Exm 3 (ch 12) Flashcards
What is in the central nervous system?
Brain and spinal cord
What is in the peripheral nervous system? 
Cranial nerves, spinal nerves, enteric plexuses in the small intestine, and sensory receptors in the skin 
Motor output of the PNS
Autonomic Nervous System(involuntary) —>sympathetic division, parasympathetic, and enteric plexuses
Sympathetic—> “fight or flight” —> smooth, muscle, cardiac muscle, and glands
Parasympathetic —> “rest and digest”—> smooth, muscle, cardiac muscle, and glands
Enteric plexuses—> “rest and digest”—> smooth muscles, and glands of the digestive canal
Somatic Nervous System(voluntary)—> skeletal muscle
Sensory input for PNS
Somatic senses and special senses
Analyze incoming sensory information, store some aspects, and make decisions regarding appropriate behaviors
Integrative
Respond to stimuli via effectors and control of muscles/glands, maintain homeostasis in autonomic nervous system
Motor
bundle of axons that lies outside the brain and spinal cord
Nerves (in PNS)
fibers bring information to the CNS from general/somatic
and special senses
Sensory (afferent) (in PNS)
fibers conveys information from the CNS to effectors (muscles and glands)
• Autonomic vs. somatic
Motor (efferent)
Afferent
Senses
Efferent
Motor
conveys information from the CNS to skeletal muscle ONLY, voluntary
Somatic(SNS)
from the CNS to smooth muscle, cardiac muscle, and glands, involuntary
Autonomic(ANS)
“fight or flight” response
Sympathetic
“rest and digest” response
Parasympathetic
network of neurons controlling digestion, can function
independently but still interacts with other branches of the ANS
Enteric plexuses
What is the functional cell of nervous tissue?
Neurons
Neural impulse through neurons are called
Action potentials
receives electrical signals
Dendrites
contains nucleus and organelles
Cell body
clusters of rough ER and free
ribosomes
Nissl bodies
where the axon joins the cell body in a cone-shaped elevation
Axon hillock
propagates nerve impulses towards another neuron
Axon
unipolar/pseudounipolar are sensory or motor?
SENSORY
What cells are found in the cerebellum in dendritic branching
Purkinje cells
What cells are found in the
cerebral cortex in dendritic branching
Pyramidal cells
usually unipolar
o Conveys information to the CNS
Sensory/Afferent neurons
usually multipolar
o Conveys action potential from the CNS
Motor/Efferent neurons
usually multipolar
o Process sensory information and elicit motor response
Interneurons/Association neurons
Support the CNS
Neuroglia
tumors from glia that are super malignant and grow rapidly
Gliomas
Neuroglia: astrocytes, oligodendrocytes, microglia, ependymal cells PNS or CNS?
CNS
Neuroglia: Schwann cells and satellite cells
CNS or PNS?
PNS
many extensions like a star, uses
extensions to wrap around, bind, and provide structural support to the CNS
Astrocytes
line the CNS fluid filled cavities (ventricles of the brain and central canal of the spinal cord) and are the epithelial cells of the CNS, produce cerebrospinal fluid (CSF) from the choroid plexus
Ependymal cells
produce myelin “white matter”
• One of these produces myelin for several different axons
Oligodendrocytes
removes cellular debris,
phagocytoses microbes and damaged tissue
Microglia
produce myelin sheath in the PNS
• A single of these cells produces myelin for only one axon
Schwann cells (neurolemmocyte)
surround cell bodies of
neurons in the PNS ganglia and
regulate the exchange of materials between neuronal cell bodies and interstitial fluid
Satellite cells
Cell bodies from most neurons are called _____ when found in clusters in the PNS – the glia found here are the satellite cells
Ganglia
The myelin sheath is produced by ______ and ______ and it surrounds the axons of most neurons
Schwann cells (PNS), oligodendrocytes (CNS)
The outer nucleated cytoplasmic layer of the Schwann cell is the
Neurolemma
Cell bodies (hint which mater)
Grey mater
Axons that have been myelinated (hint which mater)
White mater
Is grey and white mater inside or outside of the spinal cord?
Grey mater inside and white outside
Is grey and white mater inside or outside of the brain?
