Chapter 9 Spelling Words Flashcards

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1
Q

plasma

A
  • the fluid portion of blood that is essential for transporting the cellular elements around the body
  • 90% water; rest is electrolytes, proteins, fats, glucose, billirubin, and gases
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2
Q

albumin

A
  • a plasma protein
  • 60% of the plasma proteins
  • helps maintain blood volume and blood pressure
  • their abundance attracts water into vessels by osmosis
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3
Q

edema

A

the swelling of the tissues (because of fluid seeping out of the blood into the interstitial tissues)

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4
Q

globulin

A
  • a plasma protein made by the liver and helps the synthesis of antibodies
  • 36% of the plasma proteins
  • three types=alpha, beta, gamma
  • alpha and beta globulins=transport lipids and fat-soluble vitamins in the blood
  • gamma globulins=the antibodies that function in immunity
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5
Q

fibrinogen

A
  • Factor I
  • a plasma protein converted into fibrin in the presence of calcium ions
  • 4% of all plasma proteins
  • largest plasma protein
  • essential in the process of blood clotting, coagulation
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6
Q

differentiation

A
  • a cell becomes specialized in function, each having a different purpose
  • 3 classifications-erythrocytes, leukocytes, & thrombocytes
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7
Q

erythrocyte

A
  • tiny biconcave shaped disk that is thinner in the center (to allow for the bonding of oxygen) than around the edges
  • mature red blood cells (RBCs)
  • no nucleus
  • 120 day lifespan
  • hemoglobin is the main component
  • the most numerous formed element in blood
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8
Q

hemoglobin

A
  • the main component of a RBC
  • consists of heme and globin
  • carries oxygen and carbon dioxide
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9
Q

leukocytes

A
  • larger than erythrocytes but fewer in number
  • white blood cells (WBCs)
  • does have a nucleus
  • does not possess hemoglobin
  • Their are five types in two categories (neutrophils, eosinophils, basophils, monocytes, and lymphocytes)
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10
Q

granulocytes

A
  • a group of leukocytes —-neutrophils, eosinophils, and basophils
  • they have granules in their cytoplasm that absorbs dies
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11
Q

neutrophils

A
  • 60-70% of all WBCs
  • multi-lobed nuclei
  • phagocytic, they respond to infections and tissue damage by engulfing and destroying bacteria
  • do not absorb acid or base dye well, remain neutral colored
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12
Q

eosinophils

A
  • 2-4% of WBCs
  • have a nucleus with 2 lobes
  • increase in numbers in response to an allergic reaction
  • stain a rosy red
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13
Q

basophils

A
  • secrete histamine during allergic reactions
  • secrete heparin
  • have a nucleus with 2 lobes
  • 1% of all WBCs
  • stain a dark blue with base dye
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14
Q

monocytes

A
  • 3-8% of all WBCs
  • the largest WBC
  • kidney bean shaped nucleus
  • phagocytic
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15
Q

lymphocytes

A
  • 20-25% of all WBCs
  • large, spherical-shaped nucleus
  • play an important role in the immune process; some are phagocytic and others produce antibodies to destroy bacteria
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16
Q

thrombocyte

A
  • a platelet
  • small disk shaped fragment of a megakaryocyte
  • contain no hemoglobin
  • essential for normal coagulation
  • numbers average 200,000-500,000
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17
Q

antigens

A
  • also called an agglutinogen
  • a substance on a RBC that can stimulate the body to make antibodies
  • usually a protein and reacts specifically with the antibody it caused formation of
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18
Q

antibodies

A
  • produced by the body in response to bacteria, viruses, or other foreign substances
  • a substance present in the plasma that reacts in some way with the antigen that stimulated its formation
  • once established, they are programmed to recognize the antigen as “foreign to the body” and will “attack it” it they come in contact with it again
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19
Q

agglutination

A

clumping of the red blood cells as a result of interaction with specific antibodies

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20
Q

coagulation

A
  • the clotting of blood

- the process of transforming a liquid into a solid, especially of blood

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21
Q

allergen

A

a substance that can produce a hypersensitive reaction in the body

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22
Q

allergy

A

a hypersensitive reaction to normally harmless antigens, most of which are environmental

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23
Q

anaphylaxis

A

an exaggerated, life-threatening hypersensitivity reaction to a previously encountered antigen

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24
Q

anisocytosis

A

a condition of the blood where the RBCs are of variable and abnormal size
aniso=unequal cyt/o=cell -osis=condition

