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3rd year > Hematology Lecture > Flashcards

Hematology Lecture Flashcards

1
Q

A life sustaining fluid which circulates through the heart and blood vessels

A

Blood

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2
Q

FORMED ELEMENTS

A

Includes erythrocytes, leukocytes, platelets and plasma

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3
Q

is the fluid that remains after coagulation has occurred and clot has formed

A

serum

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4
Q

is the liquid portion of unclotted blood

A

plasma

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5
Q

Mesoblastic Stage chief site

A

yolk sac

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6
Q

Mesoblastic Stage start day

A

19th day of Fetal Development after Fertilization

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7
Q

Mesoblastic stage Predominant cell

A

PRIMITIVE ERYTHROBLAST (PE)

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8
Q

will later differentiate into Adult Erythrocytes

A

NORMOBLASTIC CELL

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9
Q

Hemoglobin present in mesoblastic stage

A

Portland, Gower 1, Gower 11

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10
Q

a form of hemoglobin existing at low levels during embryonic and fetal life, composed of two zeta chains and two gamma chains. (2 zeta, 2 gamma)

A

portland

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11
Q

is a form of hemoglobin existing only during embryonic life, and is the primary embryonic hemoglobin. It is composed of two zeta chains and two epsilon chains, and is relatively unstable, breaking down easily. (2 zeta, 2 epsilon)

A

gower 1

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12
Q

is a form of hemoglobin existing at low levels during embryonic and fetal life. It is composed of two alpha chains and two epsilon chains, and is somewhat unstable, though not as much as hemoglobin Gower 1. (2 alpha, 2 epsilon)

A

gower 2

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13
Q

is a continuous, regulated process of blood cell production

A

hematopoiesis

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14
Q

Hepatic stage chief site

A

Liver

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15
Q

hepatic stage starts

A

5th to 7th gestational weeks

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16
Q

hepatic (Hematopoiesis during this phase occurs)

A

extravascularly

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17
Q

The major site of T cell production, kidney and Spleen which produces B cells.

A

thymus

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18
Q

The first fully developed organ in the fetus

A

thymus

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19
Q

medullary stage chief site

A

Bone marrow

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20
Q

start of medullary stage

A

4th and 5th month of fetal development

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21
Q

at the end of the 6th month _______ is the end of hematopoiesis

A

bone marrow

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22
Q

1st bone to demonstrate marrow hematopoietic activity

A

clavicle

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23
Q

hemoglobin A

A

2 alpha, 2 beta

24
Q

hemoglobin B

A

2 alpha, 2 delta

25
Q

In adults, hematopoietic tissue is located in the

A

Bone marrow
Lymph nodes
Spleen
Liver
Thymus

26
Q

Thymus and is where T and B lymphocytes are derived

A

PRIMARY LYMPHOID TISSUE

27
Q

Where Lymphoid Cells respond to foreign antigens, consists of the spleen, lymph nodes and mucosa associated lymphoid tissue.

A

SECONDARY LYMPHOID CELLS

28
Q

Major function of BM is the

A

proliferation and production of blood cells

29
Q

4 Main Functions of Red Bone Marrow

A

Production of blood cells
Destruction of erythrocytes
Iron storage (from Hb breakdown)
Central organ for B lymphocyte development

30
Q

Function in phagocytosis and secretion of various cytokines that regulate hematopoiesis

A

macrophages

31
Q

Secrete various steroids that influence erythropoiesis, maintain bone integrity and regulates the volume of marrow.

A

adipocytes

32
Q

Regulate the flow of particles entering and leaving hematopoietic spaces

A

endothelial cells

33
Q

Are bone-forming cells

A

osteoblasts

34
Q

Bone resorbing cells or destroying cells

A

osteoclasts

35
Q

Supports the vascular sinuses and developing hematopoietic cells

A

reticular cells (fibroblasts)

36
Q

a basic screening test and one of
the most frequently ordered laboratory procedure.

A

CBC

37
Q

Test that measures the number of WBC in your body

A

wbc count

38
Q

important because RBCs contain Hgb which carries oxygen to your body tissue

A

RBC count

39
Q

Measurement of the concentration of Hgb in the blood

A

HGB DETERMINATION

40
Q

Can detect immature WBC and abnormalities, both of which are signs of potential issues.

A

differential count

41
Q

Volume of packed RBC that occupies a given volume of whole blood.

A

hematocrit

42
Q

Use to assess the erythropoietic activity of the bone marrow

A

reticulocyte count

43
Q

Rate at which red blood cells sediment in a period of one hour.

A

ERYTHROCYTE SEDIMENTATION RATE (ESR)

44
Q

activities done in prior to the examination of the specimen or sample that is intended to establish system conducive to accuracy testing

A

preventive

45
Q

activities done during testing to determine whether the test systems are performing correctly

A

assessment

46
Q

done when error is detected to correct the system.

A

corrective

47
Q

is the closeness to the estimated value to the true mean.

A

Accuracy

48
Q

is the reproducibility of a result, whether accurate or inaccurate.

A

precision

49
Q

GENERAL CHARACTERISTIC OF BLAST - Very dark blue and small in amount in comparison to the size of the nucleus. No granular is present

A

Cytoplasm

50
Q

large in size as compared to the size of cytoplasm. Chromatin which is reddish purple and indicates predominance of DNA

A

nucleus

51
Q

Is a process by which erythroid precursor cells differentiates to become mature.

A

ERYTHROPOIESIS

52
Q

Erythrocytes
Shape:
protein:
lifespan:
color:
zone of pallor:

A

Anucleate, biconcave, discoid cells
Hemoglobin
120 days
salmon pink
1/3 of the center

53
Q

Hemoglobin Derivatives

A
  • Carboxyhemoglobin
  • Methemoglobin
  • Sulfhemoglobin
54
Q

Tissue located within cavities of the
cortical bone

A

bone marrow

55
Q

Secrete a semifluid extracellular matrix that serves to anchor developing hematopoietic cells in the bone cavity.

A

stromal cells

56
Q
A

3rd year (20 decks)

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