Intro To Pharmacology Pt 1

Question 1

What is the respective concept pretty much

Answer 1

Lock and key theory

Question 2

What are receptors

Answer 2

Proteins with binding sites that are receptive to ligands

Question 3

Four types of receptors

Answer 3

Ligand gated ion channels

G protein coupled receptors

Kinase linked receptors

Nuclear receptors

Question 4

We know how hormones come from and travel, what about neurotransmitters?

Answer 4

Synthesised in presumptive neurone and stored in vesicles

Ca2+ influx triggers exocytosis and diffuse through synaptic cleft

After binding to post synaptic receptors they are broken down or returned to stop transmission

Question 5

How are neurotransmitters removed from transmission?

Answer 5

Diffusion

Reuptake

Enzymatic degradation

Question 6

Name six types of main category neurotransmitters

Answer 6

Acetylcholine

Monoamines

Amino acids

Neuropeptides

Purines

Soluble gases

Question 7

What certain amino acids are neuroactive and their percentages for inhibitory and excitatory transmission?

Answer 7

GABA accounts for 40% inhibitory transmission

Glutamate accounts for 50% excitstory transmission

Question 8

Difference between adrenaline and noradrenaline?

Answer 8

Noradrenaline is a neurotransmitter and adrenaline is a hormone

Question 9

Two types of acetylcholine receptors and what kind of receptors are they?

Answer 9

(Nicotinic) nAChR - Ligand gated ion channel permeable to Na+ ions

(Muscarinic) mAChR - GPCR

Question 10

What does it mean when nAChR is pentameric?

Answer 10

Means it has 5 subunits alpha beta etc

Question 11

What types of Glutamate receptors are there?

Answer 11

Ionotropic named after selective ligands similarly to AChR (AMPA,NMDA,Kainate)

Ionotropic receptors open cation channel

Question 12

Difference between GABAa and GABAb receptors?

Answer 12

A is ionotropic and B is metabotropic