Epidemiology Flashcards

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1
Q

epidemiology definition

A

study of disease in populations

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2
Q

what was the first modern epidemiology study

A

1854 Cholera Outbreak

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3
Q

what led to this outbreak

A

poor sanitation/no sewer system

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4
Q

humors definition

A

the idea that there are four fluids in the body which must be in balance

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5
Q

what are the four humors

A

yellow bile
black bile
phlegm
blood

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6
Q

miasma definition

A

people get sick because of unclean environment and foul air

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7
Q

Germ Theory defintion

A

disease is caused by pathogen

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8
Q

who worked on the 1854 Cholera Outbreak

A

John Snow

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9
Q

who was John Snow

A

surgeon-apothecary who had experience with previous cholera outbreaks and suspected the water supply; published a call to arms in 1849 about cholera

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10
Q

what years did the 1854 Cholera Outbreak occur

A

1853-1855

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11
Q

incidence definition

A

number of new cases in a specific time

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12
Q

where did John Snow identify the outbreak to have started

A

the Broad Street water pump

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13
Q

who was Reverend Henry Whitehead

A

minister of local church looking for evidence against the water pump theory for the cholera outbreak

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14
Q

what did Reverend Henry Whitehead find about the pump and cholera

A

houses using the Broad Street pump were 9x more likely to have victims

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15
Q

who did Reverend Henry Whitehead identify has “patient zero”

A

an infant who had died two from before the outbreak from diarrhea; the infected feces seeped through cracks in basement foundation and contaminated water

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16
Q

why is cholera important

A

it was the first pathogen with a defined source of infection

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17
Q

common source epidemic definition

A

numerous individuals infected from same original source (usually breakdown in sanitation

18
Q

host-to-host epidemic definition

A

disease transmitted from infected to uninfected individual

19
Q

epidemic threshold definition

A

differs from pathogen to pathogen

20
Q

epidemic threshold factors

A

how easily is it spread
how contagious is it
symptoms
vaccines
circumstances

21
Q

measles

A

viral infection in children that is highly contagious
MMR vaccine

22
Q

influenza

A

RNA virus with segmented genome
have hemagglutinin and neuraminidase proteins

23
Q

types of influenza

A

A, B, and C

24
Q

hemagglutinin proteins

A

attach to cell
H1 through H16

25
Q

neuraminidase proteins

A

used for escape
N1 through N9

26
Q

antigenic drift definition

A

slow accumulation of mutations via replication

27
Q

antigenic shift definition

A

reshuffling of genetic material

28
Q

is antigenic drift or antigenic shift more dangeroys

A

antigenic shift

29
Q

case definition

A

list of common symptoms developed by doctor and patient reports

30
Q

characteristics of a case

A

time
place
personal

31
Q

time characteristic

A

when people are getting sick

32
Q

place characteristic

A

where individuals live, and where they are getting sick

33
Q

personal characteristic

A

who is getting sick (age, sex, cultural background, etc)

34
Q

case-control study

A

determine what factors link affected individuals and distinguish them from unaffected individuals

35
Q

types of emerging and re-emerging diseases

A
  1. invasion of a new host population by known pathogen
  2. appearance of completely new, previously unknown pathogen
  3. association of a well-known disease with a new pathogen
  4. increased virulence or a newed problem with a well-known pathogen
36
Q

example of the invasion of a new host population by a known pathogen

A

zika virus

37
Q

zika virus

A

first isolated in monkeys in Uganda in 1947, had outbreaks in mid 2000s and early 2010s
causes microcephaly
vector: aedes mosquito

38
Q

example of the appearance of a completely new, previously unknown pathogen

A

ebola

39
Q

ebola

A

first cases in 1976 in Congo and Sudan, causes hemorrhagic fever and has a high mortality rate (90%)
vector: bats?
new medication and vaccines since 2013-2014 outbreak

40
Q

example of an association between a well-known disease and a new pathogen

A

gastric ulcers caused by Heliobacter pylori

41
Q

examples of increased virulence or a renewed problem with a well-known pathogen

A

re-emerging diseases
multi-drug resistance