anotha cc Flashcards
paired, bean-shaped organs
kidneys
functional unit of each kidney
nephron
TEST FOR GLOMERULAR FILTRATION RATE Glomerular Filtration Rate (GFR)
- Clearance
a. Inulin Clearance (Reference Method)
b. Creatinine Clearance
c. Urea Clearance - Cystatin C
- β-trace protein
TEST FOR RENAL BLOOD FLOW
- Blood Urea Nitrogen (BUN)
- Creatinine
- Blood Uric Acid (BUA)
Measure of the clearance of normal molecules that are not bound to protein and are freely filtered by the glomeruli neither absorbed nor secreted by the tubules.
Glomerular Filtration Rate
best overall indicator of the level of kidney function
GFR
liters of glomerular filtrate is produced daily.
150
It is the removal of the substance from plasma into urine over a fixed time.
Clearance
It represents the volume of plasma that would contribute all the solute excreted
clearance
It is expressed in
mm/min
II. TEST FOR RENAL BLOOD FLOW
- Blood Urea Nitrogen (BUN)
- Creatinine
- Blood Uric Acid (BUA)
Plasma concentration and clearance are
inversely proportional
It is not routinely done because of the necessity for continuous IV infusion
Inulin Clearance
Based on the concept that once a marker has reached a steady state in the plasma and the volume of distribution is saturated, the rate of elimination of the marker will equal the rate of infusion (RI)
Plasma Inulin Clearance
Continuous Infusion Method
Plasma Inulin Clearance
requires an intravenous infusion and timed urine collection over many hours
Inulin Clearance
is a breakdown product of dietary meat and creatine phosphate found in skeletal muscle.
Creatinine
it is also secreted by the peritubular capillaries, causing CrCl to overestimate the GFR by approximately
10% to 20%.
specimen for crcl
Serum and urine samples are required. The serum collection must be within 24 hours of urine collection
A blood sample of ___ ml
1mL
Normal range
◦ 110 to 150mL/min in males
◦ 100 to 130mL/min in females.
is a better predictor of GFR than creatinine clearance
Urea Clearance
It has shown promise as a replacement for serum creatinine in estimation of GFR.
Cystatin C
a measure of the amount of creatinine eliminated from the blood by the kidneys, and
GFR are used to gauge renal function
Creatinine Clearance
