Analgesic/antiinflammatory Drugs

Question 0

What has analgesic and fever reducing properties but does not cause GI ulceration?

Answer 0

Tylenol

Question 1

What is acetaminophen a trade name?

Answer 1

Tylenol

Question 2

What happens when Tylenol is metabolized in the liver?

Answer 2

Produces a small portion of toxic metabolites that are quickly bound by glutathione

Question 3

What does glutathione do to the Tylenol metabolites?

Answer 3

Renders them nontoxic

Question 4

What can high doses of acetaminophen do?

Answer 4

Produce more toxic metabolites which can cause cellular destruction

Question 5

What are adverse effects of Tylenol?

Answer 5

RBC hemolysis
Liver tissue damage
Methemoglobinemia
Hienz body formation

Question 6

What is a toxic dose in a cat with acetaminophen?

Answer 6

50-60mg/jg

Question 7

What is the toxic dose of Tylenol in dogs?

Answer 7

> 150mg/kg

Question 8

What is DMSO?

Answer 8

Dim ethyl sulfoxide

Question 9

What does DMSO do?

Answer 9

Inactivated superoxide radicals that cause cellular damage during the inflammation

Question 10

Why is DMSO a gel?

Answer 10

Because it can penetrate intact skin and carry on drugs that are dissolved in it

Question 11

What other analgesic/antiinflammatory drug is available as an industrial grade solvent and a medical grade solvent?

Answer 11

DMSO

Question 12

What analgesic/antiinflammatory drugs can be used as a liquid and can be injected IV?

Answer 12

DMSO

Question 13

What is orgotein aka?

Answer 13

Superoxide dismutatase

Question 14

What is orgotein used for?

Answer 14

Used extensively to prevent damage caused by superoxide radicals during joint inflammation

Question 15

What are three reactions when using DMSO topically?

Answer 15

Erythema, edema, and itching

Question 16

What is a side effect that can happen when using DMSO IV?

Answer 16

Can cause hemolysis