ANEMIA OF ABNORMAL IRON METABOLISM Flashcards
ANEMIA OF ABNORMAL IRON METABOLISM
- Microcytic
- Hypochromic
necessary for the synthesis of normal
oxygen carrying hemoglobin.
Iron
storage form of iron
SERUM FERRITIN
- reflects the body tissue iron stores and thus a good indicator of iron storage status
SERUM FERRITIN
first laboratory test to become abnormal
SERUM FERRITIN
not helpful in the differentiation of IDA and Anemia of Chronic disorders because both have INCREASED values
FREE ERYTHROCYTE PROTOPORPHYRIN
measure how much the RBC can bind iron
TOTAL IRON BINDING CAPACITY (TIBC)
Transportation or iron throughout the body.
TRANSFERRIN SATURATION
Computed as:
Serum Iron/TIBC x 100
it is the last stage of iron deficiency
SERUM IRON
Men -
Post menopausal women -
Pregnant -
10mg/day
20mg/day
30 - 75mg/day
is a persistent, compulsive desire to eat a
single food or a non-food item such as starch or something crunchy such as ice, clay or plaster.
PICA
cracks in the corners of the mouth
Angular stomatitis
soreness of the tongue
Glossitis
flattening and spooning of the nails
Koilonychia
LABORATORY FINDINGS
- Decreased Hgb, Hct and RBC
- Decreased Indices
- Microcytic, hypochromic
- Elevated RDW
- Variable platelet count
- WBC and Reticulocyte count normal
SHOULD BE DONE WITH _______
PRUSSIAN BLUE STAIN
Hemoglobin values reach normal levels within
2 months
Are a diverse group identified by a common feature of abnormal iron kinetics that produces excess accumulation of iron, which is deposited in the mitochondria of normoblasts
SIDEROBLASTIC ANEMIAS
iron in the form of ferritin aggregates and at least 4 aggregates can be identified in approximately 50% of normoblasts
Type I
contains 6 aggregates
type II
pathologic ringed sideroblast
type III
For a diagnosis of Sideroblastic anemia, at least
15% of normoblasts must be Type III ringed sideroblasts.
ALA synthase deficiency
HEREDITARY (rare)
cause is unknown, almost always related to anemia
Primary (idiopathic)
Ex of primary
- Acute myeloid leukemia
- Myelodysplastic syndromes
- Myeloma
Drugs used in the treatment of tuberculosis
- Isooniazid
- Cycloserine
- Pyrazinamide
Occurs in children (ingestion of lead containing paint) and in adults (gasoline stations)
LEAD INTOXICATION
deposit of iron in different organs of
our body.
Hemosiderosis
ANEMIA OF ABNORMAL NUCLEAR DEVELOPMENT
- Macrocytic
- Normochromic
represents 75% of cobalamin in the plasina
Adenosylcobalamin
represents 75% of cobalamin in the liver robes, and the kidneys
Methylcobalamin
is a rare X-linked disorder of purine metabolism caused by the lack of the enzyme xanthine-guanine phosphoribosyl transferase.
LESCH-NYHAN SYNDROME
a rare hereditary autosomal recessive disorder of pyrimidine metabolism resulting in abnormal DNA synthesis, excessive urinary excretion of orotic acid, and megaloblastic anemia.
OROTIC ACIDURIA
