drug delivery systems Flashcards

1
Q

what are the 4 main groups of drug delivery?

A
  • oral
  • injection based
  • transdermal
  • carrier based
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2
Q

carrier based drugs

A

drugs are attached to substrates eg. liposomes or nanoparticles

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3
Q

forms in which drugs are given to patients

A
tablets or capsules
solutions or suspensions
ointments or creams
inhalation
injections
suppositories
pessaries
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4
Q

types of tablets and capsules

A

regular, modified release, prodrugs, enteric coated

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5
Q

what determines the drug delivery system used?

A
  • the dose of drug to be given
  • the frequency of administration
  • the timing of administration
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6
Q

what are the factors that affect a dosage regime?

A
  • find the recommended dose in the British National Formulary
  • Is there impaired renal function
  • Is there impaired hepatic function
  • Consider age and weight
  • Consider disease to be treated
  • Consider drug toxicity
  • Give a starting dose and increase dose to achieve the desired effect
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7
Q

which groups of patients are given solutions and suspensions?

A

young
elderly
patients with difficulty swallowing

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8
Q

what are the advantages of tablets and capsules?

A
  • convenient to use
  • dose is very accurate
  • reproducibilty
  • drug stability
  • ease of mass production
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9
Q

what are enteric coated tablets?

A

tablets whose disintegration is delayed until the tablet is in the small intestine

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10
Q

why are tablets enteric coated?

A
  • to protect the drug from the stomach

- to protect the stomach from the drug

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11
Q

what are the advantages of prolonged or delayed release formulations?

A
  • most disorders require prolonged therapy
  • maintains drug levels within a therapeutic range
  • reduces the need for frequent dosing
  • compliance is improved
  • improved nursing and doctor compliance
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12
Q

what are the advantages of prodrugs?

A
  • the duration of action is prolonged

- degradation is avoided in the gut

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13
Q

what is the main advantage of buccal and sublingual administration?

A

avoids first pass metabolism so is ideal for that are rapidly metabolised by the liver before they reach the systemic circulation

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14
Q

advantages of the rectal route?

A
  • bypasses first pass metabolism

- can be used for patients who are unable to swallow

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15
Q

when are drugs given intravenously?

A

rapid onset of action is needed
careful control of plasma levels is required
a drug has a short half-life

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16
Q

why may a intramuscular injection be given over IV?

A

it has a more sustained duration of action, can be months.

17
Q

vaginal routes of administration

A

pessaries

creams

18
Q

medications administered by subcutaneous injection

A

insulin
heparin
narcotic analgesics

19
Q

dermojet

A

sub-cutaneous needleless injection used for mass innoculation

20
Q

pellet implantation

A

drug is implanted under the skin as a solid pellet

21
Q

percutaneous administration methods

A

creams, ointments, skin patches

22
Q

advantages of skin patches

A

controlled, sustained blood levels of drug

23
Q

examples of drugs administered by skin patch

A

nicotine
opiates
HRT (hormone replacement therapy)
contraception

24
Q

advantages of using administration by inhalation

A
  • Drug delivered directly to site of action
  • Rapid effect
  • Small doses used
  • Little systemic absorption
  • Reduced adverse effects
25
Q

carriers used in carrier based delivery

A
  • monoclonal antibodies
  • liposomes
  • nano particles
  • genetic transfer
26
Q

monoclonal antibodies as carriers

A

bind to antigen and release drug directly to area they need to act on