I: STDs Flashcards
____ are cell proliferation and transformation proteins in HPV, degrading p53 and inactivating pRB respectively.
E6, E7
____ are the infectious form of chlamydia.
Elementary bodies
____ are the vegtative form of chlamydia that multiplies intracellularly
Reticulate bodies
_____ are the major and minor capsid protein in HPV.
L1, L2
Chlamydia is lacking _____ in its cell wall
N-acetylmuramic acid
Gram stain of Neisseria is more effective in men or women?
Men
Lugol iodine staining turns inclusions brown to visualize ______.
Chlamydia trachomatis
Name 4 infections characteristic of chlamydia trachomatis.
Trachoma, Urogenital infection, Inclusion Conjunctivitis, Lymphogranuloma venereum
Name the three HPV vaccines available.
Gardasil, Cervarix, Gardasil-9
Name two key sequelae in PID caused by gonorrhea or chlamydia.
Infertility, Ectopic pregnancy
Neisseria exhibit positive oxidation of _____ but not ______.
glucose; maltose, sucrose
True or False: Men are more likely to be asymptomatic in Neisseria infection.
FALSE
True or False: Women are more likely to be infected following a single exposure to Neisseria gonorrhoeae
TRUE
What are culture requirements for growing Neisseria?
> 3% carbon dioxide
What infection may be observed in infants born to mothers infected with Neisseria gonorrhoeae?
Ophthalmia Neonatorum
What is the appropriate treatment for a patient testing positive for Neisseria gonorrhoeae infection?
Ceftriaxone, Azithromycin
What is the most common notifiable disease in the US?
Chlamydia trachomatis
What is the treatment for treponema pallidum
Penicillin
Which diagnosis? Gummas, cardiovascular complications, meningitis, ocular involvement, tabes dorsalis
Tertiary syphilis
Which diagnosis? Hutchinson teeth, nerve deafness, skeletal signs
Syphilis
Which diagnosis? Mucocutaneous and skin lesions, lymphadenopathy, malaise
Secondary syphilis
Which HPV gene normally suppresses E6 and E7?
E2
Which HPV types are associated with condyloma acuminatum?
HPV6, HPV1
Which HPV types are associated with verruca plantaris on the soles or toes?
HPV1, HPV2, HPV4
Which HPV types are associated with verruca vulgaris on hands and feet?
HPV2, HPV7
Which HPV types are the most strongly associated with malignant potential?
HPV16, HPV18
Which pathogen? Chronic keratoconjunctivitis with acute inflammatory changes progressing to scarring and blindness
Chlamydia trachomatis
Which pathogen? Gram negative diplococcus or kidney shaped single cocci
Neisseria
Which pathogen? Most common cause globally of infection-induced blindness
Chlamydia trachomatis
Which pathogen? Mucopurulent conjunctivitis that may cause pneumonia
Chlamydia trachomatis
Which pathogen? Non-enveloped icosahedral DNA virus causing genital warts
HPV
Which pathogen? Small round-oval cells (gram-negative) with biphasic life cycle
Chlamydia trachomatis
Which pathogen? STD caused by long, corkscrew shaped bacilli with flagella in periplasmic space
Treponema pallidum
Which phase of syphilis infection is not mediated by the organisms?
Tertiary syphilis
Which proteins are important to Neisseria gonorrhoeae for attachment?
Opa
Which stage of syphilis is the most infectious?
Primary
Which syndrome? Small ulcer on genitalia followed by lymphadenopathy, nodes may form draining sinuses
Lymphogranuloma venereum
Which virulence factors may be important in Neisseria gonorrhoeae infection?
Lipo-oligosaccharide, IgA protease
