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Principles of disease (Ross Lilley) > antiviral drugs > Flashcards

antiviral drugs Flashcards

1
Q

what are the anti herpes drugs ?

A 
aciclovir
famciclovir
foscarnet
valaciclovir
valganiclovir
ganiclovir
cidofovir
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2
Q

which of the anti herpes drugs are nucleoside analogues that interfere with nucleic acid synthesis?

A 
aciclovir
famciclovir
valaciclovir
ganiclovir
valganiclovir
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3
Q

what are the anti-HIV drugs?

A

3 used together:
zidovudine
nevirapine
saquinavir

and also:
lamivudine

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4
Q

which drugs are used against chronic Hepatitis B and C infections?

A 
Interferon-α
ribavavin
lamivudine
adefovir
dipivoxil
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5
Q

which drugs are used against viral respiratory infections?

A

zanamavir
oseltamivir
ribavarin

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6
Q

what does aciclovir treat and how is it administered?

A

HSV and VZV (varicella zoster virus)
it is given IV for severe infections eg. VZV pneumonitis and hereps encephalitis
orally and topically for HSV

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7
Q

what are famiclovir and valaciclovir used to treat and how are they administered?

A

HSV and Shingles

orally

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8
Q

what is ganciclovir used to treat?

A

CMV- life and sight threatening infections

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9
Q

what is valganciclovir used to treat?

A

prodrug if ganciclovir so can be given orally to treat CMV

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10
Q

what is the toxicity of ganciclovir and valganciclovir?

A

toxic to bone marrow

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11
Q

what is foscarnet used to treat?

A

HSV, VZV and CMV resistant to nucleoside analogues

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12
Q

how is foscarnet administered?

A

IV

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13
Q

what is the toxicity of foscarnet?

A

highly nephrotoxic

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14
Q

what is cidofovir used to treat?

A

CMV retinitis

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15
Q

how does zidovudine affect the HIV virus?

A

it is a nucleoside analogue so interferes with nucleic acid synthesis

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16
Q

how does nevirapine affect the HIV virus?

A

non-nucleoside reverse transcriptase inhibitor

17
Q

how does saquinavir affect the HIV virus?

A

protease inhibitor

18
Q

what is Interferon-α used to treat and how is it administered?

A

selected chronic hep. B and C infections, administered subcutaneously

19
Q

what are side affects of Interferon-α?

A

serious

20
Q

what is rabavavin used to treat?

A

chronic hep. C occasionally for severe respiratory syncytial virus (RSV)

21
Q

how is ribabvavin administered?

A

orally

22
Q

what is lamivudine used to treat and how is it administered?

A

mainly HIV but also Hep. B

given orally

23
Q

what is adefovir used to treat and how is it administered?

A

Hep. B

given orally

24
Q

what do zanamavir and oseltamivir treat?

A

influenza A and B

Principles of disease (Ross Lilley) (46 decks)

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