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25
Q

ascites

A

an abnormal intraperitoneal accumulation of fluid containing large amounts of protein and electrolytes

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26
Q

bilrubin

A

orange-yellow pigment of bile formed principally by the breakdown of hemoglobin in red blood cells after termination of their normal life span

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27
Q

corpuscle

A

any cell of the body, red or white

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28
Q

dyscrasia

A

an abnormal condition of the blood or bone marrow, such as leukemia, aplastic anemia, or prenatal Rh incompatibility

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29
Q

electrophoresis

A

the movement of a charged particle through a liquid medium in response to changes in an electric field; the particles of certain substance will migrate in a predictable direction and speed
electr/o-electrical; electricity -phoresis=transmission

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30
Q

erythremia

A

an abnormal increase in the number of RBCs

erythr/o=red -emia=blood condition

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31
Q

erythroblast

A

immature RBC

erythr/o-=red -blast=immature cell

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32
Q

erythropoiesis

A

the process of RBC production

erythr/o=red -poiesis=formation

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33
Q

erythropoietin

A

a hormone, synthesized in the kidneys and released in the blood stream in response to anoxia (lack of oxygen)
-the hormone stimulates and activates the production of the erythrocytes thereby increasing the blood’s capacity to carry oxygen

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34
Q

fibrin

A

an insoluble protein that is the substance of a blood clot

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35
Q

globin

A

a group of 4 globulin protein molecules that become bound by the iron in heme molecules to form hemoglobin

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36
Q

hematologist

A

a medical specialist in the field of hematology

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37
Q

hematology

A

the study of blood and blood-forming tissues

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38
Q

heme

A

iron; binds with and carries oxygen in the RBCs, and releasing it to tissues that give off excess carbon dioxide

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39
Q

hemolysis

A

the breakdown of RBCs and the release of hemoglobin that occurs at the end of the life span of the red cell
hem/o=blood -lysis=destruction or detachment

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40
Q

hemorrhage

A

the loss of a large amount of blood in a short period of time, internally or externally; may be arterial, venous, or capillary
hem/o=blood -rrhage=excessive flow or discharge

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41
Q

hemostasis

A

the termination of bleeding by mechanical or chemical means or by coagulation in the body
hem/o=blood -stasis=stopping or controlling

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42
Q

heparin

A

a naturally occurring anti-clotting factor in the body

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43
Q

hyperalbumininemia

A

an increased level of albumin in the blood
hyper=excessive albumin/o=protein/albumin
-emia=blood condition

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44
Q

hyperbilirubinemia

A

higher than normal levels of bile pigment, bilirubin in the blood

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45
Q

hyperlipemia

A

excessive levels of blood fats, usual caused by a lipoprotein lipase deficiency or a defect in the conversion of low-density lipoproteins to high-density lipoproteins; also called hyperlipidemia

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46
Q

hyperlipidemia

A

same as hyperlipemia

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47
Q

leukocytopenia

A

abnormal decrease in the number of WBCs to lower than 5,000 per cubic millimeter

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48
Q

megakarocyte

A

an extremely large bone marrow cell

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49
Q

myeloid

A

of or pertaining to the bone marrow or the spinal cord

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50
Q

pancytopenia

A

a decrease in the number of red blood cells, white blood cells, and platelets
pan=all cyt/o=cell -penia=deficiency

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51
Q

platelet

A

a clotting cell; a thrombocyte

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52
Q

prothrombin

A
  • Factor II
  • a plasma protein precursor of thrombin
  • synthesized in the liver if adequate vit. K is present
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53
Q

reticulocyte

A

an immature erythrocyte consisting of a meshlike pattern of threads and particles at the former site of the nucleus

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54
Q

septicemia

A

systemic infection where pathogens are present in the circulating bloodstream, they spread from an infection some where in the body

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55
Q

seroconversion

A

a change in serologic tests from negative to positive as antibodies develop in reaction to an infection or vaccine

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56
Q

serology

A

the branch of lab medicine that studies blood serum for evidence of infection by elvaluating antigen-antibody reactions

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57
Q

serum

A

clear, thin, and sticky fluid portion of the blood that remains after coagulation; contains NO blood cells, platelets, or fibrinogen

58
Q

splenomegaly

A

abnormal enlargement of the spleen

59
Q

stem cell

A

a formative cell; whose daughter cells may give rise to other cell types

60
Q

thrombin

A

an enzyme formed from prothrombin, calcium, and thromboplastin in plasma during the clotting process; it causes fibrinogen to change to fibrin which is essential in the formation of a clott

