Med-Surg: Chapter 19: Type V Hypersensitivity: Stimulated

Question 1

Type V Hypersensitivity

Answer 1

antibody-mediated cellular dysfunction

• leads to a change in cell function but does not lead to cell death as in type II
• there is an excessive stimulation of a normal cell-surface receptor by an autoantibody; results in a continuous turned-on state for the cell
  ex: Graves’ Disease (a form of hyperthyroidism)

Question 2

Pathophysiology

Answer 2

an autoantibody binds to the thyroid-stimulating hormone receptor sites on the thyroid gland

• the action of the binding results in a continual stimulation of thyroid cells to produce thyroid hormone
• the normal feedback system is no longer working to stop the overproduction of thyroid hormones

Question 3

Manifestations

Answer 3

• thyroid gland is normal

- manifestations that are exhibited are those of hyperthyroidism

Question 4

Example of Type V Hypersensitivity Reaction

Answer 4

Graves’ Disease