I: Herpesviruses

Question 1

Acyclovir is activated by ______.

Answer 1

Thymidine kinase

Question 2

Ganciclovir is activated by ____.

Answer 2

UL97 kinase

Question 3

Name the location of latency. CMV

Answer 3

Myeloid precursors

Question 4

Name the location of latency. EBV

Answer 4

B Cells

Question 5

Name the location of latency. HHV6/HHV7

Answer 5

T Cells

Question 6

Name the location of latency. HSV1/HSV2

Answer 6

Peripheral Neurons

Question 7

Name the location of latency. KSHV

Answer 7

B Cells, Endothelial Cells

Question 8

Name the location of latency. VZV

Answer 8

Peripheral Neurons

Question 9

Which antigen/gene in EBV? Links viral genome to cellular chromosome to ensure concurrent replication

Answer 9

EBNA1

Question 10

Which antigen/gene in EBV? Transcription factor that activates latent viral genes and cellular activator genes

Answer 10

EBNA2

Question 11

Which virus may cause infectious mononucleosis with heterophilic antibodies?

Answer 11

EBV

Question 12

Which virus? Acidophilic inclusions

Answer 12

HSV, VZV

Question 13

Which virus? Basophilic inclusions

Answer 13

CMV

Question 14

Which virus? Intranuclear and intracytoplasmic inclusions

Answer 14

CMV, HHV-6