Intro To Antibacterial Drugs

Question 1

Some antibiotics disrupt the bacterial wall, what are they called?

Answer 1

Beta Lactams which contain a beta lactam ring

Question 2

What do beta lactams do?

Answer 2

Binds to penicillin binding proteins

Interferes with synthesis of peptidoglycan and inhibits transpeptidase
Disrupting the cell wall

Question 3

What antibiotics disrupt bacterial protein synthesis?

Answer 3

-Tetracyclines which compete with tRNA for A site on ribosome

-Amphenicola inhibit peptide bond formation

-Macrolides inhibit translocation of ribosome

Question 4

Name the multiple mechanisms used in bacterial resistance.

Answer 4

Drug efflux pumps

Inactivation of a drug by bacterial enzymes

Alteration of bacterial cell drug targets

Inhibition of drug uptake into the cell