I: STDs

Question 1

____ are cell proliferation and transformation proteins in HPV, degrading p53 and inactivating pRB respectively.

Answer 1

E6, E7

Question 2

____ are the infectious form of chlamydia.

Answer 2

Elementary bodies

Question 3

____ are the vegtative form of chlamydia that multiplies intracellularly

Answer 3

Reticulate bodies

Question 4

_____ are the major and minor capsid protein in HPV.

Answer 4

L1, L2

Question 5

Chlamydia is lacking _____ in its cell wall

Answer 5

N-acetylmuramic acid

Question 6

Gram stain of Neisseria is more effective in men or women?

Answer 6

Men

Question 7

Lugol iodine staining turns inclusions brown to visualize ______.

Answer 7

Chlamydia trachomatis

Question 8

Name 4 infections characteristic of chlamydia trachomatis.

Answer 8

Trachoma, Urogenital infection, Inclusion Conjunctivitis, Lymphogranuloma venereum

Question 9

Name the three HPV vaccines available.

Answer 9

Gardasil, Cervarix, Gardasil-9

Question 10

Name two key sequelae in PID caused by gonorrhea or chlamydia.

Answer 10

Infertility, Ectopic pregnancy

Question 11

Neisseria exhibit positive oxidation of _____ but not ______.

Answer 11

glucose; maltose, sucrose

Question 12

True or False: Men are more likely to be asymptomatic in Neisseria infection.

Answer 12

FALSE

Question 13

True or False: Women are more likely to be infected following a single exposure to Neisseria gonorrhoeae

Answer 13

TRUE

Question 14

What are culture requirements for growing Neisseria?

Answer 14

> 3% carbon dioxide

Question 15

What infection may be observed in infants born to mothers infected with Neisseria gonorrhoeae?

Answer 15

Ophthalmia Neonatorum

Question 16

What is the appropriate treatment for a patient testing positive for Neisseria gonorrhoeae infection?

Answer 16

Ceftriaxone, Azithromycin

Question 17

What is the most common notifiable disease in the US?

Answer 17

Chlamydia trachomatis

Question 18

What is the treatment for treponema pallidum

Answer 18

Penicillin

Question 19

Which diagnosis? Gummas, cardiovascular complications, meningitis, ocular involvement, tabes dorsalis

Answer 19

Tertiary syphilis

Question 20

Which diagnosis? Hutchinson teeth, nerve deafness, skeletal signs

Answer 20

Syphilis

Question 21

Which diagnosis? Mucocutaneous and skin lesions, lymphadenopathy, malaise

Answer 21

Secondary syphilis

Question 22

Which HPV gene normally suppresses E6 and E7?

Answer 22

E2

Question 23

Which HPV types are associated with condyloma acuminatum?

Answer 23

HPV6, HPV1

Question 24

Which HPV types are associated with verruca plantaris on the soles or toes?

Answer 24

HPV1, HPV2, HPV4

Question 25

Which HPV types are associated with verruca vulgaris on hands and feet?

Answer 25

HPV2, HPV7

Question 26

Which HPV types are the most strongly associated with malignant potential?

Answer 26

HPV16, HPV18

Question 27

Which pathogen? Chronic keratoconjunctivitis with acute inflammatory changes progressing to scarring and blindness

Answer 27

Chlamydia trachomatis

Question 28

Which pathogen? Gram negative diplococcus or kidney shaped single cocci

Answer 28

Neisseria

Question 29

Which pathogen? Most common cause globally of infection-induced blindness

Answer 29

Chlamydia trachomatis

Question 30

Which pathogen? Mucopurulent conjunctivitis that may cause pneumonia

Answer 30

Chlamydia trachomatis

Question 31

Which pathogen? Non-enveloped icosahedral DNA virus causing genital warts

Answer 31

HPV

Question 32

Which pathogen? Small round-oval cells (gram-negative) with biphasic life cycle

Answer 32

Chlamydia trachomatis

Question 33

Which pathogen? STD caused by long, corkscrew shaped bacilli with flagella in periplasmic space

Answer 33

Treponema pallidum

Question 34

Which phase of syphilis infection is not mediated by the organisms?

Answer 34

Tertiary syphilis

Question 35

Which proteins are important to Neisseria gonorrhoeae for attachment?

Answer 35

Opa

Question 36

Which stage of syphilis is the most infectious?

Answer 36

Primary

Question 37

Which syndrome? Small ulcer on genitalia followed by lymphadenopathy, nodes may form draining sinuses

Answer 37

Lymphogranuloma venereum

Question 38

Which virulence factors may be important in Neisseria gonorrhoeae infection?

Answer 38

Lipo-oligosaccharide, IgA protease