GI System: Antiulcers Flashcards
What do Anti-ulcer drugs do?
they counteract the processes that
lead to GI ulcer formation
What are What are five things that can lead to ulcer formation?
Hyperacidity, injury from drugs, bile reflux from duodenum to stomach, metabolic toxins, decreased PGE
What are antacids used for?
to increase the pH of the stomach which reduces the gastric irritation
What are three examples of nonsystemic antacids?
Calcium
magnesium
aluminum
how are non systemic antacids administered?
oral
what antacids will break up into individual elements?
nonsystemic antacid
what antacids is used mostly on large animals?
non-systemic antacids
What does non-systemic antacids do?
the minerals directly neutralize acid molecules in the stomach
What does calcium and aluminum antacids tend to cause?
constipation
what does magnesium antacids tend to cause?
diarrhea
repeated large doses of non-systemic antacids can cause what?
can cause increased absorption and high levels of the minerals
non-systemic antacids may interfere with what?
absorption of other drugs in the bowel
What are three examples of systemic antacids?
cimetidine
ranitidine
famotidine
what antacids are normally used in small animals?
systemic
what do systemic antacids do?
decrease gastric acid production in the stomach by blocking the histamine receptor
what does cimietidine do?
inhibits the liver enzymes resposnible for the metabolism and breakdown of cardiac drugs and anti-convulsant drugs
the use of what drugs should be reduced when the animal is on famotidine? 2
cardiac drugs and anti-convulsant drugs
what does omerprazole it do?
binds to an enzyme in the parietal cell to prevent secretion of H+ into the intestinal
lumen
what is omeprazole used for? 2
a preventative and treatment in dogs, cats, and horses
What does sucralfate do?
forms a sticky paste in the stomach that binds with the protiens found in open/active ulcers and stimulates PGE
what antacid should sucralfate not be administered with?
systemic and non-systemic antacids
how is sucralfate administered?
oral tablet or suspension
what environment does sucralfate need?
acuduc
What is misoprostol used for? 2
synthetic PGE
treat NSAID overdose
