II: Anti-Retrovirals

Question 1

Which drug class? -gravir

Answer 1

Integrase Strand Transfer Inhibitors (INSTIs)

Question 2

Which drug class? -navir

Answer 2

Protease Inhibitors (PIs)

Question 3

Which drug class? Bind to non-catalytic pocket in reverse transcriptase

Answer 3

NNRTIs

Question 4

Which drug class? Bone marrow suppression, peripheral neuropathy, lactic acidosis

Answer 4

NRTIs

Question 5

Which drug class? CCR5 receptor antagonist

Answer 5

Entry Inhibitors/Maraviroc

Question 6

Which drug class? Common resistance due to point mutations in reverse transcriptase

Answer 6

NNRTIs

Question 7

Which drug class? Compete with host cell triphosphate nucleotides to access HIV reverse transcriptase

Answer 7

NRTIs

Question 8

Which drug class? GI disturbances, hyperlipidemia, hyperglycemia, hepatotoxicity

Answer 8

Protease Inhibitors (PIs)

Question 9

Which drug class? Hepatotoxicity and rash, CNS effects (some agents)

Answer 9

NNRTIs

Question 10

Which drug class? Increased liver enzymes, CK

Answer 10

Integrase Strand Transfer Inhibitors (INSTIs)

Question 11

Which drug class? Interferes with viral protein posttranslational processing

Answer 11

Protease Inhibitors (PIs)

Question 12

Which drug class? Must be administered subcutaneously

Answer 12

Fusion Inhibitors/Enfuvirtide

Question 13

Which drug class? Prevent viral processing of DNA strands and incorporation into host chromosome

Answer 13

Integrase Strand Transfer Inhibitors (INSTIs)

Question 14

Which drug class? Prevents HIV fusion with gp41 and cell entry

Answer 14

Fusion Inhibitors/Enfuvirtide

Question 15

Which drug class? Renally excreted

Answer 15

NRTIs

Question 16

Which drug class? Requires activation by cellular kinase

Answer 16

NRTIs

Question 17

Which drug class? Resistance due to use of CXCR4 receptor binding by virus

Answer 17

Entry Inhibitors/Maraviroc

Question 18

Which protease inhibitor inhibits cytochrome P450?

Answer 18

Ritonavir