II: Retroviruses Flashcards
Do retroviruses contain an envelope? What is the capsid symmetry?
Yes; Icosahedral
How is HIV diagnosed?
ELISA and confirmatory Western Blot
How is viral load determined in HIV infection?
Quantitative RT-PCR
In AIDS-associated cancers, ______ cancers are increasing in incidence which _____ cancers are decreasing in incidence
AIDS-non-defining; AIDS-defining
Mutation in which receptor is protective against HIV infection?
CCR5
Name the 4 types of Adult T-Cell Leukemia/Lymphoma (ATL). Which is most common?
Acute, Chronic, Lymphomatous, Smoldering; Acute
Name the receptors used by HIV for entry into T cells.
CD4R, CXCR4 or CCR5
Name three AIDS-defining cancers.
Kaposi Sarcoma, Non-Hodgkin Lymphoma, Cervical Cancer
Name two diseases associated with HTLV.
Adult T-Cell Leukemia/Lymphoma (ATL), HTLV-1 Associated Myelopathy (HAM)
What aspect of management makes co-treatment of HIV and AIDS-related cancers challenging?
P450 metabolism interactions
What is appropriate treatment for Candida infection (oral thrush)?
Fluconazole
What is appropriate treatment for pneumocystis pneumonia?
TMP-SMX
What is the DNA structure of retroviruses?
2 copies of ssRNA (linear)
What is the suspected pathogen in the context of chorioretinitis in an immunocompromised patient?
CMV
When is the highest risk of HIV transmission?
During primary infection
