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Pharmacology > GI System: Antiulcers > Flashcards

GI System: Antiulcers Flashcards

1
Q

What do Anti-ulcer drugs do?

A

they counteract the processes that

lead to GI ulcer formation

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2
Q

What are What are five things that can lead to ulcer formation?

A

Hyperacidity, injury from drugs, bile reflux from duodenum to stomach, metabolic toxins, decreased PGE

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3
Q

What are antacids used for?

A

to increase the pH of the stomach which reduces the gastric irritation

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4
Q

What are three examples of nonsystemic antacids?

A

Calcium
magnesium
aluminum

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5
Q

how are non systemic antacids administered?

A

oral

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6
Q

what antacids will break up into individual elements?

A

nonsystemic antacid

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7
Q

what antacids is used mostly on large animals?

A

non-systemic antacids

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8
Q

What does non-systemic antacids do?

A

the minerals directly neutralize acid molecules in the stomach

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9
Q

What does calcium and aluminum antacids tend to cause?

A

constipation

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10
Q

what does magnesium antacids tend to cause?

A

diarrhea

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11
Q

repeated large doses of non-systemic antacids can cause what?

A

can cause increased absorption and high levels of the minerals

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12
Q

non-systemic antacids may interfere with what?

A

absorption of other drugs in the bowel

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13
Q

What are three examples of systemic antacids?

A

cimetidine
ranitidine
famotidine

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14
Q

what antacids are normally used in small animals?

A

systemic

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15
Q

what do systemic antacids do?

A

decrease gastric acid production in the stomach by blocking the histamine receptor

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16
Q

what does cimietidine do?

A

inhibits the liver enzymes resposnible for the metabolism and breakdown of cardiac drugs and anti-convulsant drugs

17
Q

the use of what drugs should be reduced when the animal is on famotidine? 2

A

cardiac drugs and anti-convulsant drugs

18
Q

what does omerprazole it do?

A

binds to an enzyme in the parietal cell to prevent secretion of H+ into the intestinal
lumen

19
Q

what is omeprazole used for? 2

A

a preventative and treatment in dogs, cats, and horses

20
Q

What does sucralfate do?

A

forms a sticky paste in the stomach that binds with the protiens found in open/active ulcers and stimulates PGE

21
Q

what antacid should sucralfate not be administered with?

A

systemic and non-systemic antacids

22
Q

how is sucralfate administered?

A

oral tablet or suspension

23
Q

what environment does sucralfate need?

A

acuduc

24
Q

What is misoprostol used for? 2

A

synthetic PGE

treat NSAID overdose

Pharmacology (28 decks)

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