Antifungals Flashcards

0
Q

What are two imiddazole antifungals?

A

Ketoconazole And ittaconazole

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1
Q

What are antifungals?

A

Drugs intended for use topically for superficial fungal infections or in the body for systemic distribution for deep or systemic infections

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2
Q

How do you administer ketaconazole and itraconazole?

A

Oral

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3
Q

What was the original imiddazole that was used for systemic infections?

A

Ketoconazole

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4
Q

What are four systemic infections Ketoconazole is used for?

A

Aspergillosis, cryptococcal meningitis, blastomycosis, histoplasmosis

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5
Q

Ketoconazole is an alternative treatment for what?

A

Hyperadrenocorticism in dogs

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6
Q

What can happen to make dogs with Ketoconazole?

A

Infertility by decreasing testosterone synthesis

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7
Q

What side effect is most common and prevelent in cats?

A

GI: Anorexia, vomiting, diarrhea

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8
Q

What are five other symptoms of Ketoconazole?

A

Reversible lightening of hair coat, transient dose related suppressant on gonadal and adrenal steroid synthesis, thrombocytopenia, and hepatic toxicity

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9
Q

What is itraconazole used for?

A

Systemic mycosis

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10
Q

What are four infections itraconazole treats?

A

Aspergillosis, cryptococcal meningitis, blastomycosis, histoplasmosis

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11
Q

What are two adverse effects of itraconazole in dogs?

A

Anorexia and hepatic toxicity

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12
Q

What are five adverse effects of itraconazole in cats?

A

Anorexia, weight loss, vomiting (GI problems) hepatotoxicity, depression

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13
Q

What imiddazole does not have an appreciable effect on hormone synthesis?

A

Itraconazole

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14
Q

What imiddazole has fewer side effects in small animals?

A

Itraconazole

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15
Q

What is a polyene antifungal?

A

Amphotericin B

16
Q

How do you administer amphotericin B?

A

Iv but can be extremly toxic

17
Q

When is amphorterjcin B used?

A

When other formulas have failed or in conjunction with other medications?

18
Q

What can be a symptom of amphotericin?

A

Liver disease

19
Q

What is a superficial antifungal?

A

Griseofuvin

20
Q

What is griseofuvin used for?

A

Primarily for ringworm and other dernatophytes

21
Q

What antiparasitic works only on ringworm and dermatophytes?

A

Griseofuvin?

22
Q

What are 12 symptoms of griseovuvin?

A

Anorexia, vomitting diarrhea, anemia, neutropenia, leokopenia, thrombocytopeniA, depression, ataxia, hepatotoxici tty, dermatitis,/photosensitivity, and toxic epidermal necrolysis

23
Q

What are more susceptable to sdverse reactions?

A

Cats and kittens and pregnant animals

24
Q

Where does griseofuvin reach high concentrations?

A

Skin hair and nails

25
Q

What Are two topical antifungals?

A

Miconazole and nystatin

26
Q

What is miconazole used for?

A

To treat detmatophytosis and ringworm

27
Q

What is nystatin used for

A

Ear infections

28
Q

How is nystatin prescribed?

A

Topical and oral

29
Q

What antifungals is usually combined with other drug agents for application?

A

Nystatin