61
Q

thrombocytopenia

A

abnormal hematologic condition where the numbers of platelets is reduced

62
Q

thromboplastin

A

a complex substance that initiates the clotting process by converting prothrombin into thrombin in the presence of calcium ion

63
Q

thrombus

A

a clot

64
Q

anemia

A
  • a condition where there is a decrease in hemoglobin in the blood to levels below the normal range, resulting in a deficiency of oxygen being delivered to the cells
  • there are various types named according to the cause
  • symptoms of all types: fatigue, paleness of skin, headache, fainting, tingling sensations, numbness, loss of appetite, swelling of lower extremities, difficulty breathing
65
Q

aplastic anemia

A
  • bone marrow depression anemia
  • an inadequacy of RBCs, WBCs, and platelets
  • due to an insult to the bone marrow’s stem cells
  • can develop after an infection, injury to bone marrow, b/c of neoplastic disorder of bone marrow, chemotherapy drugs, certain antibiotics, medications, radiation or toxic chemical exposure
  • treated with blood transfusion or bone marrow transplant
66
Q

hemolytic anemia

A

-hemolytic=the rupture or destruction of RBCs
-this anemia type=extreme reduction in circulating RBCs due to their destruction; reasons for the destruction can vary
-an=without -emia=blood condition
hem/o=blood -lytic=destruction

67
Q

granulocytosis

A

abnormally elevated number of granulocytes in the circulating blood as a reaction to any variety of inflammation or infection

68
Q

eosinophilia

A

allergic conditions such as parasitic infection or asthma, there is a spiraling of eosinophilic granulocytes

69
Q

hemochromatosis

A
  • a rare iron metabolism disease with iron deposits throughout the body, usually a complication of one of the hemolytic anemias
  • usually in men over 40
  • have a enlarged liver and bronze skin
  • secondary complications: congestive heart failure or diabetes mellitus
  • treatment: blood transfusions
70
Q

hemophilia

A
  • involves different hereditary inadequacies of coagulation factors resulting in prolonged bleeding times
  • Hemophilia A: called ‘classic hemophilia’ is the result of a deficiency or absence of antihemophilic factor VIII, which results in traumatic or spontaneous bleeding in the joints, gums, or mouth; most common characteristic is hematuria
  • Hemophilia B: called ‘Christmas disease’ is the deficiency of a coagulation factor IX
  • Hemophilia A and B are only distinguished through laboratory differentiation of factor deficiencies
  • other less common forms of hemophilia are: Von Willebrand’s disease and Rosenthal’s disease
71
Q

leukemia

A
  • excessive uncontrolled increase of immature WBCs in the blood eventually leading to infection, anemia, and thrombocytopenia
  • classified as acute or chronic
  • Acute:rapid onset and swiftly progresses to thrombocytopenia, progressive anemia, infective lesions in throat and mouth, high fever, and severe infection; affects adults and elderly
  • Chronic: gradual progression
72
Q

multiple myeloma

A
  • a malignant plasma cell neoplasm that causes an increase in the number of both mature and immature plasma cells, which often entirely replace the bone marrow and destroy the skeletal structure
  • bones become so fragile that movement can result in a fracture
  • almost everyone has the Bence Jone’s protein in their urine
  • symptoms: susceptibility to infections, anemia, hypercalcemia and renal damage
  • poor survival rate
73
Q

polycythemia vera

A
  • abnormal increase in the number of RBCs, granulocytes, and thrombocytes leading to an increase in blood volume and viscosity (thickness)
  • exact cause is unknown
  • increased blood volume congests the spleen and liver with RBCs as well as stasis and thrombosis in other areas
  • clinical manifestations include light-headedness, headaches, visual disturbances, vertigo, ruddy cynosis, of the face, and eventually congestive heart failure
  • blood must be removed
74
Q

purpura

A
  • a collection of blood beneath the skin in the form of pinpoint hemorrhages appearing as red-purple skin discolorations
  • caused from a decreased number of circulation platelets (thrombocytopenia)
  • may produce a factor that will damage its own platelets
  • idiopathic thrombocytopenic purpura
75
Q

thalassemia

A
  • a hereditary form of hemolytic anemia where the alpha or beta hemoglobin chains are defective and the production of hemoglobin is deficient creating hypochromic microcytic RBCs
  • most frequently seen in Mediterranean descent people
  • blood transfusions to save life is necessary and will eventually lead to accumulation of iron in the liver, heart and pancreas which leads to failure of the organs
76
Q

direct antiglobulin test

A
  • also called Combe’s test

- used to discover the presence of antierythrocyte antibodies present in the blood of an Rh-negative woman

