Epithelial Tissue Flashcards
where can epithelia be found
body surfaces, lines body cavities and forms glands
what do epithelial cells produce
keratin intermediate filaments
what are keratin intermediate filaments useful for
tumor ID
where is the epithelia derived from
ecotoderm, endoderm or mesoderm
what parts of the epithelia are derived from the ectoderm
-epidermis (hair nails, glands, mammary glands; oral and anal mucosa
- cornea and lens of eye
-enamel organ and enamel of teeth
-anterior pituitary
-inner ear
what parts of the epithelia are derived from the neuroectoderm
-neural tube (CNS)
- pineal body, posterior pituitary, sensory epithelium of eye, ear and nose
- neural crest (PNS)
- ganglia, nerves, glial cells, adrenal medulla, melanocytes, neuroendocrine cells
what part os epithelia arise from the mesoderm
epithelium of kidneys and gonads
- mesothelium (lining pleura, peritoneal and pericardial cavities)
- endothelium (blood and lymph vessels)
-adrenal cortex
what part of epithelia is derived from endoderm
- respiratory epithelium
-alimentary epithelium (except oral and anal cavity) - liver, pancreas, gallbladder, thyroid, parathyroid, and thymus
- epithelial lining of tympanic cavity and eustacian tubes
- transitional epithelium of bladder
what are the functions of the epithelium
-barrier (skin)
- SPM
- Secretion
- absorption
- transport
-sensation
is epithhelia penetrated by blood vessels
never
what supports epithelia
basement membrane
what does the basement membrane do
separates epithelium from underlying connective tissue and blood vessels
what do epithelial cells rely on to survive
diffusion of O2 and nutrients from underlying tissue
what makes up the mucous membrane
epithelium that lines cavities that connect with outside world such as alimentary, respiratory, or urogenital tracts)
what makes up the muscularis mucosae
surface epithelium of ectoderm, basement membrane, supporting connective tissue (lamina propria), and layers of smooth muscle
what are the 3 layers of the basement membrane
lamina densa, lamina lucida, and lamina reticularis
describe the lamina lucida
most superficial, in contact with basal cell membrane
describe the lamina reticularis
most deep, merges with surrounding tissue
describe the lamina densa
anchored to underlying connective tissue by microfibrils of type 4 collagen
what are cell junctions
intercellular epithelial attachment sites
what are the types of cell junctions
occluding, adhering, communication
what is another word for occluding junctions
tight junctions
where are occluding junctions located
immediately beneath luminal surfaces of simple columnar epithelia
what are zona occludens
portions of opposing cell membranes that fuse together forming continuous cicumferential band around cells in occluding junctions
what do occluding junctions do
prevent leakage between cells by sealing intracellular spaces
where is the fascia occludens
between endothelial cells in wall of blood vessels
whats another term for adhering junctions
anchoring junctions
what do adhering junctions do
bind cells together, act as anchoring points for cell cytoskeleton
what is the zonular adherens
a continuous band characterized by transmembrane glycoproteins called cadherins
do cell membranes fuse in adhering junctions
no
what are macula adherens
small, circular patches; most common type of cell junctions
where are adhering junctions located
on the lateral surface of the cell
what attachment proteins are found in adhering junctions
desmoplakins, desmogleins, and tonofilaments
where are hemidesmosomes found
on basal surface of cell only, anchoring it to basement membrane via integrins
what type of cell junction are hemidesmosomes
adhering junctions
what type of cell junction is associated with high mechanical abrasion
hemidesmosomes
what is a junctional complex
hybrid of adhering junctions and occluding junctions
what are the zones in a junctional complex
zonula occludens, zonula adherens, macula adherens
what is another term for junctional complex
terminal bar
what is another word for zonula occludens
tight junction
what is another word for zonula adherens
adherent junction
what is another word for macula adherens
desmosomes
what is another word for communicating junctions
gap junctions
where are gap junctions located
focal or regional adherent zones located on lateral border of cell
describe gap junctions
roughly circular, intercellular contact areas containing hundreds of individual channels called connexons
what are connexons made of
a ring of 6 integral proteins