Anemia of bone marrow failure and systemic disorders

Question 1

is the reduction or cessation of blood cell production affecting one or more cell lines.

Answer 1

Bone marrow failure

Question 2

decreased numbers of circulating RBC, WBC, and platelets.

Answer 2

Pancytopenia

Question 3

Pathophysiology of Bone marrow failure

Answer 3

• Destruction of hematopoietic stem cells as a result of injury.
• premature senescence and apoptosis of hematopoietic stem cells as a result of genetic mutations.
• Ineffective hematopoiesis caused by stem cell mutations or Vitamin b12 or folate deficiency.
• Disruption of the bone marrow microenvironment that supports hematopoiesis.
• loss of hematopoietic tissue as a result of infiltration of the marrow space with abnormal cells.

Question 4

a bone marrow failure syndrome resulting from damaged or defective stem cells

Answer 4

aplastic anemia

Question 5

Who provided the first case report of aplastic anemia?

Answer 5

Ehrlich in 1888

Question 6

Who gave the name aplastic anemia?

Answer 6

Vaquez and Aubertin in 1904

Question 7

Characteristics of aplastic anemia

Answer 7

1. Pancytopenia
2. Reticulocytopenia
3. Bone marrow hypocellularity
4. Depletion of hematopoietic stem cells.

Question 8

underdevelopment or incomplete development of a tissue or organ.

Answer 8

Hypoplasia

Question 9

failure of a tissue to develop

Answer 9

aplasia

Question 10

anemia with no known cause

Answer 10

idiopathic acquired aplastic anemia

Question 11

anemia associated with an identified cause

Answer 11

secondary acquired aplastic anemia

Question 12

Bone Marrrow if

Answer 12

less than 25% bone marrow cell or less than 50% normal cellularity with less than 30% hematopoetic cells

Question 13

there are no immature myeloid cells in the peripheral blood.

Answer 13

aplastic anemia