Lecture 22: THE SMALL INTESTINE Flashcards

1
Q

What are the regions of the small intestine (in order)?

A

Duodenum, jejunum and ileum

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2
Q

What is the largest region of the small intestine?

A

Ileum

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3
Q

What is the total length of the small intestine?

A

About 6m

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4
Q

Where is the initial segment of the small intestine?

A

Retroperitoneal

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5
Q

What is the small intestine held in place by?

A

Mesentery

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6
Q

What does the mesentery allow?

A

Movement, but prevents the small intestine from getting tangled

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7
Q

What does the mesentery contain?

A

Arteries, veins, nerves and lymphatics

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8
Q

What is delivered to the small intestine?

A

Chyme which is acidic

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9
Q

What is needed because of chyme being acidic?

A

Protect the epithelium and neutralise pH

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10
Q

How is the epithelium protected?

A

By mucous secreting cells and glands in the submucosa (specifically in the duodenum)

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11
Q

How is pH neutralised?

A

By bicarbonate (HCO3-) from the pancreas

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12
Q

What are plicae circulares?

A

Permanent folds of the small intestined

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13
Q

What is the structure of plicae circulares?

A

Core of submucosa with overlying mucosa

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14
Q

Where are villi found?

A

On the surface of the plicae circulares

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15
Q

What does the muscularis mucosae allow?

A

Villi to wiggle back and forth

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16
Q

What are villi?

A

Folds of the mucosa

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17
Q

What is the core of each villus?

A

FCT (lamina propria)

18
Q

What do villi contain?

19
Q

What vessels do villi contain?

A

Lymph lacteal and capillary network

20
Q

What is drained into the lymph lacteal?

A

Products of fat digestion

21
Q

What is drained into the capillary network?

A

Products of protein and carbohydrate digestion

22
Q

What enters the mesenteric veins?

A

Nutrient rich, deoxygenated blood absorbed in the small intestine

23
Q

What do mesenteric veins drain into?

A

Hepatic (liver) portal vein

24
Q

What do lymph lacteals drain into?

A

The cisterna chyli, thoracic duct and then left subclavian vein

25
What is the epithelium of the small intestine?
Simple columnar
26
What is on the apical surface of the small intestine cells?
Microvilli to increase the surface area further
27
What do microvilli form?
A brush border
28
What is glycocalyx?
A network of glycoproteins and branched filaments
29
What does the glycocalyx do?
Tether enzymes
30
What does contact digestion involve?
Enzymes attached to the brush border
31
What is the plasma membrane?
A barrier which is selectively permeable (lipid soluble things can travel through it)
32
What does the plasma membrane have?
Proteins (channels and transporters)
33
How are tight junctions described?
Very tight
34
What junctions are between small intestine epithelial cells?
Tight junctions
35
What may diffuse through tight junctions?
Small molecules (down a concentration gradient)
36
What are the cells of the small intestine epithelium?
Enterocytes, goblet, stem, paneth and endocrine
37
What are enterocytes?
Absorptive cells which have a microvilli brush border
38
What do goblet cells do?
Secrete mucous for protection
39
What do stem cells do?
Make all cell types
40
What do paneth cells secrete?
Granules and antibacterial enzymes
41
What do endocrine cells do?
Secrete hormones
42
What is found in an intestinal crypt?
Paneth cells at the base, stem cells above and epithelial cells further above