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Infectious Disease > III: Picornaviruses > Flashcards

III: Picornaviruses Flashcards

1
Q

_____ antibodies block picornavirus disease.

A

IgG

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2
Q

_____ antibodies block picornavirus infection.

A

IgA

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3
Q

Bivalent OPV (bOPV) has increased protection against poliovirus serotypes __.

A

1 and 3

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4
Q

Define the capsule symmetry, envelope presence, and genome for picornaviruses

A

icosahedral; non-enveloped; (+)ssRNA

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5
Q

Describe the seasonality of enterovirus infections.

A

June to November

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6
Q

Enteroviruses are acid-______ and transmitted by _____.

A

stable; respiratory secretions and fecal-oral

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7
Q

Hand-foot-mouth disease is caused by ______

A

Enteroviruses

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8
Q

Hepatitis A virus is acid-______ and transmitted by ______.

A

stable; fecal-oral

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9
Q

Name four types of enteroviruses.

A

Echovirus, Cocksackievirus, Poliovirus, Eneterovirus

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10
Q

Name the outcomes of poliovirus infection in the order of decreasing incidence.

A

Asymptomatic; Mild Illness; Aseptic meningitis; Acute flaccid paralysis

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11
Q

Name the three categories of picornaviruses

A

Enteroviruses; Hepatitis A; Rhinoviruses

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12
Q

Picornavirus genome replication is completed by _______.

A

Viral-encoded replicase (RNA-dependent RNA polymerase)

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13
Q

Poliovirus involves a primary stage, manifesting with ______ and a secondary stage manifesting with _______.

A

shedding in feces 2-6 weeks; possible CNS infection

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14
Q

Poliovirus serotype __ has been most widely eradicated

A

2

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15
Q

Rhinoviruses are acid-_____ and transmitted by ______.

A

labile; fomites and respiratory secretions

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16
Q

RNA replication occurs in the ____ of host cells.

A

cytoplasm

17
Q

There are an increased number of VAPP cases in regions using the ____ vaccine.

A

bOPV

18
Q

Which poliovirus vaccine consists of injected killed virus?

A

IPV/Salk

19
Q

Which poliovirus vaccine consists of oral live attenuated virus?

A

OPV/Sabin

20
Q

Which poliovirus vaccine? Can be used in immunocompromised patients

A

IPV/Salk

21
Q

Which poliovirus vaccine? Can revert to infectious virus

A

OPV/Sabin

22
Q

Which poliovirus vaccine? Contributes to Vaccine-Associated Paralytic Poliomyelitis (VAPP)

A

OPV/Sabin

23
Q

Which poliovirus vaccine? Induces IgA-mediated mucosal immunity

A

OPV/Sabin

24
Q

Which poliovirus vaccine? More expensive

A

IPV/Salk

25
Q

Which poliovirus vaccine? Requires injection

A

IPV/Salk

26
Q

Which virus? Fever/malaise, anorexia, sore throat, vesicles on hands/feet/mouth

A

Enteroviruses (Hand-foot-mouth disease)

Infectious Disease (21 decks)

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