Cytokines Flashcards
1
Q
C3b: fx
A
opsonization
2
Q
complement factor: anaphylaxis
A
C3a, C4a, C5a
3
Q
C5a: fx
A
- anaphylaxis
- neutrophil chemotaxis
4
Q
complement factor: neutrophil chemotaxis
A
C5a
5
Q
what activates classic complement pathway?
A
IgG, IgM
6
Q
what inh complement?
A
- decay accelerating factor (DAF, CD55)
- C1 esterase inh
7
Q
IL-1: fx
A
- fever
- endothelium –> express adhesion mole
- induce secrete chemokine –> recruit leukocytes
8
Q
IL-1: secreted by
A
macrophage
9
Q
macrophage –> produces what cytokines?
A
- IL1, 6, 8, 12
- TNFa
10
Q
IL6: fx
A
- fever
- acute phase proteins
11
Q
IL6: secreted by
A
- macrophage
- TH2
12
Q
IL8: fx
A
neutrophil chemotaxis
13
Q
IL-12: fx
A
- T cell –> TH1
- activate NK
14
Q
IL-12: secreted by
A
- macrophage
- B cell
15
Q
IL8: secreted by
A
macrophage
16
Q
TNFa: fx
A
- septic shock
- activate endothelium
- leukocyte recruit
- vasc leak
17
Q
TNFa: secrete by
A
macrophage
18
Q
All T cells produce what cytokines?
A
IL2, 3
19
Q
IL2: fx
A
stim T cell growth
20
Q
IL2: secreted by
A
T cell
21
Q
IL3: fx
A
growth & differentiation of BM stem celsl
22
Q
IL3: secreted by
A
T cells
