III: Hepatitis Flashcards
Adults with recent HAV exposure can be given ______.
Active (vaccine) and Passive (immune globulin) Immunization
Describe the HAV vaccine.
killed virus with capsid protein antigens
Describe the HBV vaccine.
Recombinant vaccine
Describe the relevant virology for Hepatitis A, including the virus family and genomic content.
Picornavirus, capsid, (+)ssRNA
Describe the relevant virology for Hepatitis B, including the virus family and genomic content.
Hepadnovirus, enveloped, ssDNA/dsDNA
Describe the relevant virology for Hepatitis C, including the virus family and genomic content.
Flavivirus, enveloped, RNA
Describe the relevant virology for Hepatitis D, including the virus family and genomic content.
Envelope, circular RNA
Describe the relevant virology for Hepatitis E, including the virus family and genomic content.
Hepevirus, capsid, (+)ssRNA
HDV coinfection with HBV has _____ outcomes compared to HDV superinfection with HBV.
better
Hepatitis D virus encodes ___ antigen
Delta
How is HAV diagnosed?
stool HAVAg, antiHAV antibodies
How is HCV diagnosed?
AntiHCV, stool RT-PCR
How is HDV diagnosed?
AntiHDV, DeltaAg
How is HEV diagnosed?
AntiHEV, stool RT-PCR
In hepatitis A, jaundice is more common in _____ patients.
older
In hepatitis B, the incidence of chronic infection ______ with increasing age
decreases
In hepatitis B, the incidence of symptomatic acute infection ______ with increasing age
increases
Name four categories of HCV Direct Acting Antivirals
HCV protease inhibitors, NS5A inhibitors, NS5B inhibitors, NS3/4A inhibitors
Name the three sets of enzymes involved in hepatitis B replication in order;
Host DNA repair enzymes; host DNA-dependent RNA polymerase; viral reverse transcriptase
Which HBV marker? Indicator of resolution of hepatitis and favorable prognosis
HBVeAb
Which HBV marker? Marker associated with infectivity
HBVeAg
Which HBV marker? Marker of immune protection
HBVsAb
Which HBV marker? Marker of infection
HBVcAg, HBVcAb
Which HBV marker? Marker of infection or immunization
HBVsAg, HBVsAb
Which HBV treatment? dATP analogue
Adefovir
Which HBV treatment? Guanine analogue
Entecavir
Which HBV treatment? Infected neonate
HBV vaccine
Which HBV treatment? NRTI
Lamivudine, Tenofovir
Which HBV treatment? Treatment with limited efficacy
IFN/Pegylated-IFN
Which HCV treatment? Name the components of Abbvie’s Viekira Pak formulation
paritaprevir (NS3/4A), Ombitasvir (NS5A), Dasabuvir (NS5B)
Which HCV treatment? Name the components of Gilead’s Harvoni formulation
sofosbuvir (NS5B), ledipasvir (NS5A)
Which HCV treatment? Used 2011-2014
Pegylated IFN and Ribavirin and Protease Inhibitor (telapravir or bocepravir)
Which HCV treatment? Used prior to 2011
Pegylated IFN and Ribavirin
Which hepatitis viruses have a vaccine?
A, B
Which hepatits virus? Acute infections often subclinical; 80% progress to chronic state
C
Which hepatits virus? Chronic hepatitis in ~20%
B
Which hepatits virus? Fecal-oral transmission
A, E
Which hepatits virus? High (20%) mortality due to fulminant hepatitis occurring in 3rd trimester of pregnancy
E
Which hepatits virus? Most common reason for liver transplant in the US
C
Which hepatits virus? Most frequent cause of hepatitis in the US
A
Which hepatits virus? No chronic state
A, E
Which hepatits virus? Parenteral transmission, especially blood transfusions, IV drug use, perinatal, and sexual contact
C
Which hepatits virus? Parenteral transmission, especially sexual contact (also perinatal)
B
Which hepatits virus? Parenteral, sexual
D
Which hepatits virus? Replication involves cccDNA synthesized by _______
B; host DNA repair enzymes
Which hepatits virus? Requires coinfection with Hepatitis __
D; B
Which hepatits virus? Uses reverse transcriptase to produce its genome
B
Which vaccine? Prevents against HDV
HBV
Which vaccine? Recommended for all children in the US and visitors to developing countries
HAV
Which vaccine? Recommended for health care workers and infants born to infected mothers
HBV
