biochem Flashcards
1
Q
how does a competitive inh affect Km, Vmax? non-competitive inh?
A
- competitive: increase Km, same Vmax
- noncomp: same Km, decrease Vmax
2
Q
protein glycosylation: location
A
- ER: during translation (N-linked)
- Golgi: after translation (O-linked), trim N/O
3
Q
I cell dz: pathophys
A
impaired phosphorylation of mannose on glycoproteins –> cannot route to vacuole –> undegraded mole accum in lysosome
4
Q
what stimulates PEPCK expression?
A
- cortisol: cortisol receptor
- glucagon: cAMP/CREB
5
Q
vitB12 def: who?
A
- strict vegan
- alcoholic
6
Q
vitB12 def –> leads to?
A
- bilat peripheral neuropathy
- methylmalonic aciduria
- megaloblastic anemia (folate trap hypothesis)
7
Q
von Gierke
A
glucose 6 phosphate deH
- hypoglycemia
- lactic acidosis
- hepatomegaly
- hyperlipid
- hyperuric
8
Q
Pompe
A
lysosomal a-glucosidase
- cardiomegaly
- muscle weak
9
Q
Cori
A
debranching enzyme
- mild hypoglycemia
- liver enlrg
10
Q
McArdle
A
muscle phosphorylase
- muscle cramp/weak w exertion
- myoglobinuria