77
Q

erythrocyte sedimentation rate

A
  • ESR
  • a test performed on the blood to measure the rate at which red blood cells settle out in a tube of unclotted blood
  • with an inflammation, the protein content of plasma is increased, so RBCs tend to clump on top of one another, raising their weight and increasing the ESR
  • ERS increase occurs in: pneumonia, acute myocardial infarction, severe anemia, and cancer
  • ERS decrease occurs in:congestive heart failure, sickle cell anemia, polycythemia vera, and angina pectoris
78
Q

hematocrit

A

an assessment of the RBC % in total blood volume

79
Q

lipid profile

A

measures the lipids in the blood

80
Q

prothrombin time

A

PT; a blood test used to evaluate the common pathway and extrinsic system of clot formation; assess clotting proficiency of factors I, II, V, VII and X; a PT higher than 30 is at risk of hemorrhage

81
Q

red blood cell morphology

A

an examination of the RBC on a stained blood smear to identify the form and shape of the RBCs
-can see poikilocytosis and anisocytosis

82
Q

reticulocyte count

A

a measurement of the number of circulating reticulocytes in the blood specimen

83
Q

rouleaux

A

an aggregation of RBCs viewed through the microscope that may be an artifact or may occur with persons with multiple myeloma as a result of abnormal proteins

84
Q

white blood cell differential

A

a measurement of the percentage of each specific type of circulating WBCs present in 1 mm3 of peripheral blood
-measured include neutrophils, lymphocytes, monocytes, eosinophils, and basophils

85
Q

lymph

A
  • moving fluid that comes from the blood and returns to the blood via lymphatic vessels
  • once interstitial fluid enters the lymphatic vessels, it is known as lymph
86
Q

immunity

A

the state of being protected from a disease

87
Q

immunization

A

the process of creating immunity to a specific disease

88
Q

immunology

A

the study of reaction of tissues of the immune system to antigenic stimulation

89
Q

immunologist

A

the health specialist whose training and experience is concentrated in immunology

90
Q

phagocytosis

A

the process of engulfing and destroying bacteria

91
Q

tonsils

A
  • masses of lymphatic tissue in a protective ring under the mucous membrane
  • 3 groups: pharyngeal tonsils (adenoids) near nasal cavity and throat; palatine tonsils we can easily see; lingual tonsils near the tongue base
  • help protect against bacteria
  • serve as the fist line of defense from the external environment
92
Q

acquired immunity

A

immunity that is the result of the body developing the ability to defend itself against a specific agent as a result of having the disease or receiving an immunization

93
Q

adenoids

A

the pharyngeal tonsils near the opening of the nasal cavity into the pharynx

94
Q

hypersensitivity

A
  • abnormal condition characterized by an excessive reaction to a particular stimulus
  • tissue damage resulting from exaggerated immune responses
  • caused by 4 different mechanisms: IgE-mediated type I hypersensitivity response-acute systemic response; cytoxic type II hypersensitivity reaction-antibodies and antigens bond on body cells; immune complex-mediated type III sensitivity response-huge antibody, antigen and complement proteins interact to form massive complexes; delayed type IV hypersensitivity responses-involve T cells
95
Q

immunotherapy

A

a treatment of allergic responses that administers increasingly large doses of the offending allergens to gradually develop immunity

96
Q

lymphadenopathy

A

any disorder of the lymph nodes or vessels, characterized by enlargement

97
Q

lymphocyte

A

small, agranulocytic leukocytes originating from fetal stem cells and developing in the bone marrow

98
Q

macrophage

A

any phagocytic cell that helps fight infection and dispose of waste; found in the lymph nodes, liver, spleen, lungs, brain, and spinal cord

99
Q

natural immunity

A

immunity in which we are born; also called genetic immunity

100
Q

pathogens

A

disease-producing microorganisms

101
Q

susceptible

A

a state of having a lack of resistance to pathogens and other harmful agents

102
Q

T cells

A
  • cells important to the immune response
  • they mature in the thymus
  • after maturation, they enter the blood stream and circulate the body providing defense against disease
103
Q

acquired immunodeficiency syndrome

A
  • AIDS
  • conditions that destroy the body’s immune system in the final phase of a human immunodeficiency virus (HIV)
  • primarily destroys helper T cells with CD4 receptors
104
Q

cytomegalvirus

A
  • a large species-specific herpes-type virus with a wide variety of disease effects
  • serious for people with AIDS, newborns, and those treated with immunosuppressive drugs
  • results in retinal or gastrointestinal infection
105
Q

hypersplenism

A

a syndrome involving a deficiency of one or more types of blood cells and an enlarged spleen; many causes

