I: Antimicrobials

Question 1

Name two antimicrobial drug classes notable for CYP450 inhibition.

Answer 1

Sulfonamides, Macrolides

Question 2

What is the spectrum of the drug class? Aminoglycosides

Answer 2

Extended

Question 3

What is the spectrum of the drug class? Bacitracin

Answer 3

Narrow

Question 4

What is the spectrum of the drug class? Carbapenems

Answer 4

Extended

Question 5

What is the spectrum of the drug class? Cephalosporins

Answer 5

Extended

Question 6

What is the spectrum of the drug class? Chloramphenicol

Answer 6

Broad

Question 7

What is the spectrum of the drug class? Clindamycin

Answer 7

Narrow

Question 8

What is the spectrum of the drug class? Daptomycin

Answer 8

Narrow

Question 9

What is the spectrum of the drug class? Extended-Spectrum Penecillins

Answer 9

Extended

Question 10

What is the spectrum of the drug class? Fluoroquinolones

Answer 10

Extended

Question 11

What is the spectrum of the drug class? Macrolides

Answer 11

Extended

Question 12

What is the spectrum of the drug class? Metronidazole

Answer 12

Narrow

Question 13

What is the spectrum of the drug class? Monobactams

Answer 13

Narrow

Question 14

What is the spectrum of the drug class? Penicillin V, G

Answer 14

Narrow

Question 15

What is the spectrum of the drug class? Penicillinase-Resistant Penicillins

Answer 15

Narrow

Question 16

What is the spectrum of the drug class? Polymyxins

Answer 16

Narrow

Question 17

What is the spectrum of the drug class? Streptogranins

Answer 17

Extended

Question 18

What is the spectrum of the drug class? Sulfonamides

Answer 18

Broad

Question 19

What is the spectrum of the drug class? Tetracyclines

Answer 19

Broad

Question 20

What is the spectrum of the drug class? Trimethoprim

Answer 20

Broad

Question 21

What is the spectrum of the drug class? Vancomycin

Answer 21

Narrow

Question 22

Which drug class has the following mechanism of action? Bactericidal disruption of cell membrane of gram(+) cocci

Answer 22

Daptomycin

Question 23

Which drug class has the following mechanism of action? Bactericidal formation of toxic radicals that damage DNA (2)

Answer 23

Metronidazole, Nitrofurantoin

Question 24

Which drug class has the following mechanism of action? Bactericidal inhibition of bacterial DNA gyrase and topoisomerase IV

Answer 24

Fluoroquinolones

Question 25

Which drug class has the following mechanism of action? Bactericidal inhibition of protein synthesis by binding the 30S ribosomal subunit

Answer 25

Aminoglycosides

Question 26

Which drug class has the following mechanism of action? Bactericidal lysis of bacteria by membrane disruption

Answer 26

Polymyxins

Question 27

Which drug class has the following mechanism of action? Bacteriostatic inhibition of folate synthesis

Answer 27

Sulfonamides

Question 28

Which drug class has the following mechanism of action? Bacteriostatic inhibition of protein synthesis by binding of 30S subunit (prevents attachment of aminoacyl t-RNA)

Answer 28

Tetracyclines

Question 29

Which drug class has the following mechanism of action? Bacteriostatic inhibition of protein synthesis by binding of 50S subunit (5)

Answer 29

Chloramphenicol, Lincosamides (Clindamycin), Oxazolidinones (Linezolid), Streptogramins, Macrolides

Question 30

Which drug class has the following mechanism of action? Inhibit cell wall synthesis by binding to D-Ala-D-Ala portion of cell wall precursors

Answer 30

Vancomycin

Question 31

Which drug class has the following mechanism of action? Inhibit cell wall synthesis by interfering with peptidoglycan cross-linking

Answer 31

Penicillins, Cephalosporins, Carbapenems

Question 32

Which drug class has the following mechanism of action? Inhibit cell wall synthesis by interfering with peptidoglycan cross-linking by bindng penicillin binding protein 3

Answer 32

Monobactams/Aztrenam

Question 33

Which drug class has the following mechanism of action? Inhibits dihydrofolate reductase

Answer 33

Trimethoprim

Question 34

Which drug class is associated with the following adverse effect(s): abnormal bone development, superinfection, photosensitivity

Answer 34

Tetracyclines

Question 35

Which drug class is associated with the following adverse effect(s): Disulfiram-like reaction, metallic taste

Answer 35

Metronidazole

Question 36

Which drug class is associated with the following adverse effect(s): Gray Baby syndrome in premature infants, high toxicity

Answer 36

Chloramphenicol

Question 37

Which drug class is associated with the following adverse effect(s): Hemolysis in G6PD deficiency, nephrotoxicity, infant kernicterus

Answer 37

Sulfonamides

Question 38

Which drug class is associated with the following adverse effect(s): high nephrotoxicity and neurotoxicity

Answer 38

Polymyxins

Question 39

Which drug class is associated with the following adverse effect(s): Megaloblastic anemia, leukopenia, granulocytopenia

Answer 39

Trimethoprim

Question 40

Which drug class is associated with the following adverse effect(s): nephrotoxicity, ototoxicity, neuromuscular blockage, teratogenicity

Answer 40

Aminoglycosides

Question 41

Which drug class is associated with the following adverse effect(s): Prolonged QT, eosinophilia

Answer 41

Macrolides

Question 42

Which drug class is associated with the following adverse effect(s): Red Man syndrome

Answer 42

Vancomycin

Question 43

Which drug class is associated with the following adverse effect(s): rhabdomyolysis, myopathy

Answer 43

Daptomycin

Question 44

Which drug class is associated with the following adverse effect(s): Serotonin Syndrome, Thrombocytopenia, Peripheral Neuropathy

Answer 44

Linezolid

Question 45

Which drug class is associated with the following adverse effect(s): severe diarrhea and pseudomembranous colitis

Answer 45

Clindamycin

Question 46

Which drug class is associated with the following adverse effect(s): Significant bone distribution/cartilage damage, cannot take with antacids, may prolong QT

Answer 46

Fluoroquinolones