III: Picornaviruses

Question 1

_____ antibodies block picornavirus disease.

Answer 1

IgG

Question 2

_____ antibodies block picornavirus infection.

Answer 2

IgA

Question 3

Bivalent OPV (bOPV) has increased protection against poliovirus serotypes __.

Answer 3

1 and 3

Question 4

Define the capsule symmetry, envelope presence, and genome for picornaviruses

Answer 4

icosahedral; non-enveloped; (+)ssRNA

Question 5

Describe the seasonality of enterovirus infections.

Answer 5

June to November

Question 6

Enteroviruses are acid-______ and transmitted by _____.

Answer 6

stable; respiratory secretions and fecal-oral

Question 7

Hand-foot-mouth disease is caused by ______

Answer 7

Enteroviruses

Question 8

Hepatitis A virus is acid-______ and transmitted by ______.

Answer 8

stable; fecal-oral

Question 9

Name four types of enteroviruses.

Answer 9

Echovirus, Cocksackievirus, Poliovirus, Eneterovirus

Question 10

Name the outcomes of poliovirus infection in the order of decreasing incidence.

Answer 10

Asymptomatic; Mild Illness; Aseptic meningitis; Acute flaccid paralysis

Question 11

Name the three categories of picornaviruses

Answer 11

Enteroviruses; Hepatitis A; Rhinoviruses

Question 12

Picornavirus genome replication is completed by _______.

Answer 12

Viral-encoded replicase (RNA-dependent RNA polymerase)

Question 13

Poliovirus involves a primary stage, manifesting with ______ and a secondary stage manifesting with _______.

Answer 13

shedding in feces 2-6 weeks; possible CNS infection

Question 14

Poliovirus serotype __ has been most widely eradicated

Answer 14

2

Question 15

Rhinoviruses are acid-_____ and transmitted by ______.

Answer 15

labile; fomites and respiratory secretions

Question 16

RNA replication occurs in the ____ of host cells.

Answer 16

cytoplasm

Question 17

There are an increased number of VAPP cases in regions using the ____ vaccine.

Answer 17

bOPV

Question 18

Which poliovirus vaccine consists of injected killed virus?

Answer 18

IPV/Salk

Question 19

Which poliovirus vaccine consists of oral live attenuated virus?

Answer 19

OPV/Sabin

Question 20

Which poliovirus vaccine? Can be used in immunocompromised patients

Answer 20

IPV/Salk

Question 21

Which poliovirus vaccine? Can revert to infectious virus

Answer 21

OPV/Sabin

Question 22

Which poliovirus vaccine? Contributes to Vaccine-Associated Paralytic Poliomyelitis (VAPP)

Answer 22

OPV/Sabin

Question 23

Which poliovirus vaccine? Induces IgA-mediated mucosal immunity

Answer 23

OPV/Sabin

Question 24

Which poliovirus vaccine? More expensive

Answer 24

IPV/Salk

Question 25

Which poliovirus vaccine? Requires injection

Answer 25

IPV/Salk

Question 26

Which virus? Fever/malaise, anorexia, sore throat, vesicles on hands/feet/mouth

Answer 26

Enteroviruses (Hand-foot-mouth disease)