CARDIAC MEDS

Question 1

direct inhibition of Na/K ATPase leads to indirect inhibition of Na/Ca exchanger, increases calcium leads to positive inotropy. Stimulates vagus nerve decreasing heart rate

used for HF increasing contractility, atrial fibrillation (decrease conduction at AV node and depression of SA node)

Answer 1

digoxin, cardiac glycosides

Question 2

quinidine, procainamide, disopyramide

moderate Na channel blockage

used for:both atrial and ventricular arrhythmias

Answer 2

antiarrhythmic class IA

Question 3

lidocaine, mexiletine

weak Na+ channel blockade

used for:acute ventricular arrhythmias

Answer 3

antiarrhythmic class IB

Question 4

Flecainide, Propafenone

strong Na+ channel blockade

used for:SVTs like fib, last resort in refractory VT

Answer 4

antiarrhythmic class IC

Question 5

diltiazem, verapamil

decrease conduction velocity, increase ERP, increase PR interval

used for: prevention of nodal arrhythmias, rate control in atrial fibrillation

Answer 5

antiarrhythmic class IV

Question 6

increases potassium out of the cell

effective in torsades de pointes, digoxin toxicity

Answer 6

adenosine, antiarrhythmics

Question 7

effective in torsades de pointes and digoxin toxicity

Answer 7

magnesium

Question 8

IVabradine prolongs slow depolarization

chronic stable angina in patients who cannot take b-blockers

Answer 8

Ivabradine

Question 9

metoprolol, propanolol, esmolol, atenolol, timolol, carvedilol

decrease SA and AV nodal activity by decreasing cAMP

used: SVT, ventricular rate control for atrial fibrillation and atrial flutter

Answer 9

antiarrhythmic class 2, B-blockers

Question 10

amiodarone, Ibutilde, dofetilide, sotalol (AIDS)

increase AP duration, increase ERP, increase QT interval

used: atrial fib, atrial flutter, vtach

Answer 10

antiarrhythmic class 3, potassium channel blockers