Lecture 26: Yersinia, Tularemia, Glanders and Pseudoglanders Flashcards

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1
Q

Yersinia pestis is the causative agent of ___

A

Plague

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2
Q

Yersinia pestis is a gram ___ bacilli

A

Negative

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3
Q

Yersinia pestis is a __zoonotic agent

A

Notifiable

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4
Q

What is distribution for Yersinia pestis

A

Worldwide, endemic in southwestern U.S

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5
Q

What domestic species is Yersinia pestis most commonly seen in

A

Cats

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6
Q

What is the main reservoir for Yersinia pestis

A

Rodents

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7
Q

How is Yersinia pestis transmitted

A

Flea bites, contact with infected carcasses

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8
Q

What are the signs for bubonic form of Yersinia pestis

A

Fever, lethargy, enlarged LN

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9
Q

What are the signs for pneumonic form of Yersinia pestis

A

Respiratory signs +/- septicemia

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10
Q

What are the signs for septicemic form of Yersinia pestis

A

No lymphadenopathy, fever, lethargy

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11
Q

How do you dx Yersinia pestis

A
  1. PCR
  2. FA test on culture
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12
Q

What is tx and prevention for Yersinia pestis

A
  1. Tetracyclines (doxycycline), Aminoglycosides
  2. Flea prevention
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13
Q

Francisella tularensis is a gram __facultative __bacillus

A

Negative, intracellular

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14
Q

Francisella tularensis readily grows on what agar

A

Chocolate agar

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15
Q

Francisella tularensis is a ___zoonotic agent

A

Notifiable

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16
Q

Where is Francisella tularensis found

A
  1. Limited to northern hemisphere
  2. Mississippi/ Missouri River valley
  3. Mountain west
  4. E/W coast
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17
Q

What are the two bio types for Francisella tularensis

A
  1. Biotype A- most virulent
  2. Biotype B- less virulent
18
Q

Who is Biotype A Francisella tularensis found in

A

Rabbits and rodents

19
Q

Who is Biotype B Francisella tularensis found in

A

Aquatic animals

20
Q

How is Francisella tularensis transmitted

A

1.aerosol- moving over dead rodents
2. Direct contact
3. Ingestion
4. Ticks

21
Q

What are the signs of Francisella tularensis in sheep and other mammals

A
  1. Signs of septicemia- fever, lethargy
  2. Cough
  3. White foci if necrosis in liver and spleen
  4. Hepatic, splenic, and LN enlargement
22
Q

Spleen from cat who liked to eat rabbits what is likely cause of these lesions

A

Francisella tularensis

23
Q

How do you dx Francisella tularensis

A
  1. Exposure to wild rabbits/ rodents/ ticks
  2. Culture
  3. PCR
24
Q

If you are sending suspected Francisella tularensis samples to lab for culture what must you do

A

Notify lab because done in BSL-3

25
Q

What is tx and prevention for Francisella tularensis

A
  1. Tetracylines
  2. Control tick and flies
26
Q

Burkholderia is a __zoonotic agent

A

Notifiable

27
Q

Who does B. Mallei typically infect

A

Horses

28
Q

Where is B. Mallei endemic

A

Hot, humid areas

29
Q

How is B. Mallei transmitted

A

Contact, inhalation, ingestion

30
Q

Lesion on horse who lives in a hot humid area. What is likely cause

A

B. Mallei

31
Q

What are the acute clinical manifestations of B. Mallei

A
  1. Pulmonary TB like lesions with caseous/ calcified centers
  2. Star shaped scars in nose
32
Q

What are the clinical manifestations for chronic B. Mallei

A
  1. Oronasal secretions
  2. Ulcerative lymphangitis
33
Q

How do you dx B. Mallei

A
  1. Culture of fresh lesions
  2. PCR
34
Q

What is tx for B. Mallei in endemic areas

A
  1. Tetracylines
    Not curative
35
Q

What is tx for B. Mallei in non-endemic areas

A

Depopulation/ euthanasia
Because treatment isn’t curative

36
Q

Where is B. Pseudomallei distributed

A

Equatorial distribution

37
Q

B. Pseudomallei is readily recovered from __ and __

A

Soil and surface water

38
Q

How is B. Pseudomallei transmitted

A

Contained soil or water

39
Q

What are the clinical manifestations of B. Pseudomallaei in horses

A

Edema
Lymphangitis

40
Q

How can you tell the difference between B. Pseudomallei and B. Mallei when dx

A

B. Pseudomallei won’t have calcified lesions

41
Q

How do you dx B. Pseudomallei

A

PCR and culture

42
Q

What is tx for B. Pseudomallei

A

Often unsuccessful so euthanasia preferred