KEY ASSOCIATION IV

Question 1

Hereditary harmless jaundice

Answer 1

Gilbert syndrome (benign congenital unconjugated
hyperbilirubinemia)

Question 2

Hemochromatosis

Answer 2

Multiple blood transfusions or hereditary HFE mutation
(can result in heart failure, “bronze diabetes,” and risk
of hepatocellular carcinoma)

Question 3

Pancreatitis (acute)

Answer 3

Gallstones, alcohol

Question 4

Pancreatitis (chronic)

Answer 4

Alcohol (adults), cystic fibrosis (kids)

Question 5

Microcytic anemia

Answer 5

Iron deficiency

Question 6

Autosplenectomy (fibrosis and shrinkage)

Answer 6

Sickle cell disease (hemoglobin S)

Question 7

Bleeding disorder with GpIb deficiency

Answer 7

Bernard-Soulier syndrome (defect in platelet adhesion to

von Willebrand factor)

Question 8

Hereditary bleeding disorder

Answer 8

von Willebrand disease

Question 9

DIC

Answer 9

Severe sepsis, obstetric complications, cancer, burns,

trauma, major surgery, acute pancreatitis, APL

Question 10

Malignancy associated with noninfectious fever

Answer 10

Hodgkin lymphoma

Question 11

Type of Hodgkin lymphoma

Answer 11

Nodular sclerosis (vs mixed cellularity, lymphocytic
predominance, lymphocytic depletion)

Question 12

t(14;18)

Answer 12

Follicular lymphomas (BCL-2 activation, anti-apoptotic
oncogene)

Question 13

t(8;14)

Answer 13

Burkitt lymphoma (c-myc fusion, transcription factor
oncogene)

Question 14

Type of non-Hodgkin lymphoma

Answer 14

Diffuse large B-cell lymphoma

Question 15

1° bone tumor (adults)

Answer 15

Multiple myeloma

Question 16

Age ranges for patient with ALL/CLL/AML/CML

Answer 16

ALL: child, CLL: adult > 60, AML: adult ∼ 65, CML: adult 45–85

Question 17

Malignancy (kids)

Answer 17

Leukemia, brain tumors

Question 18

Death in CML

Answer 18

Blast crisis

Question 19

t(9;22)

Answer 19

Philadelphia chromosome, CML (BCR-ABL oncogene,
tyrosine kinase activation), more rarely associated with
ALL

Question 20

Vertebral compression fracture

Answer 20

Osteoporosis (type I: postmenopausal woman; type II: elderly man or woman)

Question 21

HLA-B27

Answer 21

Psoriatic arthritis, ankylosing spondylitis, IBD-associated

arthritis, reactive arthritis (formerly Reiter syndrome)

Question 22

Death in SLE

Answer 22

Lupus nephropathy

Question 23

Tumor of infancy

Answer 23

Strawberry hemangioma (grows rapidly and regresses
spontaneously by childhood)

Question 24

Actinic (solar) keratosis

Answer 24

Precursor to squamous cell carcinoma

Question 25

Cerebellar tonsillar herniation

Answer 25

Chiari I malformation

Question 26

Atrophy of the mammillary bodies

Answer 26

Wernicke encephalopathy (thiamine deficiency causing
ataxia, ophthalmoplegia, and confusion)