L23: Cancer Flashcards
Def of Cancer
Indicators of population impact of Cancer
Worldwide, cancer is a leading cause of death.
…
More than 70% of all cancer deaths occurred in ……
low & middle income countries
In developed countries, it is the …. leading cause of death next to CVD
2nd
In developing world, it is the …. cause of death.
4th
There is steady Increase in incidence and mortality of cancer that could be explained by:
❶ Advanced techniques for case-finding & detection
❷ Marked demographic aging
❸ Changes in life style & environment
The most frequent types of cancer In Males worldwide are
lung, stomach, liver, colorectal, oesophagus, prostate
The most frequent types of cancer In Females worldwide are
breast, lung, stomach, colorectal and cervical
Etiology of Cancer
The definite etiology of cancers in man are unknown
RF of Cancer
Genetic Factors Predispsoing to Cancer
Genetic Factors Predispsoing to Cancer
- Familial Tendency
there are familial tendencies for certain cancer as cancer breast, colon, prostate & lung
Genetic Factors Predispsoing to Cancer
- Chromosomal Deletion
- deletion of chromosome 13 in retinoblastoma
- deletion of chromosome 11 in Wilms’ tumor.
Environmental Factors Predispsoing to Cancer
Environmental Factors Predispsoing to Cancer
- Physical Factors
Environmental Factors Predispsoing to Cancer
- Physical Factors (Radiation)
Environmental Factors Predispsoing to Cancer
- Physical Factors (Mechsnical Factors)
include
❶ Chronic friction.
❷ Trauma, irritation .
❸ Inflammation as peptic ulcer & chronic cervicitis
Environmental Factors Predispsoing to Cancer
- Chemical Factors
Environmental Factors Predispsoing to Cancer
- Physical Factors (Tobacco)
Increased risk of cancer lung, mouth, larynx, stomach, pancreas & urinary bladder
Environmental Factors Predispsoing to Cancer
- Physical Factors (Air Pollution)
Environmental Factors Predispsoing to Cancer
- Physical Factors (Other Carcinogens)
Usually occupational as asphalt, tar, soot, dyes, etc.
Environmental Factors Predispsoing to Cancer
- Physical Factors (Hormones)
Environmental Factors Predispsoing to Cancer
- Physical Factors (Dietary Chemicals)
Environmental Factors Predispsoing to Cancer
- Biological Factors
Environmental Factors Predispsoing to Cancer
- Biological Factors (Viral Infections)
Environmental Factors Predispsoing to Cancer
- Biological Factors (HPV)
main cause of cervical cancer
Environmental Factors Predispsoing to Cancer
- Biological Factors (HBV & HCV)
inc risk of cancer liver
Environmental Factors Predispsoing to Cancer
- Biological Factors (HIV)
inc risk of cancer, as lymphoma & Kaposi’s sarcoma
Environmental Factors Predispsoing to Cancer
- Biological Factors (EBV)
inc risk of lymphoma
Environmental Factors Predispsoing to Cancer
- Biological Factors (HHV8)
inc risk of Kaposi’s sarcoma
Environmental Factors Predispsoing to Cancer
- Biological Factors (Parasitic Infections)
Environmental Factors Predispsoing to Cancer
- Biological Factors (S. Hematobium)
inc risk of cancer bladder
Environmental Factors Predispsoing to Cancer
- Biological Factors (Liver Fluke)
inc risk of hepatic angiosarcoma
Environmental Factors Predispsoing to Cancer
- Biological Factors (Bacterial Infections)
Environmental Factors Predispsoing to Cancer
- Biological Factors (H.Pylori)
may predispose to cancer stomach & lymphoma in the stomach lining
Environmental Factors Predispsoing to Cancer
- Biological Factors (Bacterial flora of intestine)
- may change some chemicals in food into carcinogens which may predispose to cancer colon
Prevention & control of Cancer
- Primary
- Secondary
- Tertiary
Prevention & control of Cancer
- Primary Prevention
Prevention & control of Cancer
- Primary Prevention (Air Sanitation)
Prevention & control of Cancer
- Primary Prevention (Smoking Control)
Antismoking program
Prevention & control of Cancer
- Primary Prevention (Drug Control)
Prevention & control of Cancer
- Primary Prevention (Radiation)
Prevention & control of Cancer
- Primary Prevention (Chemical Carcinogens)
Prevention & control of Cancer
- Primary Prevention (Medical Care)
Health appraisal: for early diagnosis and treatment of
precancerous lesions as leucoplakia, adenoma, peptic ulcer
Prevention & control of Cancer
- Primary Prevention (Specifc Prevention)
Prevention & control of Cancer
- Primary Prevention (Health Education)
Prevention & control of Cancer
- Primary Prevention (Legislations)
Danger Signals of Cancer
❶ Lump or mass or sore which not get better .
❷ Change in wart mole.
❸ Blood Loss from any nature orifice .
❹ Persistent cough, hoarseness of voice .
❺ Persistent change in digestive bowel habit.
❻ Unexplained loss of weight .
Prevention & control of Cancer
- Secondary Prevention
Screening Test Can be Used for At-Risk Individuals or Groups as ……
❶ High-risk or at-risk occupational groups.
❷ Cases with precancerous lesions.
❸ Cases with positive family history of cancer .
❹ Specific age groups as women aged ≥50 years for cancer cervix .
Prevention & control of Cancer
- Tertiary Prevention
❶ Surgery
❷ Radiotherapy
❸ Chemotherapy
❹ Hormonal therapy
❺ Immune therapy
❻ Rehabilitation