Med-Surg: Cancer Treatment Options Flashcards

1
Q

Tumor Reduction

A

can be done through topical procedures (cryosurgery, laser therapy, ablation) or by destruction of the main arteries that provide blood flow to the tumor (artery embolization)

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2
Q

Tumor Excision

A

can be open or endoscopic (curettage and electrodissection for skin cancer)

  • the tumor and tissue immediately surrounding it (tumor margin) are removed; Goal: all of the outermost tissue that was removed does not contain cancer cells (a negative margin)
  • surgery can be done for biopsy (diagnosis and staging), or relief (palliative)
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3
Q

Lymph Node Dissection

A

or sentinel lymph node biopsy

-done to determine if the cancer has spread or there is added risk of spread

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4
Q

Chemotherapy

A

involves administration of systemic or local cytotoxic medications that damage cells DNA or destroy rapidly dividing cells

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5
Q

Chemotherapy Route

A
  • given topical (for skin lesions), oral, parenteral, IV, intra-arterial, intraventricular (ventricles of the brain), intracavitary which includes intraperitoneal (abdominal cavity), intravesicular (into bladder), intrapleural (into pleural space), and intrathecal (into spinal cavity)
  • specialized training for administration
  • oral anticancer medications are just as toxic to the client taking the medication and the nurse handling the medication as are standard chemotherapy medications
  • oral medications should not be crushed, split, broken, or chewed
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6
Q

Chemotherapy: Catheters

A

a central catheter is usually placed for IV chemotherapy administration or blood testing

  • some medications can cause damage to the skin and muscle tissue if they leak outside a vein (vesicants)
  • a port is implanted for long-term basis
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7
Q

Chemotherapy: Nursing Actions

A
  • instruct client on proper use of vascular access devices
  • instruct family to dispense oral medications directly into a cup and not to touch pills or liquids with the hands
  • closely monitor IV infusions and provide immediate treatment or extravasation; identify the antidote for medication client is receiving
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8
Q

Chemotherapy Complications

A
  • immunosuppression/neutropenia
  • nausea, vomiting, anorexia
  • alopecia
  • hypersensitivity
  • oral mucositis
  • anemia/thrombocytopenia
  • peripheral neuropathy
  • cognitive impairment
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9
Q

Chemotherapy Complications: Immunosuppression/Neutropenia

A

due to bone marrow suppression by cytotoxic medications

  • pts with neutropenia might not develop a high fever or have purulent drainage even when infection present
  • risk of serious infection increases as the absolute neutrophil count (ANC) falls. An ANC less than 1,000/mm3 = weak immune system and need to initiate neutropenic precautions

> Nursing:

  • monitor temperature, WBC count, and ANC
  • report fever greater than 100 Degrees F to provider
  • monitor skin and mucous membranes for infection (breakdown, fissures, and abscess)
  • obtain cultures prior to initiating prescribed antimicrobial therapy

> Client Education:

  • avoid crowds while undergoing chemotherapy
  • take temperature daily. report elevated temp
  • avoid food sources that could contain bacteria (fresh fruits and vegetables, undercooked meat, fish, and eggs, pepper, and paprika)
  • avoid yard work, gardening, or changing a pet’s litter box; wear disposable gloves when working with house plants or outdoor gardening
  • discard liquid beverages that have been sitting at room temperature for longer than 1 hr
  • wash all dishes in hot, soapy water or a dishwasher
  • wash glasses and cups after each use
  • wash toothbrush daily in the dishwasher or rinse in a bleach solution
  • do not share toiletry or personal hygiene items with others
  • report manifestations of bacterial or viral infections immediately to the provider
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10
Q

Neutropenic Precautions

A
  • assign a private room; have client remain in the room unless they need to leave for a diagnostic procedure or therapy; place mask on client during transport
  • protect from sources of infection (live plants, stagnant water, contaminated equipment)
  • perform hand hygiene
  • restrict visitors who are ill
  • avoid invasive procedures that could cause a break in tissue (rectal temperatures, injections, indwelling urinary catheters) unless necessary
  • keep dedicated equipment (blood pressure machine, thermometer, stethoscope) in clients room
  • administer colony-stimulating factors (filgrastim) to facilitate WBC production
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11
Q

Filgrastim

A

facilitate WBC production

filgraSTIM

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12
Q

Chemotherapy Complications: Nausea, vomiting, anorexia

A

many medications used for chemotherapy are emetogenic (induce vomiting) or cause anorexia and an altered taste in the mouth

> Nursing Actions:

