Intracellular Signalling 4

Question 1

What are the four types of receptors?

Answer 1

1.Ligand-gated ion channels (ionotropic receptors)
2.G protein coupled receptors (metabotrophic)
3.Kinase linked receptors
4.Nuclear receptors

Question 2

Tell me about ligand gated ion channel coupled receptors

Answer 2

Opens or closes in response to binding of SMs
Allowing flows across membrane and changing membrane potential to produce an electrical current

Question 3

Example of Logan’s gated ion channels

Answer 3

Nicotinic acetyl choline receptors
GABA receptors
Glutamate receptors

Question 4

When post synaptic neuron causes change in conformation that allows ion channel to open, what happens?

Answer 4

Leads to depolarisation or hyper polarisation

Question 5

What is the largest group of enzyme coupled receptors?

Answer 5

Largest group is receptor tyrosine kinases (RTKs) and binding of SM is called dimerisation

Question 6

How do enzyme coupled receptors work?

Answer 6

Receptor binds signalling molecule

This leads to enzyme activity being switched on intracellularly leading to pathways etc

Question 7

What does activation of RTKs do?

Answer 7

Activation of RTKs stimulate formation of intracellular signalling complex

Question 8

What do most RTKs activate?

Answer 8

Monomeric GTPase Ras which leads to MAPkinase signalling module to be activated leading to activation of loads of proteins