocytose and present antigens

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12
Q

What are the two types of macrophages?

A

M1 - pro-inflammatory
M2 - anti-inflammatory

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13
Q

FORMATION OF GRANULOMA

A
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14
Q

What is an example of chronic granulomatous inflammation?

A

Orofacial Granulomatosis

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15
Q

What is ECM remodelled by?

A

Matrix Metalloproteinases (MMPs)

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16
Q

What is bone reabsorption known as?

A

Osteoclastogenesis

17
Q

What is bone formation known as?

A

Osteoblastogenesis

18
Q

How often do you get a new skeleton?

A

Every 10 years

19
Q

What do osteoclasts differentiate from?

A

Macrophages

20
Q

What is produced by osteoblasts to activate the receptor on osteoblasts?

A

Receptor activator of Nuclear Factor Kappa-B ligand (RANKL)

21
Q

What is the receptor on osteoblasts known as?

A

RANK

BDS1 (43 decks)

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