Cytokines

Question 1

C3b: fx

Answer 1

opsonization

Question 2

complement factor: anaphylaxis

Answer 2

C3a, C4a, C5a

Question 3

C5a: fx

Answer 3

• anaphylaxis

- neutrophil chemotaxis

Question 4

complement factor: neutrophil chemotaxis

Answer 4

C5a

Question 5

what activates classic complement pathway?

Answer 5

IgG, IgM

Question 6

what inh complement?

Answer 6

• decay accelerating factor (DAF, CD55)

- C1 esterase inh

Question 7

IL-1: fx

Answer 7

• fever
• endothelium –> express adhesion mole
• induce secrete chemokine –> recruit leukocytes

Question 8

IL-1: secreted by

Answer 8

macrophage

Question 9

macrophage –> produces what cytokines?

Answer 9

• IL1, 6, 8, 12

- TNFa

Question 10

IL6: fx

Answer 10

• fever

- acute phase proteins

Question 11

IL6: secreted by

Answer 11

• macrophage

- TH2

Question 12

IL8: fx

Answer 12

neutrophil chemotaxis

Question 13

IL-12: fx

Answer 13

• T cell –> TH1

- activate NK

Question 14

IL-12: secreted by

Answer 14

• macrophage

- B cell

Question 15

IL8: secreted by

Answer 15

macrophage

Question 16

TNFa: fx

Answer 16

• septic shock
• activate endothelium
• leukocyte recruit
• vasc leak

Question 17

TNFa: secrete by

Answer 17

macrophage

Question 18

All T cells produce what cytokines?

Answer 18

IL2, 3

Question 19

IL2: fx

Answer 19

stim T cell growth

Question 20

IL2: secreted by

Answer 20

T cell

Question 21

IL3: fx

Answer 21

growth & differentiation of BM stem celsl

Question 22

IL3: secreted by

Answer 22

T cells