Lecture 5 Flashcards

1
Q

What secretes cholecystokinin and in response to what

A

Acinar cells in the duodenum
In response to fatty foods and aa

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2
Q

What is a major stimulus for gallbladder contraction

A

CCK

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3
Q

CCK is a major stimulus for what

A

Gall bladder contraction

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4
Q

What 3 things does CCK do

A

Stimulates gallbladder contraction
Stimulates secretion of pancreatic juice
Relaxes hepatopancreatic sphincter

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5
Q

Bile salts are recycled through what

A

Enterohepatic circulation

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6
Q

Most bile salts are reabsorbed by what section of the GI tract

A

Ileum

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7
Q

Reabsorbed bile salts travel via what vein back to the liver

A

Hepatic portal vein

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8
Q

What is the most important stimulus for bile secretion

A

Bile salts in portal circulation

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9
Q

What triggers the release of CCK

A

Protein and fats in chyme entering the duodenum

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10
Q

during cephalic and gastric phases _____ nerve causes weak gallbladder contractions

A

Vagal nerve

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11
Q

When the gallbladder is removed, how does the body compensate?

A

It enlarges the bile duct to allow more bile to be stored

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12
Q

What is obstructive jaundice

A

liver cannot eliminate the bile, as gallstones block the pancreatic duct

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13
Q

What are acini

A

groups of secretory acinar cells clustered around ducts

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14
Q

What do acini mediate

A

Exocrine function of the pancreas

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15
Q

What does an acinar DUCT cell secrete

A

bicarbonate and water

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16
Q

Is pancreatic juice alkaine or acidic

A

Alkaline

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17
Q

How much pancreatic juice do we produce a day

A

1200-1500ml

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18
Q

What two things does the alkalinity of pancreatic juice allow it to do

A

Neutralize acidic chyme
Create optimal pH for intestinal and pancreatic enzymes

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19
Q

Why are proteolytic enzymes released in “inactive precursor form”

A

to prevent unwanted protein degredation;
make sure they activate in the proper place

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20
Q

What do amylase, lipases and nucleases typically require to function optimally

A

Bile or ions

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21
Q

What is the alkaline tide

A

Bicarbonate production in the stomach

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22
Q

What is released into the bloodstream from the pancreas that neutralizes the bicarb secreted into the blood from the stomach

A

H+ ions

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23
Q

What are the two main intestinal hormones

A

Secretin and CCK

24
Q

What controls the vagal stimulation of secretory activity in the pancreas

A

Parasympathetic nervous system

25
Q

What do duodenal enteroendocrine cells secrete in the pancreas

A

CCK and Secretin

26
Q

What is the full name of CCK

A

Cholecystokinin

27
Q

What triggers the release of secretin

A

Acidic chyme

28
Q

How does the small intestine absorb

A

Through absorptive cells through apical brush border

29
Q

How much intestinal juice is secreted a day

A

1-2 L

30
Q

what is a major stimulus for secretion of intestinal juice

A

Distension or irritation of intestinal mucosa

31
Q

Are the contents of the stomach hypo or hyper tonic?

A

Hypertonic

32
Q

What is segmentation

A

The way the SI churns, squeezing the lumen in different spots to compartmentalize

33
Q

What is segmentation initiated by

A

Intrinsic pacemaker cells

34
Q

Whats the frequency of segmentation in the duodenum

A

12-14/ min

35
Q

Whats the frequency of segmentation in the ileum

A

8-9/min

36
Q

How long is the MMC

A

90 mins

37
Q

What is the MMC

A

Migrating mobility complex
Repeated peristaltic action

38
Q

Chemical reaction for digestion of complex molecules involves _____

A

Hydrolysis

39
Q

What is a monomer

A

Monosaccharides

40
Q

Where are monosaccharides absorbed

A

Directly in the SI

41
Q

What are three major dietary monosaccharides

A

Glucose
Fructose
Galactose

42
Q

Glucose, fructose and galactose are ____ because they have the same composition

A

Isomers

43
Q

Sucrose is composed of

A

Glucose and Fructose

44
Q

Lactose is composed of

A

Galactose and glucose

45
Q

Maltose is composed of

A

Two glucose

46
Q

Glycogen and starch are:

A

Polysaccharides

47
Q

What is the common storage form for carbs in muscle and liver

A

Glycogen

48
Q

Why is glycogen a good storage form?

A

We have enzymes that will break it down very easily

49
Q

What is cellulose

A

plant polysaccharide

50
Q

Cellulose cannot be digested, but why is it important

A

It provides fiber

51
Q

Can cellulose be digested?

A

Nope

52
Q

What starts the digestion of carbohydrates

A

Salivary amylase

53
Q

What is carbs reduced to in the mouth

A

Oligosaccharides

54
Q

What is an oligosaccharides

A

3-8 monomers

55
Q

What digests salivary amylase

A

Pepsin

56
Q

What reduces most starch to maltose and where

A

Pancreatic amylase and in the SI

57
Q

What completes carb digestion to monosaccharides

A

Intestinal brush border enzymes