acute inflammation 2 Flashcards
peritonitis
inflammation of the peritoneal cavity
meningitis
inflammation of the meninges
appendicitis
inflammation of the appendix
pneumonia
inflammation of the cavities in the lungs
pneumonitis
inflammation of the lung tissue
action of neutrophils
- mobile phagocytes
- possess oxidants and enzymes which it releases.
chemotaxis
movement of a cell along a concentration gradient of a chemical.
what happens to neutrophils when the release granules
they die
pus
mixture of fluid, bits of cell, organisms and endogenous proteins
fibrinogen
coagulation factor - forms fibrin and clots exudate
where mediators of acute inflammation are found
- on endothelial cell surface membrane
- released form cells
- in plasma
collective effects of mediators
- vasodilatation
- increased permeability
- neutrophil adhesion
- chemotaxis
- itch and pain
cell surface mediators, function and examples
-help neutrophils stick to endothelial cells. eg. P-selectin and ICAM-1
mediators released from cells
- histamine
- serotonin
- prostaglandins
- leukotrienes
- omega-3polyunsaturated fatty acids
- platelet activated factor
- cytokine and chemokines
- NO
- oxygen free radicals
enzyme cascades in plasma,
- blood coagulation pathways (clots fibrinogen)
- fibrinolysis (breaking down of fibrin)
- kinin system (hormonal system involved with coagulation, inflammation, pain and blood pressure)
- complement cascade (ties inflammation with immune system)
