Hypersensitivity Flashcards

1
Q

What is an allergen?

A

An allergen is an antigen that causes an allergic reaction

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2
Q

What is type 1 hypersensitivity reaction mediated by?

A

IgE

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3
Q

What can type 1 hypersensitivity also be known as?

A

Immediate hypersensitivity

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4
Q

What can hypersensitivity type 1 reaction lead to ?

A

Anaphylaxis

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5
Q

What cells do type 1 allergens bind to IgE antibodies on?

A

Mast cells

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6
Q

What are haptens?

A

Any small molecule that can be recognized by a specific antibody but cannot by elicit an immune response

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7
Q

How can a hapten stimulate an immune response?

A

Must be chemically linked to a protein molecule

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8
Q

Main roles of type 1 hypersensitivity?

A

-immune cell recruitment
-neurotransmitter
-vasodilator
-endothelial constrictor

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9
Q

What is atopy?

A

The genetic tendency to develop allergic diseases to allaergens

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10
Q

What are examples of cutaneous atopy?

A

Hay fever
Eczema
Asthma

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11
Q

What are different allergy tests?

A

-Skin prick and patch tests
-Blood test
-Food challenge

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12
Q

What are examples of anti-allergy drugs?

A

Anti-histamines
Hydrocortisone
Epinephrine

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13
Q

What are immunological treatments for allergies?

A

Hypo or de sensitisation (repeat injections of allergen)
IgE to IgG production

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14
Q

How do anti-histamines work?

A

Compete with histamine for receptors

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15
Q

When is epinephrine used?

A

Anaphylactic shock

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16
Q

What is an example of type II hypersensitivity?

A

Transfusion reactions
Autoimmune hemolytic anaemia

17
Q

What is an example of type III hypersensitvity?

A

Arthus reaction
Oral erythema multiforme

18
Q

What is the key difference within type IV hypersensitivity reaction?

A

It is T cell mediated ( no antibodies)

19
Q

What is an example of a type IV hypersensitivity reaction?

A

Contact dermatitis
Oral facial granulomatous (OFG)

20
Q

What is type 2 and 3 hypersensitivity meidated by?

A

IgG or IgM