EXERCISE 11 Flashcards
Antagonistic interaction wherein one organism is inhibited or is killed by the production of compounds with antimicrobial effect by another.
antibiosis
When an organism adversely affects the environment of another organism, it is said to be _______
what do you call the effect or relationship of which?
antagonistic
antagonism
if antagonism is due to antibiotics, what is it called?
antibiosis
WHAT are low molecular weight chemical compounds naturally produced by some microorganisms which
can kill or inhibit growth of susceptible microbial species.
antibiotics
What life phase are ANTIBIOTICS produced in?
late logarithmic phases
4 classifications of antibiotics based on MODE OF ACTION
- inhibition of cell wall synthesis
- damage to cell membrane
- inhibition of nucleic acid and protein synthesis
- inhibition of enzymes
3 types antibiotics under INHIBITION OF CELL WALL SYNTHESIS
- Penicillin
- Ampicillin
- Bacitracin
TYPES OF INHIBITION OF CELL WALL SYNTHESIS
Only acts on GRAM + Bacteria
Bacitracin
TYPES OF INHIBITION OF CELL WALL SYNTHESIS
acts on both GRAM + and GRAM - bacteria
Ampicillin
TYPES OF INHIBITION OF CELL WALL SYNTHESIS
commonly affects GRAM + bacteria but may also act on GRAM - at greater concentrations
Penicillin
TYPES OF INHIBITION OF CELL WALL SYNTHESIS
binding and inactivating proteins present in cell wall
Penicillin
TYPES OF INHIBITION OF CELL WALL SYNTHESIS
inhibits incorporation of amino acids and nucleotides into the cell wall
Bacitracin
UNDER DAMAGE TO CYTOPLASMIC MEMBRANE
acts like cationic detergents that bind to negatively charged lipopolysaccharides of gram - bacteria
polymyxin
TYPE OF INHIBITION OF NUCLEIC ACID AND PROTEIN SYNTHESIS
BINDS TO 30S ribosomal unit
streptomycin
TYPE OF INHIBITION OF NUCLEIC ACID AND PROTEIN SYNTHESIS
competes for the A site in bacterial ribosome that prevents production of proteins
aureomycin
