Antifungals Flashcards
which drugs bind to ergosterol, increasing membrane permeability?
Polyenes
what are some examples of polyenes?
amphotericin B
nystatin
what is amphotericin B used to treat?
serious yeast and filamentous fungal infections IV
what is nystatin used to treat?
yeast and filamentous fungal infections topical use only
toxixcity of amphotericin B
it has extreme hepatic, renal, cardiac toxicity
drugs that inhibit ergosterol synthesis
azoles
allyamines
subclasses of azoles
limidazoles
triazoles
examples of limidazoles
Miconazoles
ketoconazoles
what does the limidazole miconazole treat and how is it administered?
internal and external infections including yeats and dermatophytes.
topically and orally
what does the limidazole ketoconazole treat and how is it administered?
topical infections
topically and orally
give examples if triazoles
fluconazole
itraconazole
voriconazole
what does the triazole fluconazole treat and how is it administered?
yeast infections (no activity against filamentous fungi)
some resistance by candida albicans.
orally and parenterally
what does the triazole itraconazole treat and how is it administered?
yeasts and filamentous fungi
given orally and IV
what does the triazole voriconazole treat and how is it administered?
aspergillus and is administered orally and IV
give and example of an allyamine
terbinafine