Grey outside white inside
What they call a cluster of neuronal cell bodies in the CNS and PNS
Nucleus, ganglion
Bundles of axons in the CNS and PNS
tracts, Nerves
allow communication over short and long distances whereas
Action potentials
allow communication
over short distances only
Graded potentials
Production of an AP or a GP depends upon
the existence of a resting membrane potential and the existence of certain ion channels
allow specific ions to move across the plasma membrane down their electrochemical gradient - a concentration difference plus and electrical difference that is established by a Na+/K+ ATPase pump that uses ATP to pump 3 Na+ ions across the membrane out of the cell and subsequently brings 2 K+ ions back into the cell. (Needs an unequal distribution of charges through Na+/K+ ATPase pump)
Ion channels
So there is generally a more ____ charge outside the cell than inside the cell – separation of charges creates a_______ with lots of potential energy
Positive. resting membrane potential
alternate between open and closed
• K+ channels are more numerous than Na + channels
Leak channels
respond to chemical stimuli (…… binds to receptor)
Ligand-gated channels. Ligand
respond to mechanical vibration or pressure stimuli. Ex: stretch receptors
Mechanically-gated channels
respond to direct changes in membrane potential
Voltage-gated channels
fewer Na+ leak channels but some still gets into the cell which would disrupt the membrane potential BUT, offset by Na+/K+ ATPase that pushes 3 Na+ out for every 2K+ in so Na+ is pumped out as fast as it leaks in. (THIS CAUSES THE UNEQUAL DISTRIBUTION BETWEEN INSIDE AND OUTSIDE THE MEMBRANE)
Na+/K+ pumps
Hyperpolarized makes it more (negative/positive?) and more polarized
Negative
Depolarizing graded potentials make the membrane less polarized and the inside (less/more?) negative
Less
the process by which
graded potentials can add together to
become larger in amplitude
Summation
An _____ is a sequence of rapidly occurring
events that decrease and eventually reverse the
membrane potential and eventually restore it to the
resting state.
Action potential
An action potential is a what kind of response
All or nothing
minimum stimulus for a response
Threshold (- 55mV)
Resting membrane potential number
-70
Action potential actually starts at what number (threshold)
-50/55
Na+ in
Depolarization stage (-55 to+30)
K+ out
Repolarization phase (+30)
K+ gates slow to
close so hyperpolarization
Hyperpolarization (-90)
Action potential stages
-Resting membrane potential: Voltage-gated Na* channels are in the resting state and voltage-gated K° channels are closed.
-Stimulus causes depolarization to threshold.
-Voltage-gated Na* channel activation gates are open.
-Voltage-gated K* channels are open; Na* channels are inactivating.
-Voltage-gated K* channels are still open; Na* channels are in the resting state.
All voltage-gated Na* and K+ channels are closed. The axon plasma membrane is at resting membrane potential: small buildup of negative charges along inside surface of membrane and an equal buildup of positive charges along outside surface of membrane.
Resting stage
When membrane potential of axon reaches threshold, the Na* channel activation gates open. As Na* ions move through these channels into the neuron, a buildup of positive charges forms along inside surface of membrane and the membrane becomes depolarized.
Depolarization phase
Na+ channel inactivation gates close and K* channels open. The membrane starts to become repolarized as some K* ions leave the neuron and a few negative charges begin to build up along the inside surface of the membrane.
Repolarizing phase begins
Ka+ outflow continues. As more K* ions leave the neuron, more negative charges build up along inside surface of membrane. K* outflow eventually restores resting membrane potential. Na* channel activation gates close and inactivation gates open. Return to resting state when K* gates close.
Re-polarizing phase continues 
the period after an action potential where the membrane cannot respond to a stimulus regardless of it’s strength
Absolute refractory period
the period of time during which a subsequent action potential can be triggered but requires a larger-than- normal stimulus
Relative refractory period
In order for communication to occur from one body part to another, action potentials must travel from where they arise at the ____. This traveling is called ____
trigger zone to the axon terminals. Propagation
Action potentials do not die, they keep their strength. And Propagation of Action Potentials is One-Way
Just notes
myelinated neuron “ leaps”
from nodes of Ranvier to
allow action potentials to
bypass large segments of
membrane
Saltatory conduction
Gap junctions connect cells and allow the transfer of
information to synchronize the activity of a group of cells
Electrical synapse
One-way transfer of information from a presynaptic neuron to a postsynaptic neuron
Chemical synapse
due to excitatory neurotransmitters
• A depolarizing postsynaptic potential
Excitatory postsynaptic potentials
due to inhibitory neurotransmitters
• A hyperpolarizing postsynaptic potential
Inhibitory postsynaptic potentials
Removal of Neurotransmitter
Diffusion, acetylcholinesterase, Re-uptake (exocytosis)
single presynaptic neuron uses
several graded potentials to release a little neurotransmitter each time (in a simple
circuit) (@ 1time)
Temporal summation
several presynaptic neurons
release neurotransmitter (converging circuit) (several diff neurons simulation a single neuron added together)
Spatial summation
What does acetylcholine do
Muscle contraction
What does amino acids do
glutamate (excitatory), aspartate, GABA, glycine(inhibitory) .(in brain, could cause disorders)
What does Biogenic amines/catecholamines do
epinephrine, norepinephrine,
dopamine, serotonin. (Excitatory, makes you feel good)
What does nitric oxide and other purines do
Blood vessels
What does carbon monoxide do
Excitatory
neurotransmitters linked together
by peptide bonds
Neuropeptides
a presynaptic neuron stimulates a post-synaptic neuron. One to one ratio
Simple series
one presynaptic neuron influences several post-synaptic neurons. Simple to complex
Diverging
a post-synaptic neuron receives nerve impulses from several
different sources. Opposite of diverging
Converging
the incoming impulse stimulates the first neuron which
stimulates the second, which stimulates the third
Reverberating
a single presynaptic cell stimulates a group of
neurons that comes together and stimulates a common postsynaptic cell
Parallel after-discharge
the capability to change based on experience. Ex: the brain is very neroplastic
Plasticity
the capability to replicate or repair.
Regenerate