106
Q

Kaposi’s sarcoma

A

locally destructive malignant neoplasm of the blood vessels forming lesions on the skin, visceral organs or mucous membranes; associated with AIDS; occurs due to an overgrowth of cells that narrow the vessel diameter

107
Q

lymphoma

A
  • a lymphoid tissue neoplasm typically malignant, beginning with enlarge lymph nodes and progressing to anemia, weakness, fever, and weight loss
  • Types of lymphoma: Burkitt’s lymphoma-on jaw or abdomen seen mostly in Central Africa; Hodgkin’s disease-progressive painless enlargement of malignant tumor of the nodes and spleen seen first in the cervical region in mostly males; Non-Hodgkin’s lymphoma-any type of lymphoma other than Hodgkin’s lymphoma
108
Q

mononucleosis

A

usually caused by Epstein-Barr virus (EBV), typically benign, acute infection of the B lymphocytes

109
Q

myasthenia gravis

A

autoimmune disease where antibodies block or destroy some acetylcholine receptor sites reducing neuromuscular transmissions with facial muscle weakness symptom or even paralysis
my/o=muscle -asthenia=loss of strength

110
Q

pneumocystis carinii pneumonia

A

caused by a worldwide parasite, Pneumocystis carinii for which most people have immunity to unless immune system is compromised
pneum/o=lungs; air cyst/o=sac -is=noun ending
pneumon/o=lungs; air -ia=condition

111
Q

sarcoidosis

A

systemic inflammatory disease resulting in the formation of multiple small rounded lesions in the lungs, lymph nodes, eyes, liver, and other organs seen mostly in African American females between 20-40; can cause disability
carc/o=flesh -oid=resembling -osis=condition

112
Q

enzyme-linked immunosorbent assay

A
  • ELISA

- a blood test used for screening for an antibody to the AIDS virus

113
Q

western blot

A

test that detects the presence of the antibodies to HIV and confirms the ELISA test

114
Q

lymphangiogram

A

an X-ray assessment of the lymphatic system following injection of a contrast medium into the lymph vessels in the hand or foot
lymph/o-lymph angi/o-vessel -gram-record or picture

115
Q

bilrubin

A

the pigment of bile from the break down of RBCs at the end of their life

116
Q

immune

A

protects the body; the system consists of bone marrow, thymus, lymphoid tissues & vessels, nodes, and spleen

117
Q

immunideficiency

A

the failure of the immune system

118
Q

myasthenia gravis

A

autoimmune disease, antibodies block or destroy the acetylcholine receptor sites

119
Q

pernicious anemia

A

mature RBC deficiency; consists of circulating megaloblast, poikilocytosis, and anisocytosis

120
Q

poikliocytosis

A

RBC shape variation

121
Q

polycythemia

A

condition of excessive cells in the blood

122
Q

sickle cell anemia

A

hereditary, crescent-shaped RBCs cause low oxygen; RBCs clot causing infarction and pain

123
Q

blastocyte

A

immature cell

124
Q

chromophilic

A

pertaining to the tendancy to color—-e.g. basophils and eosinophils are chromophilic

125
Q

cytogenesis

A

the formation and development of cells

126
Q

erythrocytopenia

A

RBC deficiency

127
Q

erythrocytosis

A

RBC condition

128
Q

hemogram

A

blood record

129
Q

monocytopenia

A

monocyte deficieny

130
Q

morphology

A

the study of the forms of things

131
Q

karyocyte

A

a cell with a nucleus

132
Q

isotonic

A

same osmotic pressure as those around them

133
Q

myeloblast

A

immature bone marrow or spinal cord cell

134
Q

nucleus

A

the central control center of a cell

135
Q

phagocyte

A

a cell that engulfs and/or destroys things

136
Q

prothrombin time (PT)

A

test for the clotting formation time. time it takes to convert prothrombin into thrombin

137
Q

rouleaux

A

an aggregation of RBCs viewed through the microscope that may be an artifact or may occur with persons with multiple myeloma as a result of abnormal proteins

138
Q

sideroblast

A

immature iron-rich RBC in the bone marrow

139
Q

spheroid

A

resembling a sphere

140
Q

spherocytosis

A

condition of a sphere shaped cell