III: Picornaviruses Flashcards
_____ antibodies block picornavirus disease.
IgG
_____ antibodies block picornavirus infection.
IgA
Bivalent OPV (bOPV) has increased protection against poliovirus serotypes __.
1 and 3
Define the capsule symmetry, envelope presence, and genome for picornaviruses
icosahedral; non-enveloped; (+)ssRNA
Describe the seasonality of enterovirus infections.
June to November
Enteroviruses are acid-______ and transmitted by _____.
stable; respiratory secretions and fecal-oral
Hand-foot-mouth disease is caused by ______
Enteroviruses
Hepatitis A virus is acid-______ and transmitted by ______.
stable; fecal-oral
Name four types of enteroviruses.
Echovirus, Cocksackievirus, Poliovirus, Eneterovirus
Name the outcomes of poliovirus infection in the order of decreasing incidence.
Asymptomatic; Mild Illness; Aseptic meningitis; Acute flaccid paralysis
Name the three categories of picornaviruses
Enteroviruses; Hepatitis A; Rhinoviruses
Picornavirus genome replication is completed by _______.
Viral-encoded replicase (RNA-dependent RNA polymerase)
Poliovirus involves a primary stage, manifesting with ______ and a secondary stage manifesting with _______.
shedding in feces 2-6 weeks; possible CNS infection
Poliovirus serotype __ has been most widely eradicated
2
Rhinoviruses are acid-_____ and transmitted by ______.
labile; fomites and respiratory secretions
RNA replication occurs in the ____ of host cells.
cytoplasm
There are an increased number of VAPP cases in regions using the ____ vaccine.
bOPV
Which poliovirus vaccine consists of injected killed virus?
IPV/Salk
Which poliovirus vaccine consists of oral live attenuated virus?
OPV/Sabin
Which poliovirus vaccine? Can be used in immunocompromised patients
IPV/Salk
Which poliovirus vaccine? Can revert to infectious virus
OPV/Sabin
Which poliovirus vaccine? Contributes to Vaccine-Associated Paralytic Poliomyelitis (VAPP)
OPV/Sabin
Which poliovirus vaccine? Induces IgA-mediated mucosal immunity
OPV/Sabin
Which poliovirus vaccine? More expensive
IPV/Salk
Which poliovirus vaccine? Requires injection
IPV/Salk
Which virus? Fever/malaise, anorexia, sore throat, vesicles on hands/feet/mouth
Enteroviruses (Hand-foot-mouth disease)