  • ensure antiemetics are given before chemotherapy and repeated based on the response and duration of CINV
  • administer antiemetic medications several days after each treatment, even when CINV appears to be controlled
  • remove vomiting cues such as odor and emesis basins
  • nonpharmacological methods to reduce nausea (visual imagery, relaxation, acupuncture, distraction)
  • calorie counts to determine intake; provide liquid nutritional supplements as needed; add protein powders to food or tube feedings
  • administer megestrol to increase appetite if prescribed
  • assess for dehydration and fluid or electrolyte imbalance
  • perform mouth care prior to serving meals to enhance appetite

> Client Education

  • some antiemetics can provide prophylactic treatment if given before meals
  • eat several small meals a day if better tolerated
  • eating low-fat dry foods (crackers, toast) and avoiding drinking liquids during meals can prevent nausea
  • select foods that are served cold and do not require cooking; cooking food can emit odors that stimulate nausea
  • encourage consumption of high-protein, high-calorie, nutrient-dense foods
  • avoid low or empty calorie foods; use meal supplements as needed
  • use plastic eating utensils, suck on hard candy, and avoid consuming red meat to prevent or reduce the sensation of metallic taste
  • create food diary to identify items that can trigger nausea
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13
Q

Chemotherapy Complications: Alopecia

A

hair loss

  • temporary
  • can vary, can occur anywhere on the body

> Nursing Actions:

  • discuss effect on self-image
  • discuss options (hats, turbans, wigs) to deal with hair loss
  • reinforce that hair should return about 1 month after chemotherapy is d/c; new hair can differ from original hair in color, texture, and thickness

> Client education

  • hair loss occurs 7 to 10 days after treatment begins
  • avoid use of damaging hair care measures (electric rollers, curling irons, hair dye, permanent waves)
  • a soft hair brush or wide-tooth comb for grooming
  • consider cutting the hair short before treatment to decrease weight on hair follicle
  • consider collaborating with hairdresser to assist with wig selection; wearing a wig before therapy begins can reduce appearance changes
  • after hair loss, protect scalp from sun exposure and use a diaper rash ointment/cream for itching
  • use head coverings to reduce body heat loss and protect skin while wearing helmets, headphones, headsets, or wigs
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14
Q

Chemotherapy Complications: Hypersensitivity

A

reactions can occur as early as 1 hr following infusion but possible after several doses

> Nursing:

  • stop medication immediately if manifestations of hypersensitivity occurs
  • assist with administration of emergency treatment

> client education

  • watch for and report indications of hypersensitivity reaction immediately
  • if hypersensitivity occurs, desensitization to the medication might be required so that the client can continue to receive the treatment most appropriate to combat the cancer
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15
Q

Chemotherapy Complications: Oral mucositis

A

inflammation in the mucous lining of the upper GI tract from the mouth to the stomach

> Nursing:

  • examine clients mouth several times a day, and inquire about presence of oral lesions
  • document the location and size of lesions; for new lesions obtain a specimen for culture and report to provider
  • avoid using glycerin-based mouthwashes or swabs; nonalcoholic, anesthetic mouthwashes recommended
  • administer topical anesthetic prior to meals
  • discourage consumption of salty, acidic, or spicy foods
  • offer oral hygiene after and before meals
  • use lubricating or moisturizing agents to counteract dry mouth

> Client Education:

  • rinse mouth with a solution of 0.9% sodium chloride, room-temperature tap water, or salt and soda water
  • gentle flossing and brushing using a soft-bristled toothbrush or foam swabs to avoid traumatizing the oral mucosa
  • rinse mouth before and after meals
  • avoid mouthwash that contains alcohol or other irritants
  • take medications to control infection (nystatin suspension, acyclovir)
  • follow recommendations regarding use of coating agents, topical analgesics, topical anesthetics, or oral parenteral analgesics
  • choose soft, bland foods and supplements that are high in calories (mashed potatoes, scrambled eggs, cooked cereal, milk shakes, ice cream, frozen yogurt, bananas, and breakfast mixes)
  • avoid spicy, salty, acidic, rough, or hard food
  • avoid drinking alcohol and the use of tobacco
  • drink at least 2 L of water per day unless there is a fluid restriction
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16
Q

Chemotherapy Complications: Anemia

A

secondary to bone marrow suppression (myelosuppression)

> Nursing:

