LEC6 - MAGNESIUM Flashcards
is the fourth most abundant cation in
the body and second most abundant intracellular ion second to potassium
MAGNESIUM
It has an important role in membrane stabilization, nerve
conduction, and ion transport and calcium channel activity
MAGNESIUM
____ loop is the major renal regulatory site of magnesium
Henle’s loop
in loop of henly, where_____ of filtered Mg2+ is reabsorbed in the ASCENDING limb.
50% to 60%
In addition, ____ is reabsorbed in the distal convoluted
tubule (DCT)
2% to 5%
Renal threshold for Mg2+ is approximately ____
mmol/L (1.46–2.07 mg/dL)
0.60–0.85
____% of Mg2+ in the body is found in bone
53%
46% % of magnesium are found in
,muscle and soft tissues
how many percent are in serum
1%
less than 1% is present in serum and RBCs
▪ Of the Mg2+ present in serum, about 1/3 is
bound to ___
protein, primarily albumin.
of the 2/3 of the 1%, 61% are free or ionized and the 5% are complexed with other ions such as PO4 and citrate
correwt?
yes
magnesium is a co factor of what component in PCR
cofactor of Taq DNA polymerase
effect of magnesium in potassium levels
loss of Mg leads to decreased Intracellular K levels
bestie yan sila eh, pareho silang nasa loob. So kapag wala o kulang si Mg sa loob, ganun din gagawin ni K, aalis din siya sa loob
it is an enzyme activator and important in maintaning the structure of nucleic acids and ribosomes, as well as the synthesis of organic compounds
Mg
facial/eye twitching means
low magnesium
Parathyroid hormone (PTH) _______ the renal reabsorption of Mg2+ and enhances the absorption of Mg2+
in the intestine.
increases
releationship of calcium and magnesium when it comes to PTH
directly as they are both absorbed/reabsorbed in accordance to PTH
maraming friend si Mg.
Bukod kay K intracellulary, si calcium din when it comes to reabsorption
effect of aldosterone and thyroxine to Magnesium
kung si calcium, K, at PTH friend ni Mg.
kaaway naman niya si ALDOSTERONE and THYROXINE
aldosterone promotes renal excretion of Mg
opposite effect of PTH in the
kidney, increasing the renal excretion of Mg2+
Aldosterone and thyroxine
The overall regulation of body Mg2+ is controlled largely by what organ
kidney
_____ is reabsorbed by the proximal
convoluted tubule (PCT)
25% to 30%
Normally, only about _____% of filtered Mg2+ is excreted in the
urine per day
6%
It is a condition with high level of serum magnesium.
HYPERMAGNASEMIA
is HYPERMAGNASEMIA rare ?
yes
if it’s rare, how do we usually get HYPERMAGNASEMIA
iatrogenic due to medication
Increase in magnesium ____ the activity of tissues and organs
decreases
Dysarthria means
problem with the motor speech
Patient is prone to bleeding
hyper or hypo???
hypermagnesemia
Clinical manifestations include hypotension, bradycardia,
respiratory depression, depressed mental status and
electrocardiographic (ECG) abnormalities
hypermagnasemia - kung mapapansin mo lahat lower kasi nga high magnesium decrease organ and tieeur activities
Use of drugs with ______ given to patients with
eclampsia and cardiac arrhythmia will also have increased
magnesium activity
magnesium sulfate
It is a condition with low serum magnesium level
HYPOMAGNASEMIA
The most common causes of hypomagnesemia are:
Loss of magnesium in the GI tract
Diabetes mellitus
alcohol
stress
___is most frequently observed in
hospitalized individuals in intensive care units (ICUs) or
those receiving diuretic therapy or digitalis therapy
Hypomagnesemia
There’s a missing molecule or due to
prematurity making the reabsorption not efficient. Primary
congenital
NEONATAL
a diuretics that causes hypomagnasemia due to prolonged used
thiazides
a diuretics that causes hypomagnasemia due to fast effect
furocimides
antibiotics causing hypomagnasemia
gentamicin
cyclosporin
digoxin
why gentamicin
cyclosporin
digoxin
induces hypomagnasemia?
promotes excretion of Mg
EXCESS LACTATION causes
hypomagnasemia because baby will get the Mg
ref method of Mg
AAS
the frequent method used today for MG
photometric method analyzers
colorimetric method analyzers uses dyes, what are those
Calmagite dye
Formazan dye ???
Magon
titan yellow
methylthymol blue
most frequently sued dye in photometric assay for MG
titan yellow
ion selective electrode measures
intracellular magnesium
reference method for Mg
AAS
