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Infectious Disease > III: Hepatitis > Flashcards

III: Hepatitis Flashcards

1
Q

Adults with recent HAV exposure can be given ______.

A

Active (vaccine) and Passive (immune globulin) Immunization

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2
Q

Describe the HAV vaccine.

A

killed virus with capsid protein antigens

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3
Q

Describe the HBV vaccine.

A

Recombinant vaccine

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4
Q

Describe the relevant virology for Hepatitis A, including the virus family and genomic content.

A

Picornavirus, capsid, (+)ssRNA

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5
Q

Describe the relevant virology for Hepatitis B, including the virus family and genomic content.

A

Hepadnovirus, enveloped, ssDNA/dsDNA

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6
Q

Describe the relevant virology for Hepatitis C, including the virus family and genomic content.

A

Flavivirus, enveloped, RNA

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7
Q

Describe the relevant virology for Hepatitis D, including the virus family and genomic content.

A

Envelope, circular RNA

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8
Q

Describe the relevant virology for Hepatitis E, including the virus family and genomic content.

A

Hepevirus, capsid, (+)ssRNA

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9
Q

HDV coinfection with HBV has _____ outcomes compared to HDV superinfection with HBV.

A

better

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10
Q

Hepatitis D virus encodes ___ antigen

A

Delta

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11
Q

How is HAV diagnosed?

A

stool HAVAg, antiHAV antibodies

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12
Q

How is HCV diagnosed?

A

AntiHCV, stool RT-PCR

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13
Q

How is HDV diagnosed?

A

AntiHDV, DeltaAg

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14
Q

How is HEV diagnosed?

A

AntiHEV, stool RT-PCR

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15
Q

In hepatitis A, jaundice is more common in _____ patients.

A

older

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16
Q

In hepatitis B, the incidence of chronic infection ______ with increasing age

A

decreases

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17
Q

In hepatitis B, the incidence of symptomatic acute infection ______ with increasing age

A

increases

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18
Q

Name four categories of HCV Direct Acting Antivirals

A

HCV protease inhibitors, NS5A inhibitors, NS5B inhibitors, NS3/4A inhibitors

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19
Q

Name the three sets of enzymes involved in hepatitis B replication in order;

A

Host DNA repair enzymes; host DNA-dependent RNA polymerase; viral reverse transcriptase

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20
Q

Which HBV marker? Indicator of resolution of hepatitis and favorable prognosis

A

HBVeAb

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21
Q

Which HBV marker? Marker associated with infectivity

22
Q

Which HBV marker? Marker of immune protection

23
Q

Which HBV marker? Marker of infection

A

HBVcAg, HBVcAb

24
Q

Which HBV marker? Marker of infection or immunization

A

HBVsAg, HBVsAb

25
Which HBV treatment? dATP analogue
Adefovir
26
Which HBV treatment? Guanine analogue
Entecavir
27
Which HBV treatment? Infected neonate
HBV vaccine
28
Which HBV treatment? NRTI
Lamivudine, Tenofovir
29
Which HBV treatment? Treatment with limited efficacy
IFN/Pegylated-IFN
30
Which HCV treatment? Name the components of Abbvie's Viekira Pak formulation
paritaprevir (NS3/4A), Ombitasvir (NS5A), Dasabuvir (NS5B)
31
Which HCV treatment? Name the components of Gilead's Harvoni formulation
sofosbuvir (NS5B), ledipasvir (NS5A)
32
Which HCV treatment? Used 2011-2014
Pegylated IFN and Ribavirin and Protease Inhibitor (telapravir or bocepravir)
33
Which HCV treatment? Used prior to 2011
Pegylated IFN and Ribavirin
34
Which hepatitis viruses have a vaccine?
A, B
35
Which hepatits virus? Acute infections often subclinical; 80% progress to chronic state
C
36
Which hepatits virus? Chronic hepatitis in ~20%
B
37
Which hepatits virus? Fecal-oral transmission
A, E
38
Which hepatits virus? High (20%) mortality due to fulminant hepatitis occurring in 3rd trimester of pregnancy
E
39
Which hepatits virus? Most common reason for liver transplant in the US
C
40
Which hepatits virus? Most frequent cause of hepatitis in the US
A
41
Which hepatits virus? No chronic state
A, E
42
Which hepatits virus? Parenteral transmission, especially blood transfusions, IV drug use, perinatal, and sexual contact
C
43
Which hepatits virus? Parenteral transmission, especially sexual contact (also perinatal)
B
44
Which hepatits virus? Parenteral, sexual
D
45
Which hepatits virus? Replication involves cccDNA synthesized by _______
B; host DNA repair enzymes
46
Which hepatits virus? Requires coinfection with Hepatitis __
D; B
47
Which hepatits virus? Uses reverse transcriptase to produce its genome
B
48
Which vaccine? Prevents against HDV
HBV
49
Which vaccine? Recommended for all children in the US and visitors to developing countries
HAV
50
Which vaccine? Recommended for health care workers and infants born to infected mothers
HBV

Infectious Disease (21 decks)

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