CLASSIC/RELEVANT TX III

Question 1

Chronic myelogenous leukemia

Answer 1

Imatinib

Question 2

Acute promyelocytic leukemia (M3)

Answer 2

All-trans retinoic acid, arsenic trioxide

Question 3

Drug of choice for anticoagulation in pregnancy or renal failure

Answer 3

Low-molecular-weight heparin

Question 4

Heparin reversal

Answer 4

Protamine sulfate

Question 5

Immediate anticoagulation

Answer 5

Heparin

Question 6

Long-term anticoagulation

Answer 6

Warfarin, dabigatran, rivaroxaban and apixaban

Question 7

Warfarin reversal

Answer 7

Fresh frozen plasma (acute), vitamin K (non-acute)

Question 8

Cyclophosphamide-induced hemorrhagic cystitis

Answer 8

Mesna

Question 9

HER2/neu ⊕ breast cancer

Answer 9

Trastuzumab

Question 10

Osteoporosis

Answer 10

Calcium/vitamin D supplementation (prophylaxis);
bisphosphonates, PTH analogs, SERMs, calcitonin,
denosumab (treatment)

Question 11

Osteomalacia/rickets

Answer 11

Vitamin D supplementation

Question 12

Chronic gout

Answer 12

Xanthine oxidase inhibitors (eg, allopurinol, febuxostat);

pegloticase; probenecid

Question 13

Acute gout attack

Answer 13

NSAIDs, colchicine, glucocorticoids

Question 14

Neural tube defect prevention

Answer 14

Prenatal folic acid

Question 15

Migraine

Answer 15

Abortive therapies (eg, sumatriptan, NSAIDs); prophylaxis

eg, propranolol, topiramate, CCBs, amitriptyline

Question 16

Multiple sclerosis

Answer 16

Disease-modifying therapies (eg, β-interferon, natalizumab); for acute flares, use IV steroids

Question 17

Tonic-clonic seizures

Answer 17

Levetiracetam, phenytoin, valproate, carbamazepine

Question 18

Absence seizures

Answer 18

Ethosuximide

Question 19

Trigeminal neuralgia (tic douloureux)

Answer 19

Carbamazepine

Question 20

Malignant hyperthermia

Answer 20

Dantrolene

Question 21

Anorexia

Answer 21

Nutrition, psychotherapy, SSRIs

Question 22

Bulimia nervosa

Answer 22

SSRIs

Question 23

Alcoholism

Answer 23

Disulfiram, acamprosate, naltrexone, supportive care

Question 24

ADHD

Answer 24

Methylphenidate, amphetamines, CBT, atomoxetine, guanfacine, clonidine

Question 25

Alcohol withdrawal

Answer 25

Long-acting benzodiazepines

Question 26

Bipolar disorder

Answer 26

Mood stabilizers (eg, lithium, valproic acid, carbamazepine), atypical antipsychotics

Question 27

Depression

Answer 27

SSRIs (first-line)

Question 28

Generalized anxiety disorder

Answer 28

SSRIs, SNRIs (first line); buspirone (second line)

Question 29

Schizophrenia (positive symptoms)

Answer 29

Typical and atypical antipsychotics

Question 30

Schizophrenia (negative symptoms)

Answer 30

Atypical antipsychotics