Antifungals Flashcards

0
Q

What are two imiddazole antifungals?

A

Ketoconazole And ittaconazole

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1
Q

What are antifungals?

A

Drugs intended for use topically for superficial fungal infections or in the body for systemic distribution for deep or systemic infections

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2
Q

How do you administer ketaconazole and itraconazole?

A

Oral

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3
Q

What was the original imiddazole that was used for systemic infections?

A

Ketoconazole

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4
Q

What are four systemic infections Ketoconazole is used for?

A

Aspergillosis, cryptococcal meningitis, blastomycosis, histoplasmosis

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5
Q

Ketoconazole is an alternative treatment for what?

A

Hyperadrenocorticism in dogs

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6
Q

What can happen to make dogs with Ketoconazole?

A

Infertility by decreasing testosterone synthesis

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7
Q

What side effect is most common and prevelent in cats?

A

GI: Anorexia, vomiting, diarrhea

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8
Q

What are five other symptoms of Ketoconazole?

A

Reversible lightening of hair coat, transient dose related suppressant on gonadal and adrenal steroid synthesis, thrombocytopenia, and hepatic toxicity

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9
Q

What is itraconazole used for?

A

Systemic mycosis

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10
Q

What are four infections itraconazole treats?

A

Aspergillosis, cryptococcal meningitis, blastomycosis, histoplasmosis

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11
Q

What are two adverse effects of itraconazole in dogs?

A

Anorexia and hepatic toxicity

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12
Q

What are five adverse effects of itraconazole in cats?

A

Anorexia, weight loss, vomiting (GI problems) hepatotoxicity, depression

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13
Q

What imiddazole does not have an appreciable effect on hormone synthesis?

A

Itraconazole

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14
Q

What imiddazole has fewer side effects in small animals?

A

Itraconazole

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15
Q

What is a polyene antifungal?

A

Amphotericin B

16
Q

How do you administer amphotericin B?

A

Iv but can be extremly toxic

17
Q

When is amphorterjcin B used?

A

When other formulas have failed or in conjunction with other medications?

18
Q

What can be a symptom of amphotericin?

A

Liver disease

19
Q

What is a superficial antifungal?

A

Griseofuvin

20
Q

What is griseofuvin used for?

A

Primarily for ringworm and other dernatophytes

21
Q

What antiparasitic works only on ringworm and dermatophytes?

A

Griseofuvin?

22
Q

What are 12 symptoms of griseovuvin?

A

Anorexia, vomitting diarrhea, anemia, neutropenia, leokopenia, thrombocytopeniA, depression, ataxia, hepatotoxici tty, dermatitis,/photosensitivity, and toxic epidermal necrolysis

23
Q

What are more susceptable to sdverse reactions?

A

Cats and kittens and pregnant animals

24
Where does griseofuvin reach high concentrations?
Skin hair and nails
25
What Are two topical antifungals?
Miconazole and nystatin
26
What is miconazole used for?
To treat detmatophytosis and ringworm
27
What is nystatin used for
Ear infections
28
How is nystatin prescribed?
Topical and oral
29
What antifungals is usually combined with other drug agents for application?
Nystatin