Hypersensitivity Flashcards
What is an allergen?
An allergen is an antigen that causes an allergic reaction
What is type 1 hypersensitivity reaction mediated by?
IgE
What can type 1 hypersensitivity also be known as?
Immediate hypersensitivity
What can hypersensitivity type 1 reaction lead to ?
Anaphylaxis
What cells do type 1 allergens bind to IgE antibodies on?
Mast cells
What are haptens?
Any small molecule that can be recognized by a specific antibody but cannot by elicit an immune response
How can a hapten stimulate an immune response?
Must be chemically linked to a protein molecule
Main roles of type 1 hypersensitivity?
-immune cell recruitment
-neurotransmitter
-vasodilator
-endothelial constrictor
What is atopy?
The genetic tendency to develop allergic diseases to allaergens
What are examples of cutaneous atopy?
Hay fever
Eczema
Asthma
What are different allergy tests?
-Skin prick and patch tests
-Blood test
-Food challenge
What are examples of anti-allergy drugs?
Anti-histamines
Hydrocortisone
Epinephrine
What are immunological treatments for allergies?
Hypo or de sensitisation (repeat injections of allergen)
IgE to IgG production
How do anti-histamines work?
Compete with histamine for receptors
When is epinephrine used?
Anaphylactic shock