Hormones Flashcards
Intracellular signaling
within cell
CDKs
cAMP
inter cellular signaling
between cells
growth factors (PDGF)
neurotransmitters
hormones
types of signalling
inter cellular
intra cellular
between organisms
local signalling molecules
- Secreted into extracellular fluid
- Travel by diffusion
- Short lived
- Very local effects
- Histamine, neurotransmitters
pheromones
Longer distance
Signal other individuals
2. Molecules travel by air
3. Sensed by vomeronasal organ
hormones
transported around body by blood Produced by endocrine system Endocrine glands/cells Some neurons (secretive neurons) Delivered by blood (diffuses in) and interstitial fluid received by target cells
target cells
. Cells with receptors for that specific hormone
intracellular receptors
Bind lipid Hormones like steroids
Testosterone and thyroid hormones
Often affect promoters regulating transcription
Anterior Pituitary regulated by
Hypothalamus
Hypothalamus
monitors hormone blood levels
Neg. Feedback: Anterior Pituitary hormones
Low levels of hormones cause hypothalamus to signal Anterior Pituitary via secretory neurons
Neurons make releasing hormones (_RH) that signal the anterior pituitary to begin secreting stimulating hormones (_SH)
releasing hormones
signal the anterior pituitary to begin secreting stimulating hormones (_SH)
Stimulating hormones
also called Tropins
are hormones that travel to an organ
Thyroid function Negative Feed back example
Hypothalamus monitors blood levels of thyroid hormones (T3/T4)
Low levels of T3/T4 cause hypothalamus to make releasing hormones (TRH) that signal the anterior pituitary to begin secreting (TSH ) thyroid stimulating Hormone
TSH binds to receptors in thyroid gland causing it to produce T3 & T4
T3/T4 feed back to shut down hypothal. & pit
membrane receptors
Membrane Receptors
Bind peptide/protein hormones
Binding produces 2nd messenger mols. Like cAMP
cAMP initiates chain reaction
resulting series of chem. rxns is called a cascade
ex. glucagon