Corticosteroids/glucocorticoids Flashcards

0
Q

What are two types of corticosteroids?

A

Mineralocorticoids and glucocorticoids

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1
Q

What are corticosteroids?

A

Hormones produced by the adrenal gland

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2
Q

What are minerralocorticoids?

A

Regulate mineral levels in the body

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3
Q

What do glucocorticoids do? 2

A

Have many effects in the body including antiinflammatory and

Inhibit production of phospholipase

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4
Q

How are corticosteroids regulated?

A

Feedback inhibition

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5
Q

What do glucocorticoids affect biologically?

A

CBC

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6
Q

What do glucocorticoids inhibit? 3

A

Scar tissue formation
T cell formation
Phospholipase production

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7
Q

What can glucocorticoids induce?

A

Labor

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8
Q

What can glucocorticoids suppress?

A

Body’s immune system

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9
Q

Of the biologic effects, What can glucocorticoids increase?

A

Gastric acid secretion
Breakdown of protien
Blood glucose levels

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10
Q

What can glucocorticoids decrease? 4

A

Inflammation
Mucus production in GI
Lymphocytes
Eosinophils

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11
Q

What can overuse of glucocorticoids lease to?

A

Hyperadrenocorticism

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12
Q

What are five symptoms of hyperadrenocorticism?

A
PUPD
Polyphagia 
Alopecia
Muscle atrophy (pot bellied)
Thin skin
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13
Q

What are glucocorticoids classified by?

A

Length of effect

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14
Q

What are short acting glucocorticoids?

A

Biologic effect lasting less than 12 hours

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15
Q

What are intermediate acting glucocorticoids?

A

Biologic effect lastig 12-36 hours

16
Q

What are long acting glucocorticoids?

A

Last longer that 48 hours

17
Q

What are two examples of short acting glucocorticoids?

A

Hydrocortisone and cortisone

18
Q

What are five examples of intermediate acting glucocorticoids?

A
Prednisone
Prednisolone
Triamcinolone
Methylprednisolone
Isoupredone
19
Q

What are three examples of long acting glucocorticoids?

A

Dexamethasone
Betamethasone
Flumethasone

20
Q

What is an aqueous solution?

A

The glucocorticoid is combined with a salt and dissolved in water

21
Q

What can be given in large doses intravenously with less risk of an adverse reaction and has a relatively rapid onset of activity?

A

Aqueous solutions

22
Q

What are two examples of aqueous solutions?

A

Dexamethasone sodium phosphate

Prednisolone sodium succinate

23
Q

This glucocorticoid formulation does not contain salt and is dissolved in alchohol and the glucocorticoid is the only active ingredient

A

Alchohol solutions

24
This formulation the glucocorticoid is suspended in a liquid and needs to be shaken
Suspensions
25
How long do suspensions take to absorb?
Period of days
26
What glucocorticoid should never be administer IV and be kept at room temp?
Suspension
27
What are two examples of suspensions?
Methylprednisolone acetate | Triancinone
28
What are six safe guidelines for glucocorticoids
Use another drug if possible Use smallest dose then reduce Avoid continuous use, alternate days Be cautious when using ones that have a long biologic or lasting effect Taper dose down when discontinuing Glucocorticoids can be infuriated by other disease processes