6.18.16 FRED1

Question 1

EOM: test SO

Answer 1

down & in

Question 2

EOM: test MR

Answer 2

adduct eye

Question 3

Osgood–Schalter disease: who?

Answer 3

teenagers doing repetitive vigorous activity (running, jumping)

Question 4

immune thrombocytopenia purport (ITP): pathophys

Answer 4

IgG autoAb –> platelet Ag –> usu GPIIb/IIIa

Question 5

what is: Osgood–Schalter disease

Answer 5

inflammation of the patellar ligament at the tibial tuberosity

Question 6

what is: open label trial

Answer 6

clinical trial in which researchers & participants know which tx is being administered

Question 7

ITP: lab findings

Answer 7

• low platelet
• normal PT, PTT
• increased megakaryocytes on BM bx

Question 8

EOM: test LR

Answer 8

abduct eye

Question 9

electrical alternans: indicates?

Answer 9

• cardiac tamponade

- severe pericardial effusion

Question 10

pemphigus vulgaris: pathophys

Answer 10

autoimmune destroy desmosomes bw keratinocytes

Question 11

EOM: test IR

Answer 11

down & out

Question 12

Osgood–Schalter disease: clinical presentation

Answer 12

painful bump just below the knee

Question 13

what is the most common cause of thrombocytopenia?

Answer 13

ITP

Question 14

severe pericardial effusion –> progression

Answer 14

heart can’t fill properly –> decrease preload –> hypotension –> tachycardia

fluid backup –> elevated JVP

Question 15

what is: clinical trial

Answer 15

study therapeutic benefit of a treatment

Question 16

bullous pemphigoid: pathophys

Answer 16

autoimmune destroy hemidesmosomes bw basal cells & underlying BM

Question 17

thrombotic thrombocytopenia purpura (TTP): pathophys

Answer 17

decreased ADAMTS13 –> uncleared vWF multimers –> abnormal platelet adhesion –> micro thrombi

Question 18

what is: electrical alternans

Answer 18

alternation of QRS complex amplitude or axis between beats and a possible wandering base-line

Question 19

what are the disorders w blistering dermatosis?

Answer 19

• pemphigus vulgaris
• bullous pemphigoid
• dermatitis herpetiformis
• erythema multiforme

Question 20

what is: filgrastim

Answer 20

granulocyte colony-stimulating factor (G-CSF) analog

Question 21

bullous pemphigoid: clinical presentation

Answer 21

bullae –> skin –> not rupture easily

Question 22

TTP: classic pentad

Answer 22

• thrombocytopenia
• microangiopathic hemolytic anemia
• altered mental status
• renal fail
• fever

Question 23

elder w new blistering dz: ddx

Answer 23

• pemphigus vulgaris

- bullous pemphigoid

Question 24

EOM: test IO

Answer 24

up & in

Question 25

TTP: lab findings

Answer 25

• thrombocytopenia –> increased bleeding time
• normal PT, PTT
• anemia w schistocytes
• increased megakaryocytes on BM bx

Question 26

EOM & nerves: mnemonic

Answer 26

LR6 SO4 R3

Question 27

EOM: test SR

Answer 27

up & out

Question 28

Osgood–Schalter disease: pathophys

Answer 28

chronic stress/irritation at insertion of patellar tendon on tibial tubercle

Question 29

pemphigus vulgaris: clinical presentation

Answer 29

bullae –> skin & oral mucosa –> rupture easily