IMPORTANT CYTOKINES Flashcards
acute cytokines? and what do they recruit?
IL-1, IL-6, TNF-alpha
IL-8, IL-12
causes fever, acute inflammation
activates endothelium to express adhesion molecules
induces chemokine secretion to recruit WBCs
also called osteoclast activating factor
IL-1
causes fever and stimulates product of acute phase proteins
IL-6
activates endothelium
causes WBC recruitment, vascular leak
TNF-alpha
major chemotactic factor for neutrophil
IL-8
induces differentiation of T cells into Th1 cells
activates NK cells
IL-12
stimulates growth of helper, cytotoxic, and regulatory T cells and NK cells
IL-2
supports growth and differentiation of bone marrow stem cells, functions like GM-CSF
IL-3
secreted by NK cells and T cells in response to antigen or IL-12 from macrophage
stimulates macrophages to kill phagocytksed pathogens
inhibits differentiation of Th2 cells
interferon gamma
induces differentiation of T cells into Th (helper) 2 cells
promotes growth of B cells
enhances class switching to IgE and IgG
IL-4
promotes growth and differentiation of B cells
enhances class switching to IgA
stimulates growth and differentiation of eosinophils
IL-5
attenuates inflammatory response
decreases expression of MHC class II and Th1 cytokines
inhibits activated macrophages and dendritic cells also secreted by regulatory T cells
IL-10