  • monitor for fatigue, pallor, dizziness, and SOB
  • schedule activities with rest periods in between and using energy saving measures (sitting during showers and ADLs)
  • administer erythropoietic medications (darbepoetin alfa, epoetin alfa) and antianemic medications (ferrous sulfate)
  • monitor hemoglobin values to determine response to medications
17
Q

Chemotherapy Complications: Thrombocytopenia

A

secondary to bone marrow suppression (myelosuppression)

> Nursing:

  • monitor for petechiae, ecchymosis, bleeding of the gums, nosebleeds, and occult or frank blood in stools, urine, or vomitus
  • institute bleeding precautions
  • avoid IV’s and injections; when needlesticks necessary use the smallest gauge needle possible
  • apply pressure for 10 minutes after blood obtained
  • handle client gently and avoid trauma
  • administer thrombopoietic medications (oprelvekin) to stimulate platelet production
  • monitor platelet count, and be prepared to administer platelets if counts fall below 10,000/mm3
18
Q

Client Education regarding Anemia and Thromboycytopenia

A
  • understand how to manage active bleeding
  • use electric razors and soft-bristled tooth brush
  • avoid blowing nose vigorously
  • ensure dentures fit appropriately
  • avoid participation in contact sports or any activity in which injury is likely
  • avoid NSAIDs
  • wear close-toed shoes
  • remove tripping hazards in the home
  • apply cold if injury occurs
19
Q

Chemotherapy Complications: Peripheral Neuropathy

A

loss of sensory or motor function of peripheral nerves is caused by exposure to certain anticancer medications; higher doses lead to greater neuropathy

> Nursing:

  • monitor for loss of sensation in hands and feet, orthostatic hypotension, loss of taste, and constipation
  • monitor for orthostatic hypotension
  • monitor for early manifestations including numbness, tingling, and redness
  • prevent injury, falls
  • risk of erectile dysfunction

> Client Education:

  • protect skin because loss of sensation makes the client unaware of heat, cold, or pressure
  • inspect feet daily for any open areas
20
Q

Chemotherapy Complications: Cognitive impairment

A

cognitive changes occurring during and after chemotherapy treatment, including difficulty learning, decreased concentration, and memory loss

> Nursing Actions:
-support by providing cognitive training resources

> Client Education

  • avoid behaviors that could contribute to cognitive dysfunction (excessive intake of alcohol, recreational drug use, and activities high-risk for head injury)
  • engage in strategies to improve memory and concentration, such as repeating challenging tasks
21
Q

Radiation Therapy

A

involves high-energy radiation to target tissues and destroy cells; some cells are not destroyed but might become weakened and unable to divide, while others might be able to recover from the radiation damage

22
Q

Radiation Information

A
  • usually given on a daily basis for a set period of time
  • can be given preoperatively to decrease size of tumor
  • adverse effects on tissues within the radiation path include skin changes, hair loss, and debilitating fatigue
  • can be administered internally (brachytherapy) with an implant or externally (teletherapy) with a radiation beam
  • external beam radiation therapy does not cause the client to become radioactive
  • internal radiation causes body fluids to be contaminated with radiation, and body wastes should be disposed of appropriately
  • Cytoprotectants, such as amifostine, are sometimes used to protect against harmful affects of radiation, such as dryness of the mouth
  • radiation exposure to health care personnel and visitors is reduced by limiting indirect contact time, maintaining indicated distances from sources of radiation, and preventing direct contact with the source
23
Q

Internal Radiation Therapy

A

brachytherapy

  • placed close to the target tissue
  • done via body orifice (vagina) or body cavity (abdomen) or delivered via IV such as with radionuclide iodine, which is absorbed by thyroid
  • brachytherapy provides radiation to the tumor and a limited amount to surrounding normal tissues
  • the client’s excretions are radioactive until the isotope has been completely eliminated from the body; ensure no one touches the clients excretions

> Nursing Actions:

  • place client in a private room; keep door closed as much as possible
  • place sign on door warning of the radiation source
  • wear a dosimeter film badge that records personal amount of radiation exposure
  • limit visitors to 30-minute visits, and maintain a distance of 6-feet from source
  • pregnant, trying to conceive, or under age of 16 years should not enter client’s room
  • wear a lead apron while providing care
  • keep a lead container in the client’s room if the delivery method could allow spontaneous loss of radioactive material; tongs are available for placing radioactive material into this container
  • follow proper protocol for proper removal of dressings and bed linens from room; all linens and dressings are kept in the room until radiation source is removed, to ensure it is not lost in trash or laundry

> Client Education

  • remain in position prescribed by provider to prevent dislodgment of radiation implant
  • call nurse with assistance for elimination
  • follow radiation precautions
24
Q

