HIV: treatment and care

Question 1

What treatment should be given for rectal chlamydia?

Answer 1

doxycycline better for rectal chlamydai than azithromycin

Question 2

How are targets for anti-retrovirals created?

Answer 2

identify processes that dont happen in normal human cells but do in infected cells

Question 3

What are the targets for anti-retroviral drugs?

Answer 3

reverse transcriptase; integrase; protease; entry-fusion; CCR5 receptor; maturation

Question 4

What is highly active anti-retroviral therapy?

Answer 4

a combination of three drugs from at least 2 drug calsses to which the virus is susceptible

Question 5

What are the purposes of highly active anti-retroviral therapy?

Answer 5

reduce viral load to undetectable; restore immunocompetence; reduce morbidity and mortality; minimise toxicity

Question 6

What ar ethe side effects of HAART?

Answer 6

rash; hypersensitivity; SJS; mood; psychosis; sleep disturbance; proximal renal tubulopatheis; osteomalacia; increased MI rsk ;anaemia; transaminitis; fulminant hepatitis

Question 7

Why is adherence so important in HAART?

Answer 7

reverse transcriptase results in lots of errers which gives lots of mutations for resistance to occur which will be in your genome forever once they occur

Question 8

How do protease inhibitiors affect liver enxymes?

Answer 8

potenet liver enzyme inhibitiros

Question 9

How do NNRTIs affect liver enzymes?

Answer 9

potenet liver enyme inducers

Question 10

What is the treatment for prevention of mother to child transmission?

Answer 10

HAART furing pregnancy; CS-detected viral load; VD-undetected; 4/52 PEP for neonate; exclusive formula feeding