Language of Medicine - Chapter 13 Flashcards
Blood System
what does blood contain?
proteins, wbc, + antibodies to fight infection + platelets (thrombocytes) + other proteins to help the blood clot
what is blood composed of?
- cells = 45% of blood volume
- formed elements
- plasma = clear-straw cooled liquid (55% of blood volume)
define erythrocytes
red blood cells (rbc) - carry oxygen
- rbc matures from erythrocyte to erythroblast
- shape: depressed or hollow surface on each side of the cell
- contain: hemoglobin, heme, globin
- originate in bone marrow
- live for ~120 days
define leukocytes
white blood cells (wbc) - fight infection
- 5 types: 3 polymorphonuclear granulocytes (basophils, neutrophils, eosinophils) + 2 mononuclear leukocytes (lymphocytes + monocytes)
define platelets / thrombocytes
clotting factors
where do cells originate from?
marrow in the cavity of bones
define hematopoietic stem cells
rbc + wbc arise from these cells
define differentiated
cells change from size (large to small)
define hemoglobin
protein in rbc which is composed of heme (iron-containing pigment) + globin (protein)
- enables erythrocyte to carry oxygen
define erythropoietin
hormone that is secreted by the kidney + stimulates the production
define macrophages
destroy worn out erythrocytes
- located in spleen, liver, and bone marrow
- break down erythrocytes and hemoglobin and heme + globin
define granulocytes / polymorphonuclear leukocytes (PMNs)
most numerous (60%)
- contain lots of granules in cytoplasm
define eosinophils
- stained red
- increase in allergic responses + engulf substances that trigger allergies
define basophils
- stained a dark blue
- contain heparin (anti clotting substance) + histamine (chemical released in allergic responses)
define neutrophils
- stain a pale color
- phagocytes (phag/o = eat/swallow) that accumulate at sites of infection, where they ingest + destroy bacteria
define colony stimulating factors (CSF)
proteins that promote the growth of granulocytes in bone marrow
describe G-CSF and GM-CSF
G-CSF = granulocyte CSF
GM-CSF = granulocyte macrophage CSF
both are given to cancer patients to restore granulocyte production
define erythropoietin
produced by recombinant DNA
- stimulates rbc production (erythropoiesis)
- typically made in the kidney
define mononuclear leukocytes
- do not have large numbers of granules in their cytoplasm
define lymphocytes
- made in bone marrow + lymph nodes + circulate both in the bloodstream + in parallel circulating system + lymphatic system
- play an important role in immune response that protects the body against infection - they can directly attach foreign matter + make antibodies that lead to destruction of foreign antigens
define monocyte
- phagocytic cells that fight disease
- move from bloodstream into tissues + dispose of dead + dying cells + other tissue debris by phagocytosis
define megakaryocytes
giant cells with multi lobed nuclei
- main function is to help blood clot
what are the 4 major plasma proteins? and which 2 are clotting proteins?
- albumin
- globulins
- fibrinogen (clotting protein)
- prothrombin (clotting protein)
what does albumin do?
maintains proper proportion (and concentration) of water in the blood
- cannot pass easily through capillary walls
define edema
swelling that results when too much fluid from the blood “leaks” out into the tissues
define globulins
3 types: alpha, beta, gamma globulins
define gamma globulins
aka immunoglobulins which are antibodies:
IgG - found in high concentration in plasma)
IgA - found in breast milk, saliva, tears, and respiratory mucuous)
IgM
IgD
IgE
define electrophoresis
separates immunoglobulins from plasma
- electrical current passes through a solution of plasma (separated by size and charge)
define plasmapheresis
process of separating plasma from cells
define packed red cells
whole blood with most of its plasma
define hemolysis
breakdown of the red blood cells
define the Rh factor
Rh+ = person who is born with the Rh antigen
Rh- = person who is born without the Rh antigen
define coagulation
aka blood clotting, final product of this process is a fibrin clot from the plasma protein fibrinogen
define serum
clear fluid related to plasma
define anticoagulant substances
in the blood inhibit blood clotting so clots do not form
define heparin
produced by tissue cells (especially in liver)
bas/o
base
chrom/o
color
coagul/o
clotting
cyt/o
cell
esosin/o
red, dawn, rosy
erythr/o
red
granul/o
granules
hem/o
hemat/o
blood
hemoglobin/o
hemoglobin
is/o
same, equal
kary/o
nucleus
leuk/o
white
mon/o
one, single
morph/o
shape, form
myel/o
bone marrow
neutr/o
neutral
nucle/o
nucleus
phag/o
eat, swallow
poikil/o
varied, irregular
sider/o
iron
spher/o
globe, around
thromb/o
clot
–apheresis
removal of carrying away
–blast
immature or embryonic cell
–cytosis
abnormal condition of cells
–emia
blood condition
–gen
giving rise to; producing
–globin
–globulin
protein
–lytic
pertaining to destruction
–oid
derived, related to, or originating from
–osis
abnormal condition
–penia
deficiency
–phage
eat, swallowing
–philia
attraction for (increase in number cells)
–phoresis
carrying, transmission
–poiesis
formation
–stasis
stop, controlling