III: Poxviruses

Question 1

Name 6 pathogens with bioterrorism potential designated as Category A agents by the CDC.

Answer 1

Bacillus anthracis, Botulinum toxin, Yersinia pestis, Francisella tularensis, Small pox, viral hemorrhagic fevers

Question 2

Name the hosts associated with small pox.

Answer 2

Humans only

Question 3

Name three strategies for developing a bioweapon.

Answer 3

Enhance virulence of known pathogen, Construction of microbe by DNA technology, Construction of de novo pathogen from oligonucleotides

Question 4

What is the cause of small pox?

Answer 4

Variola major

Question 5

What is the treatment for Bacillus anthracis?

Answer 5

Fluoroquinolone or Tetracycline

Question 6

What is the treatment for Botulinum toxin poisoning?

Answer 6

Equine antitoxin

Question 7

What is the treatment for Francisella tularensis?

Answer 7

Fluoroquinolone or Tetracycline

Question 8

What is the treatment for smallpox?

Answer 8

Passive immunization (IVIG) from immunized individuals

Question 9

Which disease? Aerosolized spores are the infectious form

Answer 9

Bacillus Anthracis

Question 10

Which disease? Delivered as aerosol for bioterrorism purposes, no person-to-person transmission, bacteria is infectious form

Answer 10

Francisella tularensis

Question 11

Which disease? Fever and lymphadenopathy with 30-60% fatality, no safe vaccine available

Answer 11

Francisella tularensis

Question 12

Which disease? Flaccid paralysis

Answer 12

Botulinum

Question 13

Which disease? Globally eradicated in 1976

Answer 13

Small Pox

Question 14

Which disease? Gram-positive bacillus that produces spores that can survive for decades in the soil

Answer 14

Bacillus Anthracis

Question 15

Which disease? High fever, prostration, pustular rash that scabs and forms deep scars, person-to-person transmission; fatality up to 40%

Answer 15

Small Pox

Question 16

Which disease? High mortality possible, vaccines in development, currently no effective treatment

Answer 16

Viral hemorrhagic fevers

Question 17

Which disease? Human to human or animal to human transmission

Answer 17

Viral hemorrhagic fevers

Question 18

Which disease? Large, enveloped DNA virus

Answer 18

Small Pox

Question 19

Which disease? May be protected against with a live-attenuated virus that may be administered following exposure

Answer 19

Small Pox

Question 20

Which disease? Produces cutaneous and respiratory disease

Answer 20

Bacillus Anthracis

Question 21

Which disease? Rash resulting from inflammatory mediators and cell-mediated immunity targeting infected cells

Answer 21

Small Pox

Question 22

Which disease? Three different presentations, significant person-to-person transmission

Answer 22

Yersinia Pestis

Question 23

Which disease? Toxin in aerosol or food with no person-to-person transmission

Answer 23

Botulinum

Question 24

Which disease? Toxoid vaccine available to lab personnel

Answer 24

Botulinum

Question 25

Which disease? Vaccine consists of cell-free filtrates; not typically available to the public; not effective after exposure

Answer 25

Bacillus Anthracis

Question 26

Which disease? Vaccine consists of whole cells; generally used only among lab personnel

Answer 26

Yersinia Pestis