Histology of the Female Reproductive System Flashcards
What is the function of the ovaries?
produces gametes; produce steroids
What is found within the medulla of the ovaries?
loose connective tissue; contorted arteries, veins and lympathatics
What is the medulla of the ovaries continuous with?
hilum of the organ
What is found in the cortex of the ovaries?
scattered ovarian follicles in a highly cellular connective tissue stroma
What is the outer shell of the ovarian cortex?
dense connective tissue layer called the tunica albuginea
What is the germinal epithelium of the ovary?
single layer of cuboidal cells covering the cortex
What other name is the germinal epithelium of the ovary called?
ovarian surface epithelium
What are oogonia?
germ cells from the yolk sac that have invaded the ovaries and proliferated by mitosis
What is oogenesis?
development of oocytes from oogonia (by meiosis)
What is folliculogenesis?
growth of the folicle- oocyte and supporting cells
What is loss of oogonia and oocytes called?
atresia
What stage of meiosis occurs in the oocytes before birth?
prophase I
What significant event occurs at prophase I?
crossing over
What cells are associated with primary oocytes?
pregranulosa cells
What is the difference between the pregranulosa cells (follicle cells) associated with primordial follicles and when follicle enters growth phase?
change from squamous to cuboidal
What defines primary follicles?
cuboidal granulosa cells
What is the name for the layer of cuboidal granulosa cells in primary follicles?
zona granulosa
What begins to form between the oocyte and granulosa cells in primary follicles?
zona pellucida
What is the zona pellucida?
layer of special extraceullar matrix
What happens with the stromal cells in the primary follicles?
stromal cells are asosicating with the outside of the follicle
What happens to the granulosa cells layer in the late primary follicle?
proliferates
What do the stromal cells around the follicle form in the late primary follicle?
theca folliculi
What happens to the inner layer of the theca folliculi?
transform to form the theca interna
What is the function of the theca interna?
secrete oestrogen precursors
What layer of cells in follicle converts oestrogen precursors to oestrogen?
granulosa cells
What happens to the outer layers of the theca folliculi?
remain fibroblast-like and form theca-externa
What defines the secondary follicle?
antrum develops in the granulosa cell
What fills the antrum?
follicular fluid
What are the very largest antral follicles called?
Graafian follicles
What is cumulus oophorus?
cloud of granulosa cells which surround cells
What is the name for the granulosa cells that are released with the oocyte?
coronoa radiata
What happens to teh oocyte in the largest Graafian follicle one day before ovulation?
completes meiosis I
What is different about the completion of meiosis I in oocytes?
doesnt produce 2 cells, but 1 cell-secondary oocyte and one tiny polar body
What phase of meiosis does the secondary oocyte stop at?
metaphase II
What happens to the follicle after ovulation?
transforms into the corpus luteum
What is the function of hte corpus luteum?
theca and granulosa cells secrete oestrogens and progesterone preparing the uterus for implantation
If no implantation occurs, what does the corpus luteum become?
corpus albicans
What happens to the corpus luteum if implantation occurs?
placental hCG prevents degeneration to maintain progesterone levels
How does the ovum move down the uterine tubes?
propelled by gentle peristlasis and currents created by the ciliated epithelium
Where does fertilisation usually occur?
in the ampulla
Describe the ampulla of the uterine tube?
mucosa is folded and lined with simple columnar ciliated epithleium and secretory cells, surrounded by SM
What is the epithelium of the isthmus of the uterine tube like?
mostly secretory with few ciliated cells
What is the difference between muscle in the ampulla and isthmus?
2 layers in ampulla and 3 in isthmus
What is the endometrium composed of?
tubular secretory glands embedded in a connective tissue stroma
What is the myometrium composed of?
3 layers of SM with collagen and elastic tissue
What is the perimetrium composed of?
loose connective tissue covered by mesothelium
What are the 2 layers of hte endometrium?
stratum functionalis and stratum basalis
What is the difference between the stratum functionalis and stratum basalis?
functionalis undergoes monthly loss whereas basalis is a reserve tissue that regereates the functionalis
What causes the stroma of the uterus to proliferate?
oestrogen
What causes the stratum functionalis to degenerate?
deprived of nutrients by spasm of spiral artery before mentruation
When does the proliferative phase of the uterus end in the menstrual cycle?
1 day after ovulation
What happens to the glands of the uterus during the secretory phase?
glands become coiled with a corkscrew appearance and secrete glycogen
What is the difference bewteen the epithelium on the vaginal surface of the cervix and further in?
stratified squamous epithelium on vaginal surface to mucous secreting simple columnar epithlium
What is significant about the transition between squamous and oclumnar epithlium?
transition zone is a common site of syplasia with common beginning of cervical cancer
What is the name for the glands of the cervix?
endocervical glands
What is the secretion of the endocervical glands in the proliferative phase?
thin and watery
What is the secretion of the endocervical glands following ovulation?
thick and viscous
What is a nabothian cyst?
when outlets of endocervical glands become blocked and expand
What are the 4 layers of hte vagina?
non-keratinised squamous epithlium; lamina propria; fibromuscular; adventita
What happens to the non-keratinized stratified squamous epithium during reproductive years?
layer is thicker and cells are enlarged due to glycogen acucumulation
What are the layers of muscles in the fibromusclar layer?
inner circular and outer longitudinal smooth muscle
What lubricates the vagina?
mucous from the endocervical glands and fluid from the thin walled blood vessels of the lamina propria
What is the function of glycogen in the vagina?
commensal metabolise the glycogen to form lactic acid
Where does the mons pubis lie?
over the subcut fat pad over the pubic sympysis
What does the skin of the mons pubis contain?
highly oblique hair follicle
What types of glands are found in the labia majora?
apocrine and sebaceous glands
What is the labia minora?
thin skin folds that lack subcut fat and hair follicles but los of vasculature and sebaceous glands
How far does keratinized epithelium extend into the vagina?
to the level of the hymen
What is the clitoris formed of?
2 tubes of erectile vascular tissue (corpora cavernosa) covered by a fibrocollagenous sheath