Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Year 1 Cell Biology > Lymphatic tissue and organs > Flashcards

Lymphatic tissue and organs Flashcards

1
Q

What are the primary lymphatic tissues?

A
  1. Bone marrow2. Thymus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What occurs at primary lymphatic tissues?

A

Development and maturation of lymphocytes into immunocompetent cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the secondary lymphatic tissues?

A
  1. Lymph nodes2. Mucosa-associated lymphatic tissue (MALT)3. Spleen
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What occurs at secondary lymphatic tissues?

A

Formation of immunological defense against antigens or pathogens; confrontation with antigens or pathogens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MALT consists of what other lymphatic regions?

A
  1. GALT (gut-associated lymphatic tissue)2. BALT (bronchus-associated lymphatic tissue)3. GU tract4. Tonsils
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

In which layer of the epithelium is GALT located?

A

Lamina propria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are characteristics of diffuse lymphatic tissue (MALT)?

A
  1. Not sharply delineated2. Part of some other organ, often sprinkled through lamina propria3. Reticular fibers provide framework for cell suspension
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which cells are found in diffuse lypmhatic tissue?

A

Lymphocytes, monocytes, macrophages, plasma cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are characteristics of lymphatic nodules (follicles)?

A
  1. Non-encapsulated, spherical, dense aggregations of lymphocytes with SOME organization2. May be primary or secondary3. May be solitary or aggregate structures
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are characteristics of primary lymphatic nodules?

A

Appear homogeneous throughout, have mostly small lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are characteristics of secondary lymphatic nodules?

A

Have two zones - corona (mantle) zone and germinal center

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the mantle zone?

A

The outer, dark-staining zone containing mature (small) lymphocytes in a secondary lymphatic nodule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the germinal center?

A

The inner, light-staining zone containing immature (medium and large) lymphocytes in a secondary lymphatic nodule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What happens to a secondary lymphatic nodule when an antigen is encountered?

A

Germinal center starts to swell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Are solitary lymphatic nodules temporary or permanent?

A

Temporary - may appear and reappear at a particular site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Are lymphatic aggregates temporary or permanent?

A

Permanent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are examples of lymphatic aggregates?

A
  1. Peyer’s patches in the ileum2. Lymphatic tissue in the appendix (lamina propria and submucosa)3. BALT in respiratory tract4. Lymphatic nodules in tonsils, lymph nodes, spleen
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

The tonsils have what kind of lymphatic tissue organization?

A

Aggregations of lymphatic nodules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What type of lymphocyte predominates in the tonsils?

A

B lymphocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What kind of epithelium covers the pharyngeal tonsils?

A

Pseudostratified columnar epithelium with cilia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Do the pharyngeal tonsils have crypts?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What do the pharyngeal tonsils have instead of crypts?

A

Pleats

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What kind of epithelium covers the palatine tonsils?

A

Stratified squamous nonkeratinized infiltrated by B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Do the palatine tonsils have crypts?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Where are B cells produced in the palatine tonsils?
Germinal centers found in the nodules
26
What kind of epithelium covers the lingual tonsils?
Stratified squamous nonkeratinized
27
Do the lingual tonsils have crypts?
Yes
28
What are lymph node trabeculae?
CT septa that extend from capsule into lymph node carrying vessels and nerves
29
What are characteristics of subcapsular sinuses?
Deep to CT capsule, drain into trabecular sinuses
30
What are characteristics of trabecular sinuses?
1. Separate nodules from trabeculae2. Drain into medullary sinuses3. Lined by endothelial cells - allow lymphatic cells to enter or exit4. Contain reticular cells
31
Which lymph sinuses are lined by macrophages?
All sinuses
32
What are the cells of the reticular meshwork?
1. Reticular cells2. Dendritic cells3. Macrophages4. Follicular dendritic cells
33
What is the reticular tissue?
Consists of reticular cells and reticular fibers which form a fine 3D meshwork that suspends the cells and sinuses and supports lymph node contents
34
What is the function of the reticular cells?
Synthesize and secrete type III collagen. Cytoplasmic processes wrap around reticular fibers to isolate them from lymphatic tissue parenchyma
35
What is the function of dendritic cells in a lymph node?
Ag presentation
36
What is the function of macrophages in lymph nodes?
Ag presentation, phagocytic
37
What is the function of follicular dendritic cells in lymph nodes?
Bind Ag-Ab complexes
38
What comprises the parenchyma of a lymph node?
1. Cortex2. Paracortex3. Medulla
39
What type of lymphatic tissue organization is found in the cortex of the lymph node?
Nodules
40
What type of lymphocyte is found in the cortex of the lymph node?
B cell
41
What type of cells are found in the germinal center of the lymph node nodules?
Dendritic reticular cells
42
What type of lymphocyte is found in the paracortex of a lymph node?
T cell
43
Are nodules primary or secondary?
Secondary
44
Are nodules permanent or temporary?
Permanent
45
What part of the lymph node is thymus-dependent?
Paracortex
46
What are high endothelial venules?
1. Located in the paracortex2. Lined with simple cuboidal to columnar epithelium3. B and T cells escape from bloodstream via HEVs to enter paracortex (B cells keep going to cortex)
47
What percentage of lymphocytes enter the lymph node via the HEVs of the paracortex?
90%
48
What are medullary cords?
Irregularly shaped clumps of cells containing B, T, plasma, and dendritic cells and macrophages
49
What is the role of the thymus?
Site where T cells mature
50
In what part of the thymus do T cells mature?
Cortex
51
What type of cells form the framework of the thymus?
Epithelioreticular cells
52
What are the functions of Type 1 epithelioreticular cells?
1. Form seal around cortex to separate it from CT capsule and trabeculae2. Form sleeve around tunica adventitia of vessels3. Form tight junctions to seal thymic cortex from rest of the body
53
What is the function of Type 2 epithelioreticular cells?
1. Form meshwork in midcortex2. Held together by desmosomes3. "Teachers" of thymic cell education
54
What is the function of Type 3 epithelioreticular cells?
1. Protein synthesis2. Form tight junctions; seal between cortex and medulla
55
What is the function of Type 4 epithelioreticular cells?
Barrier at corticomedullary junction
56
What is the function of Type 5 epithelioreticular cells?
Meshwork / framework of medulla
57
What is the function of Type 6 epithelioreticular cells?
Form Hassall's corpuscles
58
What are Hassall's corpuscles?
Made of Type 6 epithelioreticular cells - they are concentric, eosinophilic whorls that are unique to thymic medulla. They exhibit keratinization
59
Where do mature T cells go once mature?
Enter bloodstream from medulla via postcapillary venules to take up residence in paracortex of lymph nodes and PALS of spleen
60
What makes up the blood-thymus barrier (inside-out)?
1. Endothelium2. Basal lamina3. Macrophages4. Type 1 epithelioreticular cells
61
What is DiGeorge's syndrome?
Individuals cannot produce T cells, may die from infection or tetany
62
Does the thymus have afferent lymphatic vessels?
No
63
What makes up the white pulp of the spleen?
1. Periarterial lymphatic sheath2. Splenic nodules
64
What are the characteristics of the periarterial lymphatic sheath?
1. Thymus-dependent zone of the splenic pulp2. Contains T cells3. Central artery is centrally located within PALS
65
What are the characteristics of the splenic nodules?
1. Lymphatic nodules2. Contain B cells3. May contain germinal center around central artery4. Central artery is eccentrically located in nodule
66
What makes up the red pulp of the spleen?
1. Splenic cords2. Splenic sinuses
67
What are the Cords of Billroth?
1. Irregular and branching cords of splenic tissue2. Contain loose network of reticular cells and fibers3. Spaces between fibers are filled with blood to be filtered4. Filter blood5. Contain macrophages, plasma cells, dendritic cells
68
What are the splenic sinuses?
1. Lined by endothelial cells with wide intercellular spaces to allow blood cells to pass in and out of sinuses2. Drain into pulp veins which in turn drain into trabecular veins

Year 1 Cell Biology (40 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions