Antifungals Flashcards
What are two imiddazole antifungals?
Ketoconazole And ittaconazole
What are antifungals?
Drugs intended for use topically for superficial fungal infections or in the body for systemic distribution for deep or systemic infections
How do you administer ketaconazole and itraconazole?
Oral
What was the original imiddazole that was used for systemic infections?
Ketoconazole
What are four systemic infections Ketoconazole is used for?
Aspergillosis, cryptococcal meningitis, blastomycosis, histoplasmosis
Ketoconazole is an alternative treatment for what?
Hyperadrenocorticism in dogs
What can happen to make dogs with Ketoconazole?
Infertility by decreasing testosterone synthesis
What side effect is most common and prevelent in cats?
GI: Anorexia, vomiting, diarrhea
What are five other symptoms of Ketoconazole?
Reversible lightening of hair coat, transient dose related suppressant on gonadal and adrenal steroid synthesis, thrombocytopenia, and hepatic toxicity
What is itraconazole used for?
Systemic mycosis
What are four infections itraconazole treats?
Aspergillosis, cryptococcal meningitis, blastomycosis, histoplasmosis
What are two adverse effects of itraconazole in dogs?
Anorexia and hepatic toxicity
What are five adverse effects of itraconazole in cats?
Anorexia, weight loss, vomiting (GI problems) hepatotoxicity, depression
What imiddazole does not have an appreciable effect on hormone synthesis?
Itraconazole
What imiddazole has fewer side effects in small animals?
Itraconazole
What is a polyene antifungal?
Amphotericin B
How do you administer amphotericin B?
Iv but can be extremly toxic
When is amphorterjcin B used?
When other formulas have failed or in conjunction with other medications?
What can be a symptom of amphotericin?
Liver disease
What is a superficial antifungal?
Griseofuvin
What is griseofuvin used for?
Primarily for ringworm and other dernatophytes
What antiparasitic works only on ringworm and dermatophytes?
Griseofuvin?
What are 12 symptoms of griseovuvin?
Anorexia, vomitting diarrhea, anemia, neutropenia, leokopenia, thrombocytopeniA, depression, ataxia, hepatotoxici tty, dermatitis,/photosensitivity, and toxic epidermal necrolysis
What are more susceptable to sdverse reactions?
Cats and kittens and pregnant animals
Where does griseofuvin reach high concentrations?
Skin hair and nails
What Are two topical antifungals?
Miconazole and nystatin
What is miconazole used for?
To treat detmatophytosis and ringworm
What is nystatin used for
Ear infections
How is nystatin prescribed?
Topical and oral
What antifungals is usually combined with other drug agents for application?
Nystatin
