Lec 3: Urinary System Histology II Flashcards
characteristic histological structures of S1, S2, S3
3 things
microvillus brush border (MBB)
lots of mitochondria & lysosomes
cuboidal cells
PCT
proximal convoluted tubule
65% of filtrate reabsorption
S1
taller
tall MBB
more MT than S2
S3
less active transport
fewer MT
thick MBB
(descending thick)
proximal tubules are sensitive to?
ischemia
debris within tubules
mercury is specifically toxic to ?
S2
chemotherapeutic cis-platinum is specifically toxic to ?
S3
loop of henle
15% of filtrate reabsorption
LOHs enter the medulla to varying depths because of ?
nephron heterogeneity
superficial, midcortical, & juxtamedullary-15%-nephrons
outer medulla
2 stripes
thick descending, thick ascending, collecting ducts
inner medulla
THIN SEGMENTS ONLY
(ascending & descending), collecting ducts
descending thick
S3 cells cuboidal straight intercellular borders fewer MT than S2 thick MBB
thin LOH
simple squamous
ascending thick
transitions back to cuboidal w/NO MBB
lots of MT
descending limb
permeable to water for the purpose of concentrating filtrate
ascending limb
permeable to salts via active & passive transport for the purpose of diluting filtrate
distal tubule
10% of filtrate reabsorption
cuboidal cells
NO MBB
less sensitive to ischemia
collecting ducts
9% of filtrate reabsorption
found from cortex in medullary rays down to papillary region of medulla
principal cells
straight intercellular borders
few organelles
stain poorly
intercalated cells
fuzzy luminal border
many organelles
stain more darkly
usually found in cortex
as the collecting duct approaches the papillary ducts
cells become more columnar
medullary rays
found in cortex
contain LOHs for superficial nephrons
thick descending & ascending LOH, collecting ducts
NO THIN LOH SEGMENTS
things found in the cortex of the kidney (4 things)
PCT/DCT
renal corpuscle
macula densa
medullary rays (thick LOH & CDs, NO THIN SEGMENTS)
transitional epithelium is only found in?
urinary passages
dome-shaped, often binucleated cells