External Beam Radiation Therapy (EBRT)

A

or teletherapy is delivered in small doses over the course of several weeks and aimed at the body from an external source
-not radioactive and not hazardous to others

> Nursing Actions:
-the skin over the targeted area is marked with “tattoos” that guide the positioning of the external radiation source
-provide a well-balanced diet that does not contain red meat; radiation can cause dysgeusia (altered taste), making foods such as red meat unpalatable
-help client manage fatigue by scheduling activities with rest periods in between and using energy-saving measures (sitting during showers and ADLs)
-monitor for radiation injury to skin and mucous membranes and implement a skin care regimen
Skin: blanching, erythema, desquamation, sloughing, hemorrhage
Mouth: mucositis, xerostomia (dry mouth)
Neck: difficulty swallowing
Abdomen: gastroenteritis
-monitor CBC (possible decreased platelets and WBCs)

> Client education:

  • if mucositis occurs: avoid spicy, salty, acidic foods; try eating foods that are cold rather than hot
  • gently wash the skin over the irradiated area with mild soap and water; patted drying motions; use hand to clean skin rather than cloth
  • do not remove or wash off radiation tattoos (markings) to guide therapy
  • do not apply powders, ointments, lotions, deodorants, or perfumes to the irradiated skin
  • wear soft clothing; avoid tight or constricting clothes
  • do not expose irradiated skin to sun or heat source
  • inspect skin for evidence of damage and report
25
Q

Hormone Therapy

A

is effective against tumors that are supported or suppressed by hormones, such as in breast or prostate cancer

  • by giving a similar hormone, uptake of the support hormone is blocked, or production reduced
  • luteinizing hormone-releasing hormone (LH-RH) agonists like leuprolide and goserelin are effective against tumors that require a particular hormone for support
26
Q

Hormone Therapy: LH-RH agonists

A

> Nursing:
-monitor cardiac status and blood pressure and pulmonary edema

> Client education:

  • if male, understand effect on sexual functions (decreased libido, erectile dysfunction) and feminizing effects of hormone therapy (gynecomastia, hot flashes, bone loss)
  • increase intake of calcium and vitamin D
  • if female, understand masculinizing effects (chest and facial hair growth, amenorrhea, decreased breast tissue)
27
Q

Hormone Therapy: Estrogen Antagonists

A

Tamoxifen
>Nursing Actions:
-monitor CBC, clotting times, lipid profiles, calcium and cholesterol levels, and liver function for medication-related changes
-monitor neurologic and cardiovascular functioning changes

> Education:

  • understands the adverse effects, which include nausea, vomiting, hot flashes, weight gain, vaginal bleeding, and increased risk of thrombosis
  • understand need for yearly gynecological exams and need to take calcium and vitamin D supplement
28
Q

Immunotherapy

A

(biotherapy)
alters a client’s biological response to cancerous tumor cells
-antibodies, cytokines, and other immune substances normally produced by the immune system are administered to increase the body’s defenses against cancer
-includes biological response modifiers (BRM), monoclonal antibody targeted therapy, and cancer vaccines

> Interleukins: help coordinate the inflammatory and immune responses of the body, particularly the lymphocytes

> Interferons: when stimulated, can exert an antitumor effect by activating a variety of responses

> Monoclonal antibodies: targeted therapy that binds to cancer cell proteins to inhibit cell division, make the cells more sensitive to treatment, and improve the body’s ability to attack the cancer cells

> Cancer Vaccines: can prevent infections that predispose a client to cancer (HPV), stop cancer from developing further, or kill cancer cells. Sipuleucel-T is only FDA approved therapeutic cancer vaccine

29
Q

Nursing Actions and Client Education for Immunotherapy

A

> Interleukins: monitor for generalized edema, which impairs organ function

> Interferons: monitor for peripheral neuropathy that can affect vision, hearing, balance, and gait
-take precautions for orthostatic hypotension

> Monitor client receiving BRM therapy for manifestations of inflammation (rigors, chills, malaise, fever, nausea, diarrhea, and anorexia)

  • observe for indication of neurological effects of BRM (agitation, hallucinations, sleep disorders, nightmares, mood swings, somnolence)
  • check clients skin for peeling, pruritis, or dryness; protect skin from sunlight, and use mild cleansers and moisturizers

> Client Education:

  • report influenza-like manifestations or changes consistent with neuropathy
  • use perfume-free moisturizer
  • avoid sun exposure and swimming if skin manifestations develop