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Infectious Disease > III: Hepatitis > Flashcards

III: Hepatitis Flashcards

1
Q

Adults with recent HAV exposure can be given ______.

A

Active (vaccine) and Passive (immune globulin) Immunization

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2
Q

Describe the HAV vaccine.

A

killed virus with capsid protein antigens

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3
Q

Describe the HBV vaccine.

A

Recombinant vaccine

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4
Q

Describe the relevant virology for Hepatitis A, including the virus family and genomic content.

A

Picornavirus, capsid, (+)ssRNA

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5
Q

Describe the relevant virology for Hepatitis B, including the virus family and genomic content.

A

Hepadnovirus, enveloped, ssDNA/dsDNA

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6
Q

Describe the relevant virology for Hepatitis C, including the virus family and genomic content.

A

Flavivirus, enveloped, RNA

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7
Q

Describe the relevant virology for Hepatitis D, including the virus family and genomic content.

A

Envelope, circular RNA

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8
Q

Describe the relevant virology for Hepatitis E, including the virus family and genomic content.

A

Hepevirus, capsid, (+)ssRNA

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9
Q

HDV coinfection with HBV has _____ outcomes compared to HDV superinfection with HBV.

A

better

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10
Q

Hepatitis D virus encodes ___ antigen

A

Delta

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11
Q

How is HAV diagnosed?

A

stool HAVAg, antiHAV antibodies

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12
Q

How is HCV diagnosed?

A

AntiHCV, stool RT-PCR

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13
Q

How is HDV diagnosed?

A

AntiHDV, DeltaAg

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14
Q

How is HEV diagnosed?

A

AntiHEV, stool RT-PCR

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15
Q

In hepatitis A, jaundice is more common in _____ patients.

A

older

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16
Q

In hepatitis B, the incidence of chronic infection ______ with increasing age

A

decreases

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17
Q

In hepatitis B, the incidence of symptomatic acute infection ______ with increasing age

A

increases

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18
Q

Name four categories of HCV Direct Acting Antivirals

A

HCV protease inhibitors, NS5A inhibitors, NS5B inhibitors, NS3/4A inhibitors

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19
Q

Name the three sets of enzymes involved in hepatitis B replication in order;

A

Host DNA repair enzymes; host DNA-dependent RNA polymerase; viral reverse transcriptase

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20
Q

Which HBV marker? Indicator of resolution of hepatitis and favorable prognosis

A

HBVeAb

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21
Q

Which HBV marker? Marker associated with infectivity

A

HBVeAg

22
Q

Which HBV marker? Marker of immune protection

A

HBVsAb

23
Q

Which HBV marker? Marker of infection

A

HBVcAg, HBVcAb

24
Q

Which HBV marker? Marker of infection or immunization

A

HBVsAg, HBVsAb

25
Q

Which HBV treatment? dATP analogue

A

Adefovir

26
Q

Which HBV treatment? Guanine analogue

A

Entecavir

27
Q

Which HBV treatment? Infected neonate

A

HBV vaccine

28
Q

Which HBV treatment? NRTI

A

Lamivudine, Tenofovir

29
Q

Which HBV treatment? Treatment with limited efficacy

A

IFN/Pegylated-IFN

30
Q

Which HCV treatment? Name the components of Abbvie’s Viekira Pak formulation

A

paritaprevir (NS3/4A), Ombitasvir (NS5A), Dasabuvir (NS5B)

31
Q

Which HCV treatment? Name the components of Gilead’s Harvoni formulation

A

sofosbuvir (NS5B), ledipasvir (NS5A)

32
Q

Which HCV treatment? Used 2011-2014

A

Pegylated IFN and Ribavirin and Protease Inhibitor (telapravir or bocepravir)

33
Q

Which HCV treatment? Used prior to 2011

A

Pegylated IFN and Ribavirin

34
Q

Which hepatitis viruses have a vaccine?

A

A, B

35
Q

Which hepatits virus? Acute infections often subclinical; 80% progress to chronic state

A

C

36
Q

Which hepatits virus? Chronic hepatitis in ~20%

A

B

37
Q

Which hepatits virus? Fecal-oral transmission

A

A, E

38
Q

Which hepatits virus? High (20%) mortality due to fulminant hepatitis occurring in 3rd trimester of pregnancy

A

E

39
Q

Which hepatits virus? Most common reason for liver transplant in the US

A

C

40
Q

Which hepatits virus? Most frequent cause of hepatitis in the US

A

A

41
Q

Which hepatits virus? No chronic state

A

A, E

42
Q

Which hepatits virus? Parenteral transmission, especially blood transfusions, IV drug use, perinatal, and sexual contact

A

C

43
Q

Which hepatits virus? Parenteral transmission, especially sexual contact (also perinatal)

A

B

44
Q

Which hepatits virus? Parenteral, sexual

A

D

45
Q

Which hepatits virus? Replication involves cccDNA synthesized by _______

A

B; host DNA repair enzymes

46
Q

Which hepatits virus? Requires coinfection with Hepatitis __

A

D; B

47
Q

Which hepatits virus? Uses reverse transcriptase to produce its genome

A

B

48
Q

Which vaccine? Prevents against HDV

A

HBV

49
Q

Which vaccine? Recommended for all children in the US and visitors to developing countries

A

HAV

50
Q

Which vaccine? Recommended for health care workers and infants born to infected mothers

A

HBV

Infectious Disease (21 decks